2020
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bagdas D, Gul Z, Meade JA, Cam B, Cinkilic N, Gurun MS. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation. Current Neuropharmacology 2020, 18: 216-228. PMID: 31631820, PMCID: PMC7327949, DOI: 10.2174/1570159x17666191021111809.Peer-Reviewed Original ResearchConceptsLiterature searchElectronic literature searchDifferent pathological situationsChlorogenic acidPharmacologic overviewNeuropathic painPain managementChronic painInflammatory insultPreventive roleAnimal modelsInflammationPotent antioxidantCertain foodsOxidative stressEthnopharmacological reportsPutative mechanismsDietary plantsAntioxidant defenseNatural phenolic compoundsPathological situationsPainMedicinal herbsOriginal articlesPhenolic compounds
2016
Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol
Gul Z, Demircan C, Bagdas D, Buyukuysal R. Protective Effects of Chlorogenic Acid and its Metabolites on Hydrogen Peroxide-Induced Alterations in Rat Brain Slices: A Comparative Study with Resveratrol. Neurochemical Research 2016, 41: 2075-2085. PMID: 27161374, DOI: 10.1007/s11064-016-1919-8.Peer-Reviewed Original ResearchConceptsOxidative stress parametersCortical slicesRat brain slicesRat cortical slicesStress parametersChlorogenic acidChloride stainingProtective effectBrain slicesOxidative stressQuinic acidResveratrolNatural phenolic compoundsMain metaboliteMalondialdehydeCaffeic acidROS levelsIncubation mediumPhenolic compoundsAlterationsIC50 valuesPresent studyStainingΜM H2O2Oxygen species