2022
Interspecies commensal interactions have nonlinear impacts on host immunity
Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW. Interspecies commensal interactions have nonlinear impacts on host immunity. Cell Host & Microbe 2022, 30: 988-1002.e6. PMID: 35640610, PMCID: PMC9283318, DOI: 10.1016/j.chom.2022.05.004.Peer-Reviewed Original ResearchConceptsImmunological outcomesCell activationIntestinal epithelial cell activationInflammatory bowel disease patientsBowel disease patientsDendritic cell activationMesenteric lymph nodesSystemic antibody responsesEpithelial cell activationImmunological milieuLymph nodesAntibody responseDisease patientsAkkermansia muciniphilaGnotobiotic miceHost immunityCommensal microbesHuman cohortsHuman gut bacteriaGut bacteriaMiceAllobaculumMuciniphilaDiseaseIncomplete penetrance
2021
Adaptive immunity induces mutualism between commensal eukaryotes
Ost KS, O’Meara T, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O’Connell R, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature 2021, 596: 114-118. PMID: 34262174, PMCID: PMC8904204, DOI: 10.1038/s41586-021-03722-w.Peer-Reviewed Original ResearchConceptsAdaptive immunityIntestinal immunoglobulin A (IgA) responseIntestinal IgA responsesImmunoglobulin A ResponsesIgA responsesIntestinal damageImmune responseIntestinal microbiotaRelevant vaccinesImmune systemA responsesCommensal fungiImmune selectionCandida speciesImmunityHyphal morphotypesIgAPathogenesisMiceC. albicansPathogenic Candida speciesCandida albicansAlbicansColitisResponse