2024
Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking
Bagdas D, Addy N. Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking. Nicotine & Tobacco Research 2024, ntae241. PMID: 39413033, DOI: 10.1093/ntr/ntae241.Peer-Reviewed Original ResearchNicotine use behaviorsNicotine reinforcementNicotine intakeSelf-administrationNicotine useFlavor exposureUse behaviorsIntravenous nicotine self-administrationPattern of nicotine intakeSessions of self-administrationNicotine self-administrationIncreased nicotine intakeNicotine-related behaviorsSaccharin-flavored solutionInfluence of early exposureSeeking behaviorNo significant sex differencesSignificant sex differencesImpact of early exposureSaccharin exposureEarly exposureFlavored solutionNicotine addictionSex differencesNicotine
2022
Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice
Akinola LS, Rahman Y, Ondo O, Gonzales J, Bagdas D, Jackson A, Davidson-Wert N, Damaj MI. Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice. Frontiers In Neuroscience 2022, 16: 905330. PMID: 35769694, PMCID: PMC9234577, DOI: 10.3389/fnins.2022.905330.Peer-Reviewed Original ResearchOral nicotine consumptionEffect of mentholD2J miceMenthol effectsNicotine consumptionΑ7 nAChRsDifferential effectsTwo-bottle choiceTAAR1 geneOral aversionC57BL/6J miceNicotine rewardSystemic administrationNicotine intakeDBA/2J miceB6J micePharmacological responseNicotine addictionGenotype-specific mechanismsNicotine concentrationsMiceMouse strainsBasal preferenceGenetic factorsNicotineAnimal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence
Bagdas D, Kebede N, Zepei AM, Harris L, Minanov K, Picciotto MR, Addy NA. Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence. Current Neuropharmacology 2022, 20: 2175-2201. PMID: 35611777, PMCID: PMC9886843, DOI: 10.2174/1570159x20666220524120231.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements