2001
Dynamics of SEN Virus Infection among Injection Drug Users
Wilson L, Umemura T, Astemborski J, Ray S, Alter H, Strathdee S, Vlahov D, Thomas D. Dynamics of SEN Virus Infection among Injection Drug Users. The Journal Of Infectious Diseases 2001, 184: 1315-1319. PMID: 11679921, DOI: 10.1086/324001.Peer-Reviewed Original ResearchConceptsInjection drug usersSEN virusDrug usersSEN virus infectionSENV-H DNASENV-H infectionPosttransfusion hepatitisSENV infectionViral clearancePolymerase chain reactionViral persistenceClinical significanceVirus infectionInfectionSerum samplesChain reactionReinfectionVirusDNA virusesHepatitisClearance
1999
Persistence of viremia and the importance of long‐term follow‐up after acute hepatitis C infection
Villano S, Vlahov D, Nelson K, Cohn S, Thomas D. Persistence of viremia and the importance of long‐term follow‐up after acute hepatitis C infection. Hepatology 1999, 29: 908-914. PMID: 10051497, DOI: 10.1002/hep.510290311.Peer-Reviewed Original ResearchConceptsRecombinant immunoblot assayHCV RNAAcute infectionViral clearanceAcute hepatitis C virus (HCV) infectionAcute hepatitis C infectionHepatitis C virus infectionPersistence of viremiaAcute HCV infectionAcute hepatitis CC virus infectionHepatitis C infectionTime of seroconversionPeak viral titersHealth care providersSingle laboratory testIllicit drug useHCV seroconversionC infectionHCV infectionHepatitis CPersistent viremiaClinical featuresHCV subtypesPolymerase chain reaction
1998
Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline
Markham R, Wang W, Weisstein A, Wang Z, Munoz A, Templeton A, Margolick J, Vlahov D, Quinn T, Farzadegan H, Yu X. Patterns of HIV-1 evolution in individuals with differing rates of CD4 T cell decline. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12568-12573. PMID: 9770526, PMCID: PMC22871, DOI: 10.1073/pnas.95.21.12568.Peer-Reviewed Original ResearchConceptsCD4 T-cell declineT-cell declineCell declineHIV-1 env sequencesFirst seropositive visitModerate disease progressionCD4 T cellsInjection drug usersLow viral loadHIV-1 evolutionLater time pointsViral loadDisease progressionT cellsDrug usersPredominant virusNonsynonymous mutationsEnv sequencesTime pointsNonprogressorsTypes of mutationsDominant variantVisitsOnly quantitative differencesViral evolution
1996
Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells
Markham R, Schwartz D, Templeton A, Margolick J, Farzadegan H, Vlahov D, Yu X. Selective transmission of human immunodeficiency virus type 1 variants to SCID mice reconstituted with human peripheral blood monoclonal cells. Journal Of Virology 1996, 70: 6947-6954. PMID: 8794338, PMCID: PMC190744, DOI: 10.1128/jvi.70.10.6947-6954.1996.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 variantsHu-PBLSCID miceType 1 variantsPrimary isolatesNSI variantsSCID mouse model systemPeripheral blood mononuclear cellsBlood mononuclear cellsHIV-1 variantsMT-2 cellsMouse model systemMononuclear cellsRelative infectiousnessCell culturesVaccine developmentClinical settingMiceEnv sequencesMonoclonal cellsTissue culture systemCellsIsolatesCulture systemPreferential transmission
1995
Human Immunodeficiency Virus Type 1 env and p17gag Sequence Variation in Polymerase Chain Reaction-Positive, Seronegative Injection Drug Users
Markham R, Yu X, Farzadegan H, Ray S, Vlahov D. Human Immunodeficiency Virus Type 1 env and p17gag Sequence Variation in Polymerase Chain Reaction-Positive, Seronegative Injection Drug Users. The Journal Of Infectious Diseases 1995, 171: 797-804. PMID: 7706805, DOI: 10.1093/infdis/171.4.797.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCross-Sectional StudiesDNA, ViralFemaleGag Gene Products, Human Immunodeficiency VirusGene Products, envGene Products, gagGenes, envGenes, gagGenetic VariationHIV AntigensHIV InfectionsHIV-1HumansMaleMolecular Sequence DataPhylogenyPolymerase Chain ReactionSequence AlignmentSequence Analysis, DNASubstance Abuse, IntravenousViral ProteinsConceptsSeronegative injection drug usersInjection drug usersDrug usersHuman Immunodeficiency Virus Type 1 EnvCross-sectional studyPolymerase chainHIV-1 genesThird hypervariable regionAbility of virusesV3 loopMucosal surfacesIntersubject variationEnvelope regionInfected cellsAmino acid variationsEnvP17gagSeminal fluidVirusAcid variationsHypervariable regionInfectionDisease