Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles
Malik S, Lim J, Slack FJ, Braddock DT, Bahal R. Next generation miRNA inhibition using short anti-seed PNAs encapsulated in PLGA nanoparticles. Journal Of Controlled Release 2020, 327: 406-419. PMID: 32835710, PMCID: PMC7606596, DOI: 10.1016/j.jconrel.2020.08.026.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsMiceMicroRNAsNanoparticlesPeptide Nucleic AcidsPolylactic Acid-Polyglycolic Acid CopolymerTransfectionConceptsShort PNA probesPNA probesPLGA nanoparticlesRelease profileNanoparticle formulationNanoparticlesSuperior loadingEfficient transfection efficiencyCationic domainsPotential cancer therapySystemic deliveryTarget proteinsSize distributionProbeTransfection efficiencyMiRNA-155New avenuesPNAUniform distributionProof of conceptCancer therapeuticsCancer therapyReagentsChronic toxicityMicroscopy