Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test
Bagdas D, AlSharari S, Roni M, Campbell V, Muldoon P, Carroll F, Damaj M. Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test. Behavioural Brain Research 2018, 360: 262-269. PMID: 30552947, PMCID: PMC6324988, DOI: 10.1016/j.bbr.2018.12.027.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsImmobility timeWT miceDecreased immobility timeDihydro-β-erythroidineAdult male miceWild-type miceEffects of β2Nicotinic acetylcholine receptorsBaseline immobilityAntidepressant effectsPresent studyJ miceKO miceSwim testMale miceWT littermatesRole of α4Bupropion administrationBupropionAcute dosesFST behaviorTransgenic miceAcetylcholine receptorsNAChR subunits