2002
Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS)
Downer M, Hodge T, Smith D, Qari S, Schuman P, Mayer K, Klein R, Vlahov D, Gardner L, McNicholl J. Regional variation in CCR5-Δ32 gene distribution among women from the US HIV Epidemiology Research Study (HERS). Genes & Immunity 2002, 3: 295-298. PMID: 12140749, DOI: 10.1038/sj.gene.6363884.Peer-Reviewed Original ResearchConceptsHIV Epidemiology Research StudyRace/ethnicityHIV-1HIV Epidemiologic Research StudyAfrican AmericansCCR5-Δ32 genotypeHIV-1 transmissionEpidemiologic research studiesHost genetic factorsHispanic/LatinaBlack/African AmericanUninfected womenAA womenUS womenCCR5-Δ32US populationWhite womenFrequency of heterozygotesWomenGenetic factorsDistributions of heterozygotesRegional variationResearch studies
1998
Diversification of Subtype E Human Immunodeficiency Virus Type 1 env in Heterosexual Seroconverters from Northern Thailand
Wang Z, Lyles C, Beyrer C, Celentano D, Vlahov D, Natpratan C, Markham R, Khamboonruang C, Nelson K, Yu X. Diversification of Subtype E Human Immunodeficiency Virus Type 1 env in Heterosexual Seroconverters from Northern Thailand. The Journal Of Infectious Diseases 1998, 178: 1507-1511. PMID: 9780276, DOI: 10.1086/314441.Peer-Reviewed Original ResearchConceptsHIV-1 infectionAsymptomatic HIV-1-infected subjectsHIV-1 subtype EHIV-1-infected subjectsHuman Immunodeficiency Virus Type 1 EnvSubtype E HIVC2-V3 regionHuman immunodeficiency virusHIV vaccine developmentInjection drug usersE HIVRecent seroconvertersImmunodeficiency virusSubtype ESeroconvertersHIV-1Drug usersVaccine developmentMolecular epidemiologyEnv sequencesInfectionEnvNorthern ThailandHIVBaltimorePatterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline
Markham R, Wang W, Weisstein A, Wang Z, Munoz A, Templeton A, Margolick J, Vlahov D, Quinn T, Farzadegan H, Yu X. Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12568-12573. PMID: 9770526, PMCID: PMC22871, DOI: 10.1073/pnas.95.21.12568.Peer-Reviewed Original ResearchConceptsCD4 T-cell declineT-cell declineCell declineHIV-1 env sequencesFirst seropositive visitModerate disease progressionCD4 T cellsInjection drug usersLow viral loadHIV-1 evolutionLater time pointsViral loadDisease progressionT cellsDrug usersPredominant virusNonsynonymous mutationsEnv sequencesTime pointsNonprogressorsTypes of mutationsDominant variantVisitsOnly quantitative differencesViral evolution
1996
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Dean M, Carrington M, Winkler C, Huttley G, Smith M, Allikmets R, Goedert J, Buchbinder S, Vittinghoff E, Gomperts E, Donfield S, Vlahov D, Kaslow R, Saah A, Rinaldo C, Detels R, O'Brien S. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science 1996, 273: 1856-1862. PMID: 8791590, DOI: 10.1126/science.273.5283.1856.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBase SequenceChromosome MappingChromosomes, Human, Pair 3Cohort StudiesDisease ProgressionGenesHemophilia AHeterozygoteHIV InfectionsHIV-1Homosexuality, MaleHomozygoteHumansImmunity, InnateMaleMolecular Sequence DataReceptors, CCR5Receptors, CytokineReceptors, HIVRisk FactorsSequence DeletionSurvival AnalysisConceptsHIV-1 infectionHIV-1-infected individualsAntibody-negative individualsCohort studyRapid progressorsHuman immunodeficiencyDisease progressionRisk groupsT lymphocytesGenetic restrictionSurvival analysisInfected individualsDeletion alleleCaucasian populationInfectionAIDSProgressionHuman chromosome 3p21Secondary receptorGroup of individualsChromosome 3p21Certain strainsDeletion homozygotesIndividualsProgressors
1995
Correlates of Hepatitis C Virus Infections among Injection Drug Users
Thomas D, Vlahov D, Solomon L, Cohn S, Taylor E, Garfein R, Nelson K. Correlates of Hepatitis C Virus Infections among Injection Drug Users. Medicine 1995, 74: 212-220. PMID: 7623656, DOI: 10.1097/00005792-199507000-00005.Peer-Reviewed Original ResearchConceptsInjection drug usersHepatitis C virus infectionC virus infectionHuman immunodeficiency virusHCV infectionDrug usersVirus infectionMajority of HCVYears of injectingLong-term drug usersHCV RNASerologic evidenceImmunodeficiency virusBloodborne pathogensInjection drugsViral persistenceImmune responsePersistent infectionHigh riskHCVDrug useBiologic basisStudy participantsInfectionIllicit drugsHuman Immunodeficiency Virus Type 1 env and p17gag Sequence Variation in Polymerase Chain Reaction-Positive, Seronegative Injection Drug Users
Markham R, Yu X, Farzadegan H, Ray S, Vlahov D. Human Immunodeficiency Virus Type 1 env and p17gag Sequence Variation in Polymerase Chain Reaction-Positive, Seronegative Injection Drug Users. The Journal Of Infectious Diseases 1995, 171: 797-804. PMID: 7706805, DOI: 10.1093/infdis/171.4.797.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCross-Sectional StudiesDNA, ViralFemaleGag Gene Products, Human Immunodeficiency VirusGene Products, envGene Products, gagGenes, envGenes, gagGenetic VariationHIV AntigensHIV InfectionsHIV-1HumansMaleMolecular Sequence DataPhylogenyPolymerase Chain ReactionSequence AlignmentSequence Analysis, DNASubstance Abuse, IntravenousViral ProteinsConceptsSeronegative injection drug usersInjection drug usersDrug usersHuman Immunodeficiency Virus Type 1 EnvCross-sectional studyPolymerase chainHIV-1 genesThird hypervariable regionAbility of virusesV3 loopMucosal surfacesIntersubject variationEnvelope regionInfected cellsAmino acid variationsEnvP17gagSeminal fluidVirusAcid variationsHypervariable regionInfectionDisease
1991
Diagnosis and differentiation of HTLV-I and HTLV-II infection by enzyme immunoassays using synthetic peptides.
Viscidi R, Hill P, Li S, Cerny E, Vlahov D, Farzadegan H, Halsey N, Kelen G, Quinn T. Diagnosis and differentiation of HTLV-I and HTLV-II infection by enzyme immunoassays using synthetic peptides. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1991, 4: 1190-8. PMID: 1941526.Peer-Reviewed Original ResearchConceptsEnzyme immunoassayHTLV-IIAntibody reactivityPeptide enzyme immunoassayHTLV-II infectionEpidemiology of HTLVDifferentiation of HTLVMicrotiter plate enzyme immunoassaysPattern of reactivitySeronegative controlsEmergency departmentEnv peptidesPositive seraViral infectionNeurological diseasesHTLVSynthetic peptidesInfectionDrug abuseMajor envelope proteinEnvEnvelope proteinPatientsSerumAntibodies