2017
The stochastic nature of action potential backpropagation in apical tuft dendrites
Short SM, Oikonomou KD, Zhou WL, Acker CD, Popovic MA, Zecevic D, Antic SD. The stochastic nature of action potential backpropagation in apical tuft dendrites. Journal Of Neurophysiology 2017, 118: 1394-1414. PMID: 28566465, PMCID: PMC5558024, DOI: 10.1152/jn.00800.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCalciumDendritesFemaleMalePotassiumPyramidal CellsRatsRats, Sprague-DawleySodiumStochastic ProcessesSynapsesConceptsDendritic CaPyramidal neuronsApical tuftCortical pyramidal neuronsAction potential backpropagationRat brain slicesSpontaneous synaptic inputsDifferent cortical layersVoltage-gated CaAP backpropagationAP burstsGlutamate iontophoresisSynaptic contactsSomatic APsApical trunkAP frequencyBrain slicesDendritic physiologySynaptic inputsCortical layersChannel inactivationLocal NaNeuronsSpike-timing dependent plasticityTrials
2012
Cortical Dendritic Spine Heads Are Not Electrically Isolated by the Spine Neck from Membrane Potential Signals in Parent Dendrites
Popovic MA, Gao X, Carnevale NT, Zecevic D. Cortical Dendritic Spine Heads Are Not Electrically Isolated by the Spine Neck from Membrane Potential Signals in Parent Dendrites. Cerebral Cortex 2012, 24: 385-395. PMID: 23054810, PMCID: PMC3888368, DOI: 10.1093/cercor/bhs320.Peer-Reviewed Original Research
2011
The spatio‐temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study
Popovic MA, Foust AJ, McCormick DA, Zecevic D. The spatio‐temporal characteristics of action potential initiation in layer 5 pyramidal neurons: a voltage imaging study. The Journal Of Physiology 2011, 589: 4167-4187. PMID: 21669974, PMCID: PMC3180577, DOI: 10.1113/jphysiol.2011.209015.Peer-Reviewed Original ResearchConceptsSpike trigger zoneAction potential initiationAxon initial segmentTrigger zoneLayer 5 pyramidal neuronsPotential initiationLayer 5 pyramidal cellsMature axonsPyramidal neuronsAxonal collateralsPyramidal cellsNeuronal plasticityAction potentialsImmature axonsPotential imaging techniqueAxonsImmunocytochemical dataNeuronal computationSaltatory conductionAP propagationElectrophysiological measuresInitial segmentImaging techniquesCritical roleInitiation
2010
Action Potentials Initiate in the Axon Initial Segment and Propagate through Axon Collaterals Reliably in Cerebellar Purkinje Neurons
Foust A, Popovic M, Zecevic D, McCormick DA. Action Potentials Initiate in the Axon Initial Segment and Propagate through Axon Collaterals Reliably in Cerebellar Purkinje Neurons. Journal Of Neuroscience 2010, 30: 6891-6902. PMID: 20484631, PMCID: PMC2990270, DOI: 10.1523/jneurosci.0552-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentAxon collateralsAction potentialsPurkinje neuronsComplex spikesLocal axon collateralsCerebellar Purkinje neuronsInitial segmentFast action potentialsAxon branch pointsSynaptic inputsVoltage-sensitive dyeCerebellar cortexNeuronal processingSpike initiationDischarge frequencySingle trialCollateralsOutput cellsNeuronsRapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons
Holthoff K, Zecevic D, Konnerth A. Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons. The Journal Of Physiology 2010, 588: 1085-1096. PMID: 20156851, PMCID: PMC2852997, DOI: 10.1113/jphysiol.2009.184960.Peer-Reviewed Original ResearchConceptsRapid time courseAction potentialsDendritic spinesIndividual dendritic spinesLayer 5 pyramidal neuronsTime courseTiming-dependent synaptic plasticityDendritic branchesCentral mammalian neuronsTerminal dendritic branchesVisual cortex neuronsTerminal branchesSomatic action potentialsIndividual spinesRemote dendritesPyramidal neuronsApical dendritesCortex neuronsExcitatory synapsesSupralinear integrationSynaptic inputsVoltage-sensitive dyeJuvenile miceSynaptic plasticityVisual cortex
2007
Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre‐ and post‐synaptic activity: a combined voltage‐ and calcium‐imaging study
Canepari M, Djurisic M, Zecevic D. Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre‐ and post‐synaptic activity: a combined voltage‐ and calcium‐imaging study. The Journal Of Physiology 2007, 580: 463-484. PMID: 17272348, PMCID: PMC2075540, DOI: 10.1113/jphysiol.2006.125005.Peer-Reviewed Original ResearchConceptsLong-term potentiationHippocampal CA1 pyramidal neuronsCA1 pyramidal neuronsPost-synaptic activityPyramidal neuronsRat hippocampal CA1 pyramidal neuronsActivity-dependent long-term synaptic plasticityDendritic action potentialsCalcium imaging studiesLong-term synaptic plasticityDifferent dendritic locationsDendritic signalsDendritic locationMembrane potential transientsNMDA receptorsDendritic arborsPeak amplitudeStimulation protocolSynaptic plasticityAction potentialsMembrane depolarizationDendritic regionsBaselineNeuronsInduction
2005
Imaging of Spiking and Subthreshold Activity of Mitral Cells with Voltage‐Sensitive Dyes
DJURIŠIĆ M, ZEČEVIĆ D. Imaging of Spiking and Subthreshold Activity of Mitral Cells with Voltage‐Sensitive Dyes. Annals Of The New York Academy Of Sciences 2005, 1048: 92-102. PMID: 16154924, DOI: 10.1196/annals.1342.009.Peer-Reviewed Original ResearchConceptsSpike trigger zoneMitral cellsSite of originTrigger zonePrincipal output neuronsTerminal dendritic branchesPrimary dendritesOlfactory nerve stimulationRat olfactory bulbNerve stimulationDendritic tuftsOlfactory bulbVoltage-sensitive dyeAction potentialsNeuronal processesSubthreshold activityIndividual neuronsDendritic branchesSpike initiationIntracellular dyeEPSPsOutput neuronsNeuronsDendritesCellsImaging Brain Activity With Voltage- and Calcium-Sensitive Dyes
Baker BJ, Kosmidis EK, Vucinic D, Falk CX, Cohen LB, Djurisic M, Zecevic D. Imaging Brain Activity With Voltage- and Calcium-Sensitive Dyes. Cellular And Molecular Neurobiology 2005, 25: 245-282. PMID: 16050036, DOI: 10.1007/s10571-005-3059-6.Peer-Reviewed Original ResearchConceptsVoltage-sensitive dyeCalcium-sensitive dyeLight sourceDark noiseVibrational noiseOptical recordingRandom emissionBrain activityFluorescent protein sensorOlfactory receptor neuronsNerve terminalsOlfactory bulbSpike activityNoise ratioCell bodiesReceptor neuronsPhotonsOpticsOptimal signalNeuronsIndividual cell typesKinds of noiseExternal sourcesVoltageCell types
2004
Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones
Djurisic M, Antic S, Chen WR, Zecevic D. Voltage Imaging from Dendrites of Mitral Cells: EPSP Attenuation and Spike Trigger Zones. Journal Of Neuroscience 2004, 24: 6703-6714. PMID: 15282273, PMCID: PMC6729725, DOI: 10.1523/jneurosci.0307-04.2004.Peer-Reviewed Original ResearchConceptsSpike trigger zoneMitral cellsTrigger zoneAction potentialsPrincipal output neuronsTerminal dendritic branchesPrimary dendritesOlfactory nerve stimulationRat olfactory bulbSite of originNerve stimulationDendritic tuftsSecondary dendritesEPSP attenuationOlfactory bulbSynaptic sitesNeuronal processesIndividual neuronsDendritic branchesSpike initiationIntracellular dyeEPSPsOutput neuronsNeuronsDendrites
2003
Imaging Nervous System Activity with Voltage‐Sensitive Dyes
Zecevic D, Djurisic M, Cohen LB, Antic S, Wachowiak M, Falk CX, Zochowski MR. Imaging Nervous System Activity with Voltage‐Sensitive Dyes. Current Protocols In Neuroscience 2003, 23: 6.17.1-6.17.29. PMID: 18428582, DOI: 10.1002/0471142301.ns0617s23.Peer-Reviewed Original ResearchConceptsNumber of photonsVoltage-sensitive dyeVoltage-sensitive dye measurementsLight sourceShot noiseOptical recordingOptical recording methodSynaptic inputsChoice of dyeSimultaneous measurementNervous system activityAction potential outputAplysia abdominal ganglionLarge signalNoise ratioAbdominal ganglionNervous systemPhotonsDye measurementsOpticsMotor outputSystem activitySensory stimuliMeasurementsVertebrate brain
2000
Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ
Antic S, Wuskell J, Loew L, Zecevic D. Functional profile of the giant metacerebral neuron of Helix aspersa: temporal and spatial dynamics of electrical activity in situ. The Journal Of Physiology 2000, 527: 55-69. PMID: 10944170, PMCID: PMC2270048, DOI: 10.1111/j.1469-7793.2000.00055.x.Peer-Reviewed Original ResearchConceptsTrigger zoneNeuronal processesGiant metacerebral neuronSingle neuronsMulti-site optical recordingSpike trigger zoneAction potential initiationIdentified snail neuronsMetacerebral neuronsAxonal branchesVoltage-sensitive dyeSynaptic inputsPropagation of spikesSnail neuronsAction potentialsAxonal spikesPatterns of initiationNeuronsPotential initiationSynaptic signalsIndividual neuronsElectrical activityHelix aspersaFunctional profilesInitiation
1999
Fast multisite optical measurement of membrane potential: three examples
Antic S, Cohen L, Lam Y, Wachowiak M, Zecevic D, Zochowski M. Fast multisite optical measurement of membrane potential: three examples. The FASEB Journal 1999, 13: s271-s276. PMID: 10619142, DOI: 10.1096/fasebj.13.9002.s271.Peer-Reviewed Original ResearchFast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons
Antic S, Major G, Zecevic D. Fast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons. Journal Of Neurophysiology 1999, 82: 1615-1621. PMID: 10482775, DOI: 10.1152/jn.1999.82.3.1615.Peer-Reviewed Original ResearchConceptsBasolateral dendritesApical dendritesBrain slicesVoltage-sensitive dyeNeuronal processesPyramidal neuronsMembrane potential transientsPharmacological effectsSynaptic stimulationAction potentialsInvertebrate neuronsNeuronsPatch electrodeSingle neuronsElectrical activityMembrane potential changesFast optical recordingDistal processesVertebrate neuronsOptical recordingDendritesH incubation periodStimulationApical processesRecordings
1998
Fast optical measurement of membrane potential changes at multiple sites on an individual nerve cell
Zecevic D, Antic S. Fast optical measurement of membrane potential changes at multiple sites on an individual nerve cell. Journal Of Molecular Histology 1998, 30: 197-216. PMID: 10188927, DOI: 10.1023/a:1003299420524.Peer-Reviewed Original Research
1995
Optical recording from cerebellar Purkinje cells using intracellularly injected voltage-sensitive dyes
Kogan A, Ross W, Zecevic D, Lasser-Ross N. Optical recording from cerebellar Purkinje cells using intracellularly injected voltage-sensitive dyes. Brain Research 1995, 700: 235-239. PMID: 8624715, DOI: 10.1016/0006-8993(95)00956-q.Peer-Reviewed Original ResearchOptical signals from neurons with internally applied voltage-sensitive dyes
Antic S, Zecevic D. Optical signals from neurons with internally applied voltage-sensitive dyes. Journal Of Neuroscience 1995, 15: 1392-1405. PMID: 7869106, PMCID: PMC6577832, DOI: 10.1523/jneurosci.15-02-01392.1995.Peer-Reviewed Original ResearchConceptsOptical signalVoltage-sensitive dyeSilicon photodiode arrayAxonal branchesAction potentialsIndividual neuronsOptical monitoringPresent sensitivityPhotodiode arraySite of stimulationAction potential initiationLong axonal branchesSatisfactory signalIntracellular pressure injectionSynaptic potentialsFluorescence measurementsGood signalAxonal segmentsSubthreshold potentialsExtracellular applicationCell bodiesNeuronal processesFluorescence signalElectrotonic responsesPotential initiation
1993
Optical measurement of action potential activity in invertebrate ganglia.
Wu J, Falk C, Cohen L, Tsau Y, Zecevic D. Optical measurement of action potential activity in invertebrate ganglia. The Journal Of Physiological Sciences 1993, 43 Suppl 1: s21-9. PMID: 8271496.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1989
Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex
Zecevic D, Wu J, Cohen L, London J, Hopp H, Falk C. Hundreds of neurons in the Aplysia abdominal ganglion are active during the gill-withdrawal reflex. Journal Of Neuroscience 1989, 9: 3681-3689. PMID: 2795148, PMCID: PMC6569909, DOI: 10.1523/jneurosci.09-10-03681.1989.Peer-Reviewed Original ResearchOptical Measurement of Action Potential Activity in Invertebrate Ganglia
Cohen L, Hopp H, Wu J, Xiao C, London J, Zecevic D. Optical Measurement of Action Potential Activity in Invertebrate Ganglia. Annual Review Of Physiology 1989, 51: 527-541. PMID: 2653195, DOI: 10.1146/annurev.ph.51.030189.002523.Peer-Reviewed Original ResearchConceptsAplysia abdominal ganglionGill withdrawal reflexBuccal gangliaAbdominal ganglionAction potential activitySynaptic potentialsGill withdrawalSpike activityGangliaNeuronal basisNeuronsInvertebrate gangliaBehaving animalsReflexNetwork of cellsPotential activityFeedingOptical measurementsActivity
1987
Optical recording of action potential propagation in demyelinated frog nerve
Shrager P, Chiu SY, Ritchie JM, Zecevic D, Cohen LB. Optical recording of action potential propagation in demyelinated frog nerve. Biophysical Journal 1987, 51: 351-355. PMID: 3493812, PMCID: PMC1329897, DOI: 10.1016/s0006-3495(87)83342-8.Peer-Reviewed Original Research