2001
Human Immunodeficiency Virus Seroconversion and Evolution of the Hepatitis C Virus Quasispecies
Mao Q, Ray S, Laeyendecker O, Ticehurst J, Strathdee S, Vlahov D, Thomas D. Human Immunodeficiency Virus Seroconversion and Evolution of the Hepatitis C Virus Quasispecies. Journal Of Virology 2001, 75: 3259-3267. PMID: 11238852, PMCID: PMC114119, DOI: 10.1128/jvi.75.7.3259-3267.2001.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHCV quasispeciesHypervariable region 1HIV seroconversionChronic hepatitis C virus (HCV) infectionE2 hypervariable region 1Hepatitis C virus infectionHuman immunodeficiency virus (HIV) seroconversionRapid HIV disease progressionHepatitis C virus quasispeciesHIV infection altersHIV-associated diseaseChronic HCV infectionC virus infectionHIV disease progressionHCV infectionHCV RNASerum levelsLiver diseaseImmunodeficiency virusDisease progressionRapid progressionVirus infectionNumber of subjectsHCV sequences
2000
Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans
An P, Martin M, Nelson G, Carrington M, Smith M, Gong K, Vlahov D, O'Brien S, Winkler C. Influence of CCR5 promoter haplotypes on AIDS progression in African–Americans. AIDS 2000, 14: 2117-2122. PMID: 11061652, DOI: 10.1097/00002030-200009290-00007.Peer-Reviewed Original ResearchConceptsCCR5 promoter haplotypesAIDS progressionSurvival analysisAfrican AmericansNatural history cohort studyPromoter haplotypesRate of progressionPromoter variantsCohort studyCCR5 alleleRapid progressionCaucasian cohortProgressionCaucasiansComplete linkage disequilibriumCCR2AIDSUnidentified polymorphismsRacial groupsLinkage disequilibriumSeroconvertersCCR5CohortHaplotypes
1998
Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users
Yu X, Wang Z, Vlahov D, Markham R, Farzadegan H, Margolick J. Infection with Dual-Tropic Human Immunodeficiency Virus Type 1 Variants Associated with Rapid Total T Cell Decline and Disease Progression in Injection Drug Users. The Journal Of Infectious Diseases 1998, 178: 388-396. PMID: 9697718, DOI: 10.1086/515646.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell LineCells, CulturedDisease ProgressionFemaleGenetic VariationHIV Envelope Protein gp120HIV SeropositivityHIV-1HumansMaleMolecular Sequence DataPeptide FragmentsSequence Homology, Amino AcidSubstance Abuse, IntravenousT-LymphocytesTime FactorsConceptsInjection drug usersSI variantsDisease progressionHuman immunodeficiency virus type 1 variantsDrug usersHuman immunodeficiency virus type 1Immunodeficiency virus type 1HIV-1 transmissionT cell levelsSlow disease progressionT-cell declineDual-tropic virusesType 1 variantsSyncytium-inducing (SI) variantsVirus type 1T cell linesDual tropicNSI variantsSlow progressorsRapid progressionNSI phenotypeT cellsCell declineInitial infectionType 1
1996
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti P, Phillips A, Dorrucci M, Lepri A, Galai N, Vlahov D, Rezza G. Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. The BMJ 1996, 313: 583. PMID: 8806246, PMCID: PMC2352019, DOI: 10.1136/bmj.313.7057.583.Peer-Reviewed Original ResearchConceptsDate of seroconversionCategories of exposureExposure categoriesOlder subjectsInjected drugsMore rapid progressionHeterosexual sexLongitudinal studyHomosexual sexHIV treatmentAIDS pathogenesisUnivariate analysisRapid progressionAge effectsYoung subjectsHomosexual menHIVRate of developmentEvidence of differencesDisease controlAIDSSeroconversionSexAgeDefinitions of Center