2021
(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
Bagdas D, Sevdar G, Gul Z, Younis R, Cavun S, Tae HS, Ortells MO, Arias HR, Gurun MS. (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation. Neurological Research 2021, 43: 1056-1068. PMID: 34281483, DOI: 10.1080/01616412.2021.1949684.Peer-Reviewed Original ResearchConceptsPositive allosteric modulationΑ7 nAChRsNeuropathic painΑ7-selective antagonist methyllycaconitineΑ7 nicotinic acetylcholine receptorChronic constriction injuryPaw licking behaviorNeuropathic pain modelAcute systemic administrationChronic painful conditionsAntidepressant-like activityAnti-nociceptive activityDepression-like behaviorAnxiogenic-like effectsNicotinic acetylcholine receptorsAffective behaviorHuman α7 nAChRConstriction injuryMechanical allodyniaFormalin testPain modelAntagonist methyllycaconitineChronic painPainful conditionsRat α7 nAChR
2020
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bagdas D, Gul Z, Meade JA, Cam B, Cinkilic N, Gurun MS. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation. Current Neuropharmacology 2020, 18: 216-228. PMID: 31631820, PMCID: PMC7327949, DOI: 10.2174/1570159x17666191021111809.Peer-Reviewed Original ResearchConceptsLiterature searchElectronic literature searchDifferent pathological situationsChlorogenic acidPharmacologic overviewNeuropathic painPain managementChronic painInflammatory insultPreventive roleAnimal modelsInflammationPotent antioxidantCertain foodsOxidative stressEthnopharmacological reportsPutative mechanismsDietary plantsAntioxidant defenseNatural phenolic compoundsPathological situationsPainMedicinal herbsOriginal articlesPhenolic compounds
2019
Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain
Neddenriep B, Bagdas D, Contreras K, Ditre J, Wolstenholme J, Miles M, Damaj M. Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain. Neuropharmacology 2019, 160: 107793. PMID: 31562845, PMCID: PMC6924270, DOI: 10.1016/j.neuropharm.2019.107793.Peer-Reviewed Original ResearchConceptsAnalgesic-like propertiesComplete Freund's adjuvantAnti-nociceptive propertiesChronic painNeuropathic painChronic constriction injury modelAlcohol useMu-opioid systemOral ethanol administrationPain-like statePeripheral neuropathic painNeuropathic pain modelKappa-selective antagonistAcute alcohol useAnalgesic-like effectsDose-dependent reversalMechanical hypersensitivityAnalgesic effectNerve injuryPain modelAcute modelOpioid systemAcute alcoholFreund's adjuvantChronic useChapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain
Bagdas D, Kyte S, Toma W, Gurun M, Damaj M. Chapter 33 Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain. 2019, 259-266. DOI: 10.1016/b978-0-12-813035-3.00033-2.Peer-Reviewed Original ResearchNicotinic acetylcholine receptorsAcetylcholine receptorsNAChR ligandsTreatment of painRecent animal studiesNarrow therapeutic windowPeripheral nervous systemPositive allosteric modulatorsAnalgesic efficacyPain managementChronic painNeuropathic conditionsImmune cellsNovel analgesicsTherapeutic windowAnimal modelsAnimal studiesHuman studiesNervous systemNicotinic agentsAllosteric modulatorsTherapeutic potentialPainPromising agentSilent agonist
2018
The antinociceptive and anti-inflammatory properties of the α7 nAChR weak partial agonist p-CF3 N,N-diethyl-N’-phenylpiperazine
Quadri M, Bagdas D, Toma W, Stokes C, Horenstein N, Damaj M, Papke R. The antinociceptive and anti-inflammatory properties of the α7 nAChR weak partial agonist p-CF3 N,N-diethyl-N’-phenylpiperazine. Journal Of Pharmacology And Experimental Therapeutics 2018, 367: jpet.118.249904. PMID: 30111636, PMCID: PMC7593094, DOI: 10.1124/jpet.118.249904.Peer-Reviewed Original ResearchConceptsAntinociceptive activitySelective antagonist methyllycaconitineAnti-inflammatory therapyAnti-inflammatory componentsAnti-inflammatory propertiesPositive allosteric modulatorsNon-neuronal cellsNicotinic acetylcholine receptorsVivo antinociceptive activityAntiedema effectInflammatory painAntagonist methyllycaconitineChronic painInflammatory diseasesHeteromeric nAChRsReceptor subtypesElectrophysiological profileNoncompetitive antagonistAcetylcholine receptorsAgonist activityPartial agonistAllosteric modulatorsSuch drugsPromising drug targetSilent agonist
2015
The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain
Bagdas D, AlSharari S, Freitas K, Tracy M, Damaj M. The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain. Biochemical Pharmacology 2015, 97: 590-600. PMID: 25931144, PMCID: PMC4600420, DOI: 10.1016/j.bcp.2015.04.013.Peer-Reviewed Original ResearchConceptsΑ5-KO miceΑ5 nAChRInflammatory painFormalin testPain modelChronic painMouse modelTumor necrosis factor-alpha levelsLong-term inflammatory painNecrosis factor-alpha levelsPaw-licking timeTonic inflammatory painChronic pain modelsDevelopment of hyperalgesiaInflammatory pain modelWild-type miceNicotinic acetylcholine receptorsAllodynic responsesMechanical allodyniaNicotine reversalCFA injectionNeuropathic painAntinociceptive effectNociceptive behaviorPain
2014
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
Papke R, Bagdas D, Kulkarni A, Gould T, AlSharari S, Thakur G, Damaj M. The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 2014, 91: 34-42. PMID: 25497451, PMCID: PMC4312719, DOI: 10.1016/j.neuropharm.2014.12.002.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsChronic painAntinociceptive activityΑ7 nicotinic acetylcholine receptorAnalgesic-like propertiesPain-induced aversionNerve injury modelAcute thermal painNon-neuronal cellsNicotinic acetylcholine receptorsImportant affective componentIon channelsNeuropathic painPain modelNociceptive behaviorInflammatory diseasesInjury modelNS6740Α7 nAChRsΑ7 receptorsThermal painPainAcetylcholine receptorsChannel activatorNeurological disorders