2021
(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Bagdas D, Sevdar G, Gul Z, Younis R, Cavun S, Tae HS, Ortells MO, Arias HR, Gurun MS. (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation. Neurological Research 2021, 43: 1056-1068. PMID: 34281483, DOI: 10.1080/01616412.2021.1949684.Peer-Reviewed Original ResearchConceptsPositive allosteric modulationΑ7 nAChRsNeuropathic painΑ7-selective antagonist methyllycaconitineΑ7 nicotinic acetylcholine receptorChronic constriction injuryPaw licking behaviorNeuropathic pain modelAcute systemic administrationChronic painful conditionsAntidepressant-like activityAnti-nociceptive activityDepression-like behaviorAnxiogenic-like effectsNicotinic acetylcholine receptorsAffective behaviorHuman α7 nAChRConstriction injuryMechanical allodyniaFormalin testPain modelAntagonist methyllycaconitineChronic painPainful conditionsRat α7 nAChR
2019
Molecular and behavioral mechanisms mediating paclitaxel‐induced changes in affect‐like behavior in mice
Meade J, Toma W, Alkhlaif Y, Bagdas D, Obeng S, Selley D, Damaj M. Molecular and behavioral mechanisms mediating paclitaxel‐induced changes in affect‐like behavior in mice. The FASEB Journal 2019, 33: 807.1-807.1. DOI: 10.1096/fasebj.2019.33.1_supplement.807.1.Peer-Reviewed Original ResearchKappa-opioid receptorsPaclitaxel-induced changesDepression-like behaviorInjection of vehicleNucleus accumbensSucrose preferenceRole of KORSelective KOR antagonist norbinaltorphimineDopamine D 2 receptorsKOR antagonist norbinaltorphimineTreatment-resistant depressionFemale C57BL/6J miceQuality of lifeFull-text articlesBaby boomer populationCancer survivorsAntagonist norbinaltorphimineC57BL/6J miceOpioid receptorsCancer ageKOR agonistsNeurochemical targetsTherapeutic interventionsPalatable foodProdynorphin mRNA
2017
Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse
Toma W, Kyte S, Bagdas D, Alkhlaif Y, Alsharari S, Lichtman A, Chen Z, Del Fabbro E, Bigbee J, Gewirtz D, Damaj M. Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse. Neuropharmacology 2017, 117: 305-315. PMID: 28237807, PMCID: PMC5489229, DOI: 10.1016/j.neuropharm.2017.02.020.Peer-Reviewed Original ResearchConceptsCancer chemotherapeutic drugsCancer patientsPreclinical modelsSide effectsAffective symptomsMajor dose-limiting side effectDose-limiting side effectChemotherapeutic drugsLight/dark box testNerve fiber dysfunctionPaclitaxel-treated miceProgression-free survivalSucrose preference testDepression-like behaviorOvarian cancer patientsSevere side effectsAnxiety-like behaviorPotential therapeutic interventionsEffect of paclitaxelAnhedonia-like stateDark box testCold allodyniaNeuropathic painNegative affective symptomsNociceptive effects