2004
An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection
Thio C, Goedert J, Mosbruger T, Vlahov D, Strathdee S, O'Brien S, Astemborski J, Thomas D. An analysis of tumor necrosis factor α gene polymorphisms and haplotypes with natural clearance of hepatitis C virus infection. Genes & Immunity 2004, 5: 294-300. PMID: 15071492, DOI: 10.1038/sj.gene.6364072.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionC virus infectionHuman leukocyte antigenHCV infectionSingle nucleotide polymorphismsVirus infectionBlack subjectsTumor Necrosis Factor-α Gene PolymorphismsNecrosis factor-α gene polymorphismsCytokine tumor necrosis factor alphaTNF single nucleotide polymorphismsTumor necrosis factor alphaRole of TNFFunction of TNFΑ gene polymorphismsNecrosis factor alphaCohort of individualsHCV outcomesHCV clearanceViral clearanceLeukocyte antigenViral persistenceFactor alphaImmune responseNatural clearanceMICA and recovery from hepatitis C virus and hepatitis B virus infections
Karacki P, Gao X, Thio C, Thomas D, Goedert J, Vlahov D, Kaslow R, Strathdee S, Hilgartner M, O'Brien S, Carrington M. MICA and recovery from hepatitis C virus and hepatitis B virus infections. Genes & Immunity 2004, 5: 261-266. PMID: 15029237, DOI: 10.1038/sj.gene.6364065.Peer-Reviewed Original ResearchConceptsHepatitis C virusHepatitis B virus infectionChronic hepatitis BB virus infectionHepatitis BC virusVirus infectionMICA polymorphismNatural killer cellsHBV infectionHCV infectionHepatitis CKiller cellsViral clearanceViral persistenceT cellsStudy populationMICA allelesSignificant associationInfectionFurther investigationVirusAssociationPersonsDifferential distribution
2002
HLA-Cw*04 and Hepatitis C Virus Persistence
Thio C, Gao X, Goedert J, Vlahov D, Nelson K, Hilgartner M, O'Brien S, Karacki P, Astemborski J, Carrington M, Thomas D. HLA-Cw*04 and Hepatitis C Virus Persistence. Journal Of Virology 2002, 76: 4792-4797. PMID: 11967296, PMCID: PMC136132, DOI: 10.1128/jvi.76.10.4792-4797.2002.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenHCV infectionViral persistenceAcute hepatitis C virus (HCV) infectionAssociation of HLAHepatitis C virus infectionHepatitis C virus (HCV) persistenceKiller immunoglobulin-like receptorsClass I human leukocyte antigenEarly host immune responseC virus infectionHCV RNA levelsNatural killer cellsImmunoglobulin-like receptorsCytolytic T cellsHost immune responsePolymorphic HLA genesHCV clearanceHCV persistenceKiller cellsViral clearanceLeukocyte antigenPx groupForeign antigensT cells
2001
Dynamics of SEN Virus Infection among Injection Drug Users
Wilson L, Umemura T, Astemborski J, Ray S, Alter H, Strathdee S, Vlahov D, Thomas D. Dynamics of SEN Virus Infection among Injection Drug Users. The Journal Of Infectious Diseases 2001, 184: 1315-1319. PMID: 11679921, DOI: 10.1086/324001.Peer-Reviewed Original ResearchConceptsInjection drug usersSEN virusDrug usersSEN virus infectionSENV-H DNASENV-H infectionPosttransfusion hepatitisSENV infectionViral clearancePolymerase chain reactionViral persistenceClinical significanceVirus infectionInfectionSerum samplesChain reactionReinfectionVirusDNA virusesHepatitisClearanceRacial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes
Thio C, Thomas D, Goedert J, Vlahov D, Nelson K, Hilgartner M, O’Brien S, Karacki P, Marti D, Astemborski J, Carrington M. Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes. The Journal Of Infectious Diseases 2001, 184: 16-21. PMID: 11398104, DOI: 10.1086/321005.Peer-Reviewed Original ResearchConceptsHuman leukocyte antigenClass II associationsViral clearanceClass II HLA typingClass II human leukocyte antigenHepatitis C virus clearanceHLA class II associationsCD4 T cell responsesT cell responsesClass II allelesHepatitis C virus outcomeHCV clearanceLeukocyte antigenVirus clearanceViral persistenceHLA typingImmune responseHomogeneous cohortCell responsesWhite subjectsDiverse cohortCohortClearanceVaried cohortsBlack subjects
1995
Correlates of Hepatitis C Virus Infections among Injection Drug Users
Thomas D, Vlahov D, Solomon L, Cohn S, Taylor E, Garfein R, Nelson K. Correlates of Hepatitis C Virus Infections among Injection Drug Users. Medicine 1995, 74: 212-220. PMID: 7623656, DOI: 10.1097/00005792-199507000-00005.Peer-Reviewed Original ResearchConceptsInjection drug usersHepatitis C virus infectionC virus infectionHuman immunodeficiency virusHCV infectionDrug usersVirus infectionMajority of HCVYears of injectingLong-term drug usersHCV RNASerologic evidenceImmunodeficiency virusBloodborne pathogensInjection drugsViral persistenceImmune responsePersistent infectionHigh riskHCVDrug useBiologic basisStudy participantsInfectionIllicit drugs