2019
Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testIntervention
2017
Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging
Swanson TN, Tran TD, Hruska CB, Solberg CM, Rhodes DJ, Hunt KN, Conners AL, O'Connor MK. Patient Acceptance of Half-dose Vs. Half-time Molecular Breast Imaging. Journal Of Medical Imaging And Radiation Sciences 2017, 49: 39-43. PMID: 30479286, DOI: 10.1016/j.jmir.2017.08.003.Peer-Reviewed Original ResearchConceptsMolecular breast imagingExact testFisher's exact testDuration of examinationBreast imagingPatients' opinionsPatient acceptanceDose reductionExamination comfortMost womenPatient comfortFemale volunteersRadiation doseExamination typesDoseExamination preferencesImagingPatientsGroupNumber of strategiesSurvey responsesVolunteersWomen
2015
Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology.
Conners AL, Jones KN, Hruska CB, Geske JR, Boughey JC, Rhodes DJ. Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology. American Journal Of Roentgenology 2015, 205: w374-81. PMID: 26295674, PMCID: PMC8900216, DOI: 10.2214/ajr.14.13502.Peer-Reviewed Original ResearchConceptsInvasive breast cancerMolecular breast imagingInvasive tumor fociBreast imaging examinationsTumor fociMolecular breastBreast cancerImaging featuresInvasive diseasePathology reportsImaging examinationsHistologic profileBreast imagingBreast imaging findingsChi-square testLobular histologyHistologic subtypeInvasive DuctalImaging findingsInvasive cancerBenign reasonsInvasive fociTumor appearanceBlinded reviewLesion typeEffect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging
Hruska CB, Conners AL, Vachon CM, O'Connor MK, Shuster LT, Bartley AC, Rhodes DJ. Effect of Menstrual Cycle Phase on Background Parenchymal Uptake at Molecular Breast Imaging. Academic Radiology 2015, 22: 1147-1156. PMID: 26112057, PMCID: PMC4532620, DOI: 10.1016/j.acra.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultBreastBreast DensityChromatography, LiquidCohort StudiesEstradiolEstroneFemaleFollicle Stimulating HormoneFollicular PhaseHumansLuteal PhaseMammographyMiddle AgedMolecular ImagingPremenopauseProgesteroneProspective StudiesRadiopharmaceuticalsSex Hormone-Binding GlobulinTandem Mass SpectrometryTechnetium Tc 99m SestamibiTestosteroneConceptsBackground parenchymal uptakeMolecular breast imagingMenstrual cycle phaseLuteal phaseMenstrual cycleNondense breastsFollicular phaseHormone levelsParenchymal uptakeDense breastsExogenous hormone useRegular menstrual cyclesLevels of TCCycle phaseNormal fibroglandular tissuePremenopausal volunteersPremenopausal womenHormone useSpearman correlation coefficientBreast imagingStudy radiologistsMammographic densityBreastFibroglandular tissueWomenDiagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts.
Hruska CB, Conners AL, Jones KN, O'Connor MK, Moriarty JP, Boughey JC, Rhodes DJ. Diagnostic workup and costs of a single supplemental molecular breast imaging screen of mammographically dense breasts. American Journal Of Roentgenology 2015, 204: 1345-53. PMID: 26001247, PMCID: PMC5036572, DOI: 10.2214/ajr.14.13306.Peer-Reviewed Original ResearchConceptsBenign biopsy rateDiagnostic workupBiopsy rateDense breastsAdditional diagnostic workupCancer detection rateMammography of womenBreast imaging examinationsPositive predictive valueDual-head gamma cameraImaging examinationsPredictive valueMolecular breastBiopsyPatientsWorkupBreastScreening mammographyCancerWomenMammographyMalignancyReference standardGamma cameraDetection rateFactors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging
O’Connor M, Hruska CB, Tran TD, Swanson T, Conners AL, Jones K, Rhodes DJ. Factors Influencing the Uptake of 99mTc-Sestamibi in Breast Tissue on Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2015, 43: 13-20. PMID: 25613340, DOI: 10.2967/jnmt.114.150128.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiological TransportBlood CirculationBreastCaffeineExerciseFastingFemaleHumansMolecular ImagingRestTechnetium Tc 99m SestamibiConceptsMolecular breast imagingBreast tissuePrandial statusOptimal patient preparationPeripheral blood flowBody surface areaCounts/Type of interventionBreast imagingPatient heightPeripheral warmingStudy groupBlood flowSestamibiBreast activityPatient preparationFed stateCount densityMetabolic statusReference groupOblique viewMediolateral oblique viewTissueInterventionBreast thickness
2012
Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi
Hruska CB, Rhodes DJ, Collins DA, Tortorelli CL, Askew JW, O'Connor MK. Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi. Journal Of Women's Health 2012, 21: 730-738. PMID: 22404787, DOI: 10.1089/jwh.2011.3267.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast diseaseBreast cancerDiagnostic yieldMyocardial perfusionHigh-risk benign breast lesionsMyocardial perfusion stress testingRecent negative mammogramStress myocardial perfusionHigh diagnostic yieldStress myocardial perfusion studyBenign breast lesionsNumber of cancersMyocardial perfusion studiesBreast imagingNew cancersRecent mammogramSestamibi injectionNegative mammogramUnnecessary workupPerfusion studiesBreast lesionsCancerIsotope injectionWomen
2010
Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection
2008
Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors.
Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O'Connor MK. Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors. American Journal Of Roentgenology 2008, 191: 1805-15. PMID: 19020253, PMCID: PMC3885170, DOI: 10.2214/ajr.07.3693.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsEquipment DesignEquipment Failure AnalysisFemaleGamma CamerasHumansImage EnhancementMiddle AgedMolecular Probe TechniquesRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySingle-Blind MethodTechnetium Tc 99m SestamibiConceptsMolecular breast imagingMolecular breastBI-RADS category 4Breast imagingMBq of technetiumSmall breast tumorsTelluride gamma cameraGamma cameraSubcentimeter lesionsUptake scoreAdditional cancersBlinded reviewDetection of cancerBreast tumorsLesionsSmall lesionsBreastPatientsBreast lesionsBlinded readersCancerOblique viewCategory 4Mediolateral oblique viewTumorsScientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience
Hruska CB, Boughey JC, Phillips SW, Rhodes DJ, Wahner-Roedler DL, Whaley DH, Degnim AC, O'Connor MK. Scientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience. The American Journal Of Surgery 2008, 196: 470-476. PMID: 18723155, PMCID: PMC2603338, DOI: 10.1016/j.amjsurg.2008.06.005.Peer-Reviewed Original ResearchConceptsMolecular breast imagingInvasive ductal carcinomaInvasive lobular carcinomaDuctal carcinomaLobular carcinomaHigh-risk patientsExtent of diseaseMayo Clinic experienceBreast cancer screeningSurgical treatment planningBreast imagingMultifocal diseaseCancer screeningInstitutional protocolAdditional diseaseClinic experienceCarcinomaDiseaseFunctional uptakeTreatment planningMBI studiesPromising roleTumorsBreastCancer detection
2007
Molecular Breast Imaging: Advantages and Limitations of a Scintimammographic Technique in Patients with Small Breast Tumors
O'Connor MK, Phillips SW, Hruska CB, Rhodes DJ, Collins DA. Molecular Breast Imaging: Advantages and Limitations of a Scintimammographic Technique in Patients with Small Breast Tumors. The Breast Journal 2007, 13: 3-11. PMID: 17214787, DOI: 10.1111/j.1524-4741.2006.00356.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBreast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCarcinoma, PapillaryFemaleHumansMammographyMiddle AgedPredictive Value of TestsRadionuclide ImagingSensitivity and SpecificityTechnetium Tc 99m SestamibiUltrasonographyConceptsMolecular breast imagingSmall breast tumorsBreast tumorsEvidence of cancerFalse-positive scansLarger patient populationMalignant breast tumorsStandard mammographic viewsMBq TcOccult tumorsPatient populationMalignant tumorsPositive scansPatientsTumorsBreast tissueSubjective discomfortBiopsySurgeryMammographic viewsGamma cameraBreast imagingBreast thicknessPreliminary studyRegular detection
2005
Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast
Rhodes DJ, O'Connor MK, Phillips SW, Smith RL, Collins DA. Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast. Mayo Clinic Proceedings 2005, 80: 24-30. DOI: 10.4065/80.1.24.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMalignant lesionsTechnetium TcBreast parenchymaEvidence of cancerTrue-negative scansFalse-positive scansSensitivity of mammographyTelluride gamma cameraMagnetic resonance imagingTrue positive casesMalignant breast lesionsGamma cameraFat necrosisFalse-positive resultsSmall cancersAdditional lesionsDetection of lesionsSmall tumorsPatientsBenign fibroadenomasLesionsResonance imagingBreast contralateralSurgery