1998
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1996
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean M, Carrington M, Winkler C, Huttley G, Smith M, Allikmets R, Goedert J, Buchbinder S, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien S. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science 1996, 273: 1856-1862. PMID: 8791590, DOI: 10.1126/science.273.5283.1856.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 3Cohort StudiesDisease ProgressionGenesHemophilia AHeterozygoteHIV InfectionsHIV-1Homosexuality, MaleHomozygoteHumansImmunity, InnateMaleMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVRisk FactorsSequence DeletionSurvival AnalysisConceptsHIV-1 infectionHIV-1-infected individualsAntibody-negative individualsCohort studyRapid progressorsHuman immunodeficiencyDisease progressionRisk groupsT lymphocytesGenetic restrictionSurvival analysisInfected individualsDeletion alleleCaucasian populationInfectionAIDSProgressionHuman chromosome 3p21Secondary receptorGroup of individualsChromosome 3p21Certain strainsDeletion homozygotesIndividualsProgressors