2018
Revisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System
Ganesh S, Vidya K, Rashid A, Singh J, D’Souza D. Revisiting the Consequences of Adolescent Cannabinoid Exposure Through the Lens of the Endocannabinoid System. Current Addiction Reports 2018, 5: 418-427. DOI: 10.1007/s40429-018-0233-8.Peer-Reviewed Original ResearchAdolescent cannabinoid exposureCannabinoid exposureEndocannabinoid systemHuman studiesAdolescent cannabis exposurePersistent consequencesPatterns of cannabisPotential molecular mechanismsExogenous cannabinoidsCannabis exposureSynaptic potentiationAnimal modelsAdolescent exposureConflicting resultsNeurodevelopmentExposureCannabinoidsMolecular mechanismsPlausible linkRecent studiesPersistent effectsCompelling evidenceCognitive consequencesFurther researchEpigenetic mechanisms
2010
Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists
Krystal JH, Mathew SJ, D’Souza D, Garakani A, Gunduz-Bruce H, Charney DS. Potential Psychiatric Applications of Metabotropic Glutamate Receptor Agonists and Antagonists. CNS Drugs 2010, 24: 669-693. PMID: 20658799, DOI: 10.2165/11533230-000000000-00000.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPreliminary clinical trialsPositive allosteric modulatorsPsychiatric disordersClinical trialsAnimal modelsAllosteric modulatorsGroup II mGluR agonistGroup IMetabotropic glutamate receptor agonistAnxiety disordersPotential psychiatric applicationsGlutamate receptor agonistsMetabotropic glutamate receptorsTreatment of schizophreniaRole of glutamateForm of depressionMGluR agonistAntidepressant propertiesMGluR5 agonistReceptor agonistGlutamate receptorsMood disordersArea of schizophreniaPromising agentAgonists