2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2019
Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testInterventionClassification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network
Carter RE, Attia ZI, Geske JR, Conners AL, Whaley DH, Hunt KN, O’Connor M, Rhodes DJ, Hruska CB. Classification of Background Parenchymal Uptake on Molecular Breast Imaging Using a Convolutional Neural Network. JCO Clinical Cancer Informatics 2019, 3: 1-11. PMID: 30807208, PMCID: PMC6446086, DOI: 10.1200/cci.18.00133.Peer-Reviewed Original ResearchConceptsConvolutional neural networkNeural networkDeep learning modelsImage convolutionLearning modelModel performanceBackground parenchymal uptakeTesting dataComputer algorithmAlgorithmExpert radiologistsNetworkDirect matchingDirect matchAccuracyImagesClassificationResearch purposesPerformanceBreast imagingConvolutionEncodingMatchingModelingTraining
2018
Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study
Hruska CB, Geske JR, Swanson TN, Mammel AN, Lake DS, Manduca A, Conners AL, Whaley DH, Scott CG, Carter RE, Rhodes DJ, O’Connor M, Vachon CM. Quantitative background parenchymal uptake on molecular breast imaging and breast cancer risk: a case-control study. Breast Cancer Research 2018, 20: 46. PMID: 29871661, PMCID: PMC5989426, DOI: 10.1186/s13058-018-0973-3.Peer-Reviewed Original Research
2017
Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging
Swanson TN, Tran TD, Hruska CB, Solberg CM, Rhodes DJ, Hunt KN, Conners AL, O'Connor MK. Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging. Journal Of Medical Imaging And Radiation Sciences 2017, 49: 39-43. PMID: 30479286, DOI: 10.1016/j.jmir.2017.08.003.Peer-Reviewed Original ResearchConceptsMolecular breast imagingExact testFisher's exact testDuration of examinationBreast imagingPatients' opinionsPatient acceptanceDose reductionExamination comfortMost womenPatient comfortFemale volunteersRadiation doseExamination typesDoseExamination preferencesImagingPatientsGroupNumber of strategiesSurvey responsesVolunteersWomen
2016
Benefit-to–Radiation Risk for Breast Screening Tests Is a Flawed Concept
Rhodes DJ, Hruska CB, Conners AL, Hunt KN, O'Connor MK. Benefit-to–Radiation Risk for Breast Screening Tests Is a Flawed Concept. Radiology 2016, 281: 978-980. PMID: 27870632, DOI: 10.1148/radiol.2016161334.Peer-Reviewed Original Research
2015
Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging
Hruska CB, Conners AL, Vachon CM, O'Connor MK, Shuster LT, Bartley AC, Rhodes DJ. Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging. Academic Radiology 2015, 22: 1147-1156. PMID: 26112057, PMCID: PMC4532620, DOI: 10.1016/j.acra.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedMolecular ImagingPremenopauseProgesteroneProspective StudiesRadiopharmaceuticalsSex Hormone-Binding GlobulinTandem Mass SpectrometryTechnetium Tc 99m SestamibiTestosteroneConceptsBackground parenchymal uptakeMolecular breast imagingMenstrual cycle phaseLuteal phaseMenstrual cycleNondense breastsFollicular phaseHormone levelsParenchymal uptakeDense breastsExogenous hormone useRegular menstrual cyclesLevels of TCCycle phaseNormal fibroglandular tissuePremenopausal volunteersPremenopausal womenHormone useSpearman correlation coefficientBreast imagingStudy radiologistsMammographic densityBreastFibroglandular tissueWomenAwareness of Breast Density and Its Impact on Breast Cancer Detection and Risk
Rhodes DJ, Radecki Breitkopf C, Ziegenfuss JY, Jenkins SM, Vachon CM. Awareness of Breast Density and Its Impact on Breast Cancer Detection and Risk. Journal Of Clinical Oncology 2015, 33: 1143-1150. PMID: 25732156, PMCID: PMC4551864, DOI: 10.1200/jco.2014.57.0325.Peer-Reviewed Original ResearchMeSH KeywordsAwarenessBlack or African AmericanBreastBreast NeoplasmsCross-Sectional StudiesEarly Detection of CancerEducational StatusFemaleHealth Knowledge, Attitudes, PracticeHealthcare DisparitiesHispanic or LatinoHumansLogistic ModelsMammographyMass ScreeningMiddle AgedMultivariate AnalysisRisk FactorsSocial ClassUnited StatesWhite PeopleConceptsRace/ethnicityBD awarenessWhite non-Hispanic race/ethnicityCancer detectionPostmenopausal hormone therapyNational cross-sectional surveyNon-Hispanic race/ethnicityPrior breast biopsyBreast cancer detectionHealth care providersCross-sectional surveyBreast density informationMultivariable adjustmentHormone therapyDiagnostic evaluationCancer riskCare providersBreast biopsyConnecticut residentsBreast densityHigher household incomeProbability-based sampleHousehold incomeWomenRiskFactors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
O’Connor M, Hruska CB, Tran TD, Swanson T, Conners AL, Jones K, Rhodes DJ. Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2015, 43: 13-20. PMID: 25613340, DOI: 10.2967/jnmt.114.150128.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast tissuePrandial statusOptimal patient preparationPeripheral blood flowBody surface areaCounts/Type of interventionBreast imagingPatient heightPeripheral warmingStudy groupBlood flowSestamibiBreast activityPatient preparationFed stateCount densityMetabolic statusReference groupOblique viewMediolateral oblique viewTissueInterventionBreast thickness
2014
Breast density legislation. Implications for patients and primary care providers.
Rhodes DJ, Conners AL. Breast density legislation. Implications for patients and primary care providers. Minnesota Medicine 2014, 97: 43-8. PMID: 25158436.Peer-Reviewed Original Research
2012
Proof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients
Hruska CB, Weinmann AL, Skjerseth C, Wagenaar EM, Conners AL, Tortorelli CL, Maxwell RW, Rhodes DJ, O'Connor MK. Proof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients. Medical Physics 2012, 39: 3476-3483. PMID: 22755727, PMCID: PMC3376157, DOI: 10.1118/1.4719959.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMBq TcDiagnostic accuracyIntrareader agreementMedian lesion sizeLesion detectionPatient studiesEffective radiation doseTelluride gamma cameraSimilar diagnostic accuracyAdequate lesion detectionAdjunct screening techniqueGamma cameraAdministered dosesCount densityClinical careSeparate cohortLesion sizeMBq injectionMolecular breastLow dosesPatientsDense breastsBreast lesionsDosesThe Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer
Wahner-Roedler DL, Boughey JC, Hruska CB, Chen B, Rhodes DJ, Tortorelli CL, Maxwell RW, S. S, O'Connor MK. The Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer. Clinical Nuclear Medicine 2012, 37: 344-350. PMID: 22391702, PMCID: PMC3296091, DOI: 10.1097/rlu.0b013e31824437b3.Peer-Reviewed Original ResearchConceptsMolecular breast imagingNeoadjuvant therapyTumor sizeBreast cancerResidual tumor sizeProspective pilot studyInvasive breast cancerBreast cancer treatmentTumor-specific radiopharmaceuticalsPathologic extentResidual diseasePretreatment valuesTumor responseTumor extentPosttreatment valuesIntravenous injectionPathologic measurementsRadiotracer uptakePredictive valueMolecular breastPatientsCancerCancer treatmentPilot studyInterest analysisEvaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi
Hruska CB, Rhodes DJ, Collins DA, Tortorelli CL, Askew JW, O'Connor MK. Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi. Journal Of Women's Health 2012, 21: 730-738. PMID: 22404787, DOI: 10.1089/jwh.2011.3267.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast diseaseBreast cancerDiagnostic yieldMyocardial perfusionHigh-risk benign breast lesionsMyocardial perfusion stress testingRecent negative mammogramStress myocardial perfusionHigh diagnostic yieldStress myocardial perfusion studyBenign breast lesionsNumber of cancersMyocardial perfusion studiesBreast imagingNew cancersRecent mammogramSestamibi injectionNegative mammogramUnnecessary workupPerfusion studiesBreast lesionsCancerIsotope injectionWomenLexicon for standardized interpretation of gamma camera molecular breast imaging: observer agreement and diagnostic accuracy
Conners AL, Hruska CB, Tortorelli CL, Maxwell RW, Rhodes DJ, Boughey JC, Berg WA. Lexicon for standardized interpretation of gamma camera molecular breast imaging: observer agreement and diagnostic accuracy. European Journal Of Nuclear Medicine And Molecular Imaging 2012, 39: 971-982. PMID: 22289959, DOI: 10.1007/s00259-011-2054-z.Peer-Reviewed Original Research
2010
Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)
O'Connor MK, Li H, Rhodes DJ, Hruska CB, Clancy CB, Vetter RJ. Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta). Medical Physics 2010, 37: 6187-6198. PMID: 21302775, PMCID: PMC2997811, DOI: 10.1118/1.3512759.Peer-Reviewed Original ResearchConceptsBenefit/risk ratioMolecular breast imagingCumulative cancer incidenceCancer incidenceRisk ratioAge groupsExcess absolute risk (EAR) modelsAnnual digital mammographyAttributable risk modelRadiation-induced cancer riskBreast cancer incidenceBreast-specific gammaPositron emission mammographyBEIR VII reportRadiation-induced cancerDense breast tissueAbsolute risk modelsMBq FScreening groupAnnual screeningConventional dosesMBq TcLifetime riskBreast cancerAge 40
2003
Evaluation of a small cadmium zinc telluride detector for scintimammography.
Mueller B, O'Connor MK, Blevis I, Rhodes DJ, Smith R, Collins DA, Phillips SW. Evaluation of a small cadmium zinc telluride detector for scintimammography. Journal Of Nuclear Medicine 2003, 44: 602-9. PMID: 12679406.Peer-Reviewed Original ResearchConceptsSmall glass spheresCZT detectorsCadmium zinc telluride detectorsGlass spheresWater tankDetector elementsCZT systemBreast phantom imagesEffect of variationTelluride detectorIntegral uniformitySpatial resolutionSuperior performanceField of viewSmall spheresCameraConventional gamma cameraPhantom modelLarge fieldPerformanceResolution collimatorEnergy resolutionRange 0CollimatorTank