2000
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
Shin H, Winkler C, Stephens J, Bream J, Young H, Goedert J, O'Brien T, Vlahov D, Buchbinder S, Giorgi J, Rinaldo C, Donfield S, Willoughby A, O'Brien S, Smith M. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 14467-14472. PMID: 11121048, PMCID: PMC18942, DOI: 10.1073/pnas.97.26.14467.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-1 replicationTranscription factor recognition sequencePromoter allelesLong-term nonprogressorsHIV-1 pathogenesisSingle nucleotide polymorphic variantsOnset of AIDSMacrophages/monocytesNuclear transcription factorSignificant genotype associationsIL10 promoter regionShort tandem repeat polymorphismsTranscription factorsPromoter regionRecognition sequenceIL10 productionInflammatory cytokinesCell cytokinesAIDS cohortC genotypeLymphoid cellsPromoter genotypeGenetic restrictionLymphocyte replicationIncreased Frequency of Overdose Deaths Among HIV-Infected Injection Drug Users
Vlahov D, Tang A, Lyles C, Rezza G, Thomas D, Cohn S, Macalino G, Stambolis V, Nelson K. Increased Frequency of Overdose Deaths Among HIV-Infected Injection Drug Users. Addiction Research & Theory 2000, 8: 311-326. DOI: 10.3109/16066350009009518.Peer-Reviewed Original ResearchInjection drug usersCause-specific mortalityHTV infectionOverdose deathsDrug usersUninfected personsPerson-time techniquesOverall mortality rateFrequency of AIDSOnset of AIDSCorrelates of deathMedian ageHIV serostatusPerson yearsExcess riskDrug overdoseMortality ratePoisson regressionRecord searchUnderlying causeInfectionMortalityDeathAIDSBaseline
1998
Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1992
HIV INFECTION AND AIDS AMONG U.S. PRISON INMATES
Behrendt C, Vlahov D, Clark J, Kendig N. HIV INFECTION AND AIDS AMONG U.S. PRISON INMATES. Journal Of Crime And Justice 1992, 15: 173-186. DOI: 10.1080/0735648x.1992.9721458.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug useVoluntary HIV testingOnset of AIDSCause of deathRisk reduction programsHIV infectionHIV testingHIV-positiveImmunodeficiency syndromeHigh prevalenceVirus infectionHigh riskGeneral populationElevated incidenceDrug usePrison inmatesTesting treatmentsHealth careAIDSState prison systemInfectionTreatmentMore research
1991
Self-Report Interview Data for a Study of HIV-1 Infection among Intravenous Drug Users: Description of Methods and Preliminary Evidence on Validity
Anthony J, Vlahov D, Celentano D, Menon A, Margolick J, Cohn S, Nelson K, Polk B. Self-Report Interview Data for a Study of HIV-1 Infection among Intravenous Drug Users: Description of Methods and Preliminary Evidence on Validity. Journal Of Drug Issues 1991, 21: 739-757. DOI: 10.1177/002204269102100405.Peer-Reviewed Original ResearchIntravenous drug usersHIV-1 infectionDrug usersDrug useT lymphocyte cell subsetsActive intravenous drug usersSelf-report interview dataHIV-1 serostatusOnset of AIDSPreliminary evidenceCell subsetsDrug injectionBaseline interviewStudy populationCommunity outreach effortsPrior treatmentDrug dependencePhysical stigmataInfectionSelf-reported dataBaltimore CityYear historyInjection equipmentAIDSBaseline