1998
Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline
Markham R, Wang W, Weisstein A, Wang Z, Munoz A, Templeton A, Margolick J, Vlahov D, Quinn T, Farzadegan H, Yu X. Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12568-12573. PMID: 9770526, PMCID: PMC22871, DOI: 10.1073/pnas.95.21.12568.Peer-Reviewed Original ResearchConceptsCD4 T-cell declineT-cell declineCell declineHIV-1 env sequencesFirst seropositive visitModerate disease progressionCD4 T cellsInjection drug usersLow viral loadHIV-1 evolutionLater time pointsViral loadDisease progressionT cellsDrug usersPredominant virusNonsynonymous mutationsEnv sequencesTime pointsNonprogressorsTypes of mutationsDominant variantVisitsOnly quantitative differencesViral evolution
1995
Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes.
Holmberg S, Conley L, Luby S, Cohn S, Wong L, Vlahov D. Recent Infection with Human Immunodeficiency Virus and Possible Rapid Loss of CD4 T Lymphocytes. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1995, 9: 291. PMID: 7788428, DOI: 10.1097/00042560-199507000-00011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCD4 T lymphocytesObservational cohort studyT lymphocytesCell countHIV seroconversionCohort studyHIV infectionImmunodeficiency virusOngoing observational cohort studyEarlier calendar yearsMore rapid declineLow CD4Mean CD4Recent infectionHIV-1CD4Drug usersBisexual menInfectionSeroconversionCalendar yearLymphocytesRapid lossFirst year