2024
A Survey of Patient Experience During Molecular Breast Imaging
Hruska C, Gray L, Jenkins S, Block E, Hunt K, Conners A, Zingula S, O'Connor M, Rhodes D. A Survey of Patient Experience During Molecular Breast Imaging. Journal Of Nuclear Medicine Technology 2024, 52: jnmt.123.266856. PMID: 38839120, PMCID: PMC11149590, DOI: 10.2967/jnmt.123.266856.Peer-Reviewed Original ResearchPatient experiencePersonal history of breast cancerDense breastsSurvey of patient experienceHistory of breast cancerPositive patient experienceAssociated with respondents' ageImprove patient experienceSoliciting patient feedbackPatient comfort levelMammographically dense breastsPatient feedbackStudy consentMolecular breast imagingNeck discomfortRespondents' agePersonal historyMammographyComfort levelSource of discomfortBreast compressionBreast cancerEvaluating patientsInfluence willingnessRespondents
2023
Breast Cancer Mode of Detection in a Population-Based Cohort
Basappa S, Finney Rutten L, Hruska C, Olson J, Jacobson D, Rhodes D. Breast Cancer Mode of Detection in a Population-Based Cohort. Mayo Clinic Proceedings 2023, 98: 278-289. PMID: 36737116, PMCID: PMC9907001, DOI: 10.1016/j.mayocp.2022.10.010.Peer-Reviewed Original ResearchConceptsPopulation-based cohortBreast cancerAdvanced cancerBreast densityRetrospective medical record reviewDense breastsPositive lymph nodesFirst-time diagnosisRochester Epidemiology ProjectMedical record reviewStage of diseaseLarger tumor sizeWomen age 40High-grade tumorsMultiple logistic regressionYears of ageLymph nodesRecord reviewTumor characteristicsTumor sizeCancer characteristicsCancer modeAge 40Clinical attentionCancer
2021
Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study.
Hruska CB, Geske JR, Conners AL, Whaley DH, Rhodes DJ, O'Connor MK, Carter RE, Scott CG, Vachon CM. Background Parenchymal Uptake on Molecular Breast Imaging and Breast Cancer Risk: A Cohort Study. American Journal Of Roentgenology 2021, 216: 1193-1204. PMID: 32755210, PMCID: PMC8640999, DOI: 10.2214/ajr.20.23854.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeMolecular breast imagingPostmenopausal womenBreast cancer riskAbsolute riskBreast cancerCohort studyDiscriminatory accuracyDense breastsRisk factorsParenchymal uptakeCancer riskRisk scoreFuture breast cancer diagnosisGreater breast cancer riskBreast cancer risk factorsCox proportional hazards modelGail risk scoreBreast cancer eventsIndependent risk factorSubset of womenCancer risk factorsCase-control studyProportional hazards modelBreast cancer diagnosis
2019
Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial
Patel BK, Ridgeway JL, Ghosh K, Rhodes DJ, Borah B, Jenkins S, Suman VJ, Norman A, Jewett M, Singh D, Vachon CM, Radecki Breitkopf C. Behavioral and psychological impact of returning breast density results to Latinas: study protocol for a randomized clinical trial. Trials 2019, 20: 744. PMID: 31852492, PMCID: PMC6921571, DOI: 10.1186/s13063-019-3939-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnxietyBreast DensityBreast NeoplasmsEarly Detection of CancerFemaleHealth CommunicationHealth Knowledge, Attitudes, PracticeHealth LiteracyHispanic or LatinoHumansMammographyMass ScreeningMiddle AgedPatient CompliancePatient Education as TopicQualitative ResearchRandomized Controlled Trials as TopicConceptsRandomized clinical trialsMammographic breast densityLimited resource settingsClinical trialsHealth literacyBreast densityWHO Trial Registration Data SetLatina womenTrial Registration Data SetLimited health literacyLow health literacyBreast cancer riskCancer risk communicationPsychological outcomesMeasurement time pointsDiagnostic delayCancer mortalityBackgroundBreast cancerCommon cancerMammogram resultsStudy protocolCommunity clinicsBreast cancerMammography screeningCancer riskMolecular Breast Imaging in Patients with Suspicious Calcifications
Hunt K, Hruska C, Johnson M, Conners A, O’connor M, Rhodes D, Basappa S, Wahner-Roedler D. Molecular Breast Imaging in Patients with Suspicious Calcifications. Journal Of Breast Imaging 2019, 1: 303-309. PMID: 38424809, DOI: 10.1093/jbi/wbz054.Peer-Reviewed Original ResearchMolecular breast imagingSuspicious calcificationsNegative predictive valueTelluride gamma cameraPredictive valueMedian pathologic sizeInvasive ductal cancerOccult breast cancerInjection of TcAreas of calcificationBreast imagingNuclear medicine techniquesPrebiopsy settingGamma cameraBiopsy findingsDuctal cancerPathologic sizeIncidental lesionsDuctal carcinomaInvasive cancerAdditional biopsiesBreast cancerStereotactic biopsyBiopsyMolecular breast
2017
Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer
O’Connor M, Morrow MMB, Hunt KN, Boughey JC, Wahner-Roedler DL, Conners AL, Rhodes DJ, Hruska CB. Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer. EJNMMI Research 2017, 7: 5. PMID: 28091980, PMCID: PMC5237435, DOI: 10.1186/s13550-017-0255-6.Peer-Reviewed Original ResearchBreast cancerBenign lesionsMolecular subtypesBreast lesionsTumor molecular subtypeOverall diagnostic performancePathologic sizeAnalyzable patientsTumor extentMalignant tumorsLesion extentBlinded fashionLesion sizeSestamibiMolecular breastPatientsLesionsAlternative radiotracersLesion uptakeAssessment scoresROC analysisCancerInterest analysisDiagnostic performanceExamination one
2016
Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study
Hruska CB, Scott CG, Conners AL, Whaley DH, Rhodes DJ, Carter RE, O’Connor M, Hunt KN, Brandt KR, Vachon CM. Background parenchymal uptake on molecular breast imaging as a breast cancer risk factor: a case-control study. Breast Cancer Research 2016, 18: 42. PMID: 27113363, PMCID: PMC4845425, DOI: 10.1186/s13058-016-0704-6.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakeCase-control studyBreast cancer casesRisk factorsBreast cancerCancer casesParenchymal uptakeIncident breast cancer casesBreast cancer risk factorsRetrospective case-control studyDense breastsConditional logistic regression analysisInvasive breast cancer casesPostmenopausal hormone useCancer risk factorsFunctional imaging biomarkersBreast cancer riskLogistic regression analysisBI-RADS densityPostmenopausal womenEligible womenMenopausal statusHormone useMedian ageSupplemental screening
2015
Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology.
Conners AL, Jones KN, Hruska CB, Geske JR, Boughey JC, Rhodes DJ. Direct-Conversion Molecular Breast Imaging of Invasive Breast Cancer: Imaging Features, Extent of Invasive Disease, and Comparison Between Invasive Ductal and Lobular Histology. American Journal Of Roentgenology 2015, 205: w374-81. PMID: 26295674, PMCID: PMC8900216, DOI: 10.2214/ajr.14.13502.Peer-Reviewed Original ResearchConceptsInvasive breast cancerMolecular breast imagingInvasive tumor fociBreast imaging examinationsTumor fociMolecular breastBreast cancerImaging featuresInvasive diseasePathology reportsImaging examinationsHistologic profileBreast imagingBreast imaging findingsChi-square testLobular histologyHistologic subtypeInvasive DuctalImaging findingsInvasive cancerBenign reasonsInvasive fociTumor appearanceBlinded reviewLesion typeBackground parenchymal uptake during molecular breast imaging and associated clinical factors.
Hruska CB, Rhodes DJ, Conners AL, Jones KN, Carter RE, Lingineni RK, Vachon CM. Background parenchymal uptake during molecular breast imaging and associated clinical factors. American Journal Of Roentgenology 2015, 204: w363-70. PMID: 25714323, PMCID: PMC4423612, DOI: 10.2214/ajr.14.12979.Peer-Reviewed Original ResearchConceptsBackground parenchymal uptakePostmenopausal hormone therapyParenchymal uptakeBreast cancerMolecular breast imagingHormone therapyClinical factorsMammographic densityDense breastsBI-RADS density categoriesChi-square testMenopausal statusPatient characteristicsHormonal contraceptivesEligible participantsGail modelMenstrual cycleSubsequent riskPrevious mammogramsMolecular breastBreast implantsUnderlying causeCancerBreastWomen
2012
The Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer
Wahner-Roedler DL, Boughey JC, Hruska CB, Chen B, Rhodes DJ, Tortorelli CL, Maxwell RW, S. S, O'Connor MK. The Use of Molecular Breast Imaging to Assess Response in Women Undergoing Neoadjuvant Therapy for Breast Cancer. Clinical Nuclear Medicine 2012, 37: 344-350. PMID: 22391702, PMCID: PMC3296091, DOI: 10.1097/rlu.0b013e31824437b3.Peer-Reviewed Original ResearchConceptsMolecular breast imagingNeoadjuvant therapyTumor sizeBreast cancerResidual tumor sizeProspective pilot studyInvasive breast cancerBreast cancer treatmentTumor-specific radiopharmaceuticalsPathologic extentResidual diseasePretreatment valuesTumor responseTumor extentPosttreatment valuesIntravenous injectionPathologic measurementsRadiotracer uptakePredictive valueMolecular breastPatientsCancerCancer treatmentPilot studyInterest analysisEvaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi
Hruska CB, Rhodes DJ, Collins DA, Tortorelli CL, Askew JW, O'Connor MK. Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi. Journal Of Women's Health 2012, 21: 730-738. PMID: 22404787, DOI: 10.1089/jwh.2011.3267.Peer-Reviewed Original ResearchConceptsMolecular breast imagingBreast diseaseBreast cancerDiagnostic yieldMyocardial perfusionHigh-risk benign breast lesionsMyocardial perfusion stress testingRecent negative mammogramStress myocardial perfusionHigh diagnostic yieldStress myocardial perfusion studyBenign breast lesionsNumber of cancersMyocardial perfusion studiesBreast imagingNew cancersRecent mammogramSestamibi injectionNegative mammogramUnnecessary workupPerfusion studiesBreast lesionsCancerIsotope injectionWomen
2010
Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)
O'Connor MK, Li H, Rhodes DJ, Hruska CB, Clancy CB, Vetter RJ. Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta). Medical Physics 2010, 37: 6187-6198. PMID: 21302775, PMCID: PMC2997811, DOI: 10.1118/1.3512759.Peer-Reviewed Original ResearchConceptsBenefit/risk ratioMolecular breast imagingCumulative cancer incidenceCancer incidenceRisk ratioAge groupsExcess absolute risk (EAR) modelsAnnual digital mammographyAttributable risk modelRadiation-induced cancer riskBreast cancer incidenceBreast-specific gammaPositron emission mammographyBEIR VII reportRadiation-induced cancerDense breast tissueAbsolute risk modelsMBq FScreening groupAnnual screeningConventional dosesMBq TcLifetime riskBreast cancerAge 40Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts
Rhodes DJ, Hruska CB, Phillips SW, Whaley DH, O'Connor MK. Dedicated Dual-Head Gamma Imaging for Breast Cancer Screening in Women with Mammographically Dense Breasts. Radiology 2010, 258: 106-18. PMID: 21045179, DOI: 10.1148/radiol.10100625.Peer-Reviewed Original ResearchConceptsPositive predictive valueBreast cancerDense breastsDiagnostic yieldNode-negative breast cancerAdditional risk factorsNumber of patientsGamma imagingNumber of biopsiesBreast cancer screeningHIPAA-compliant protocolIpsilateral cancerAbnormal findingsAsymptomatic womenEligible participantsCancer screeningRisk factorsSestamibi injection
2002
Identifying and Counseling Women at Increased Risk for Breast Cancer
Rhodes DJ. Identifying and Counseling Women at Increased Risk for Breast Cancer. Mayo Clinic Proceedings 2002, 77: 355-361. PMID: 11936931, DOI: 10.4065/77.4.355.Peer-Reviewed Original ResearchConceptsBreast cancerRisk factorsBreast cancer prevention clinical trialsCancer prevention clinical trialsPossible risk factorsPrevention clinical trialsRisk reductionRisk assessment toolLifestyle modificationProphylactic mastectomyClose surveillanceClinical trialsFamily historyCounseling womenNumerical risk estimatesCancerRisk estimatesIndividual riskSuch womenWomenRiskAbsence of consensusComplex family historiesAssessment toolOptions
2000
Breast cancer prevention trials
Rhodes D, Hartmann L, Perez E. Breast cancer prevention trials. Current Oncology Reports 2000, 2: 558-565. PMID: 11122893, DOI: 10.1007/s11912-000-0110-0.Peer-Reviewed Original ResearchConceptsBreast Cancer Prevention TrialCancer Prevention TrialBreast cancer incidenceBreast cancerPrevention trialsCancer incidenceBowel Project Breast Cancer Prevention TrialPrimary breast cancer preventionNational Surgical Adjuvant BreastEffectiveness of raloxifeneEfficacy of tamoxifenBreast cancer preventionHormone replacement therapyAdjuvant BreastPostmenopausal womenRandomized trialsReplacement therapyDrug therapyCancer preventionStudy populationEligibility criteriaChemopreventive agentsTamoxifenTreatment planRaloxifene