2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2018
Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Hruska CB, Geske JR, Swanson TN, Mammel AN, Lake DS, Manduca A, Conners AL, Whaley DH, Scott CG, Carter RE, Rhodes DJ, O’Connor M, Vachon CM. Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study. Breast Cancer Research 2018, 20: 46. PMID: 29871661, PMCID: PMC5989426, DOI: 10.1186/s13058-018-0973-3.Peer-Reviewed Original Research
2016
Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study
Hruska CB, Scott CG, Conners AL, Whaley DH, Rhodes DJ, Carter RE, O’Connor M, Hunt KN, Brandt KR, Vachon CM. Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study. Breast Cancer Research 2016, 18: 42. PMID: 27113363, PMCID: PMC4845425, DOI: 10.1186/s13058-016-0704-6.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeCase-control studyBreast cancer casesRisk factorsBreast cancerCancer casesParenchymal uptakeIncident breast cancer casesBreast cancer risk factorsRetrospective case-control studyDense breastsConditional logistic regression analysisInvasive breast cancer casesPostmenopausal hormone useCancer risk factorsFunctional imaging biomarkersBreast cancer riskLogistic regression analysisBI-RADS densityPostmenopausal womenEligible womenMenopausal statusHormone useMedian ageSupplemental screening
2015
Journal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts.
Rhodes DJ, Hruska CB, Conners AL, Tortorelli CL, Maxwell RW, Jones KN, Toledano AY, O'Connor MK. Journal club: molecular breast imaging at reduced radiation dose for supplemental screening in mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 241-51. PMID: 25615744, PMCID: PMC4423604, DOI: 10.2214/ajr.14.13357.Peer-Reviewed Original ResearchConceptsCancer detection rateMolecular breast imagingDense breastsOverall cancer detection rateInvasive cancer detection rateDetection ratePositive predictive valueRadiation dose reductionAsymptomatic womenBilateral cancerDCIS detectionSupplemental screeningInvasive diseaseBiopsy rateDose reductionReduced radiation dosePredictive valueMolecular breastBreastScreening mammographyDiagnostic performanceRadiopharmaceutical activityCancerRadiation doseMammography
2012
Gamma camera breast imaging lexicon.
Conners AL, Maxwell RW, Tortorelli CL, Hruska CB, Rhodes DJ, Boughey JC, Berg WA. Gamma camera breast imaging lexicon. American Journal Of Roentgenology 2012, 199: w767-74. PMID: 23169751, DOI: 10.2214/ajr.11.8298.Peer-Reviewed Original Research
2010
Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection
2008
Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors.
Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O'Connor MK. Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors. American Journal Of Roentgenology 2008, 191: 1805-15. PMID: 19020253, PMCID: PMC3885170, DOI: 10.2214/ajr.07.3693.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsEquipment DesignEquipment Failure AnalysisFemaleGamma CamerasHumansImage EnhancementMiddle AgedMolecular Probe TechniquesRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySingle-Blind MethodTechnetium Tc 99m SestamibiConceptsMolecular breast imagingMolecular breastBI-RADS category 4Breast imagingMBq of technetiumSmall breast tumorsTelluride gamma cameraGamma cameraSubcentimeter lesionsUptake scoreAdditional cancersBlinded reviewDetection of cancerBreast tumorsLesionsSmall lesionsBreastPatientsBreast lesionsBlinded readersCancerOblique viewCategory 4Mediolateral oblique viewTumors
2007
Molecular Breast Imaging: Advantages and Limitations of a Scintimammographic Technique in Patients with Small Breast Tumors
O'Connor MK, Phillips SW, Hruska CB, Rhodes DJ, Collins DA. Molecular Breast Imaging: Advantages and Limitations of a Scintimammographic Technique in Patients with Small Breast Tumors. The Breast Journal 2007, 13: 3-11. PMID: 17214787, DOI: 10.1111/j.1524-4741.2006.00356.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCarcinoma, PapillaryFemaleHumansMammographyMiddle AgedPredictive Value of TestsRadionuclide ImagingSensitivity and SpecificityTechnetium Tc 99m SestamibiUltrasonographyConceptsMolecular breast imagingSmall breast tumorsBreast tumorsEvidence of cancerFalse-positive scansLarger patient populationMalignant breast tumorsStandard mammographic viewsMBq TcOccult tumorsPatient populationMalignant tumorsPositive scansPatientsTumorsBreast tissueSubjective discomfortBiopsySurgeryMammographic viewsGamma cameraBreast imagingBreast thicknessPreliminary studyRegular detection
2005
Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast
Rhodes DJ, O'Connor MK, Phillips SW, Smith RL, Collins DA. Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast. Mayo Clinic Proceedings 2005, 80: 24-30. DOI: 10.4065/80.1.24.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMalignant lesionsTechnetium TcBreast parenchymaEvidence of cancerTrue-negative scansFalse-positive scansSensitivity of mammographyTelluride gamma cameraMagnetic resonance imagingTrue positive casesMalignant breast lesionsGamma cameraFat necrosisFalse-positive resultsSmall cancersAdditional lesionsDetection of lesionsSmall tumorsPatientsBenign fibroadenomasLesionsResonance imagingBreast contralateralSurgery