2019
Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study
Hruska CB, Hunt KN, Conners AL, Geske JR, Brandt KR, Degnim AC, Vachon CM, O’Connor M, Rhodes DJ. Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study. Breast Cancer Research 2019, 21: 38. PMID: 30850011, PMCID: PMC6408779, DOI: 10.1186/s13058-019-1120-5.Peer-Reviewed Original ResearchConceptsLow-dose tamoxifenMolecular breast imagingBackground parenchymal uptakeOral tamoxifenParenchymal uptakeBreast cancer risk reductionBreast cancer risk factorsEffectiveness of tamoxifenCancer risk factorsCancer risk reductionBreast cancer historyShort-term interventionMean ageCancer historyRisk factorsBreast fibroglandular tissueTamoxifenMolecular breastAverage countStudy participantsSubcutaneous fatPilot studyWomenT-testIntervention
2012
Gamma camera breast imaging lexicon.
Conners AL, Maxwell RW, Tortorelli CL, Hruska CB, Rhodes DJ, Boughey JC, Berg WA. Gamma camera breast imaging lexicon. American Journal Of Roentgenology 2012, 199: w767-74. PMID: 23169751, DOI: 10.2214/ajr.11.8298.Peer-Reviewed Original ResearchProof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients
Hruska CB, Weinmann AL, Skjerseth C, Wagenaar EM, Conners AL, Tortorelli CL, Maxwell RW, Rhodes DJ, O'Connor MK. Proof of concept for low‐dose molecular breast imaging with a dual‐head CZT gamma camera. Part II. Evaluation in patients. Medical Physics 2012, 39: 3476-3483. PMID: 22755727, PMCID: PMC3376157, DOI: 10.1118/1.4719959.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMBq TcDiagnostic accuracyIntrareader agreementMedian lesion sizeLesion detectionPatient studiesEffective radiation doseTelluride gamma cameraSimilar diagnostic accuracyAdequate lesion detectionAdjunct screening techniqueGamma cameraAdministered dosesCount densityClinical careSeparate cohortLesion sizeMBq injectionMolecular breastLow dosesPatientsDense breastsBreast lesionsDoses
2010
Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection
2008
Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors.
Hruska CB, Phillips SW, Whaley DH, Rhodes DJ, O'Connor MK. Molecular breast imaging: use of a dual-head dedicated gamma camera to detect small breast tumors. American Journal Of Roentgenology 2008, 191: 1805-15. PMID: 19020253, PMCID: PMC3885170, DOI: 10.2214/ajr.07.3693.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBreast NeoplasmsEquipment DesignEquipment Failure AnalysisFemaleGamma CamerasHumansImage EnhancementMiddle AgedMolecular Probe TechniquesRadionuclide ImagingRadiopharmaceuticalsReproducibility of ResultsSensitivity and SpecificitySingle-Blind MethodTechnetium Tc 99m SestamibiConceptsMolecular breast imagingMolecular breastBI-RADS category 4Breast imagingMBq of technetiumSmall breast tumorsTelluride gamma cameraGamma cameraSubcentimeter lesionsUptake scoreAdditional cancersBlinded reviewDetection of cancerBreast tumorsLesionsSmall lesionsBreastPatientsBreast lesionsBlinded readersCancerOblique viewCategory 4Mediolateral oblique viewTumorsScientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience
Hruska CB, Boughey JC, Phillips SW, Rhodes DJ, Wahner-Roedler DL, Whaley DH, Degnim AC, O'Connor MK. Scientific Impact Recognition Award: Molecular breast imaging: A review of the Mayo Clinic experience. The American Journal Of Surgery 2008, 196: 470-476. PMID: 18723155, PMCID: PMC2603338, DOI: 10.1016/j.amjsurg.2008.06.005.Peer-Reviewed Original ResearchConceptsMolecular breast imagingInvasive ductal carcinomaInvasive lobular carcinomaDuctal carcinomaLobular carcinomaHigh-risk patientsExtent of diseaseMayo Clinic experienceBreast cancer screeningSurgical treatment planningBreast imagingMultifocal diseaseCancer screeningInstitutional protocolAdditional diseaseClinic experienceCarcinomaDiseaseFunctional uptakeTreatment planningMBI studiesPromising roleTumorsBreastCancer detection
2005
Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast
Rhodes DJ, O'Connor MK, Phillips SW, Smith RL, Collins DA. Molecular Breast Imaging: A New Technique Using Technetium Tc 99m Scintimammography to Detect Small Tumors of the Breast. Mayo Clinic Proceedings 2005, 80: 24-30. DOI: 10.4065/80.1.24.Peer-Reviewed Original ResearchConceptsMolecular breast imagingMalignant lesionsTechnetium TcBreast parenchymaEvidence of cancerTrue-negative scansFalse-positive scansSensitivity of mammographyTelluride gamma cameraMagnetic resonance imagingTrue positive casesMalignant breast lesionsGamma cameraFat necrosisFalse-positive resultsSmall cancersAdditional lesionsDetection of lesionsSmall tumorsPatientsBenign fibroadenomasLesionsResonance imagingBreast contralateralSurgery
2003
Evaluation of a small cadmium zinc telluride detector for scintimammography.
Mueller B, O'Connor MK, Blevis I, Rhodes DJ, Smith R, Collins DA, Phillips SW. Evaluation of a small cadmium zinc telluride detector for scintimammography. Journal Of Nuclear Medicine 2003, 44: 602-9. PMID: 12679406.Peer-Reviewed Original ResearchConceptsSmall glass spheresCZT detectorsCadmium zinc telluride detectorsGlass spheresWater tankDetector elementsCZT systemBreast phantom imagesEffect of variationTelluride detectorIntegral uniformitySpatial resolutionSuperior performanceField of viewSmall spheresCameraConventional gamma cameraPhantom modelLarge fieldPerformanceResolution collimatorEnergy resolutionRange 0CollimatorTank