2001
Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men
Sterling T, Vlahov D, Astemborski J, Hoover D, Margolick J, Quinn T. Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men. New England Journal Of Medicine 2001, 344: 720-725. PMID: 11236775, DOI: 10.1056/nejm200103083441003.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsCD4 Lymphocyte CountDisease ProgressionDisease-Free SurvivalEligibility DeterminationFemaleHIV AntibodiesHIV InfectionsHIV-1HumansLongitudinal StudiesMalePractice Guidelines as TopicRegression AnalysisReverse Transcriptase Polymerase Chain ReactionRiskRNA, ViralSex FactorsViral LoadConceptsInitial viral loadMedian initial viral loadHIV-1 RNAViral loadLymphocyte countHuman immunodeficiency virus type 1 (HIV-1) infectionPlasma HIV-1 RNA levelsHIV-1 RNA levelsHIV-1 RNA copiesFemale injection drug usersVirus type 1 infectionHIV-1 seroconversionMedian initial CD4Risk of progressionHIV-1 infectionType 1 infectionInjection drug usersLikelihood of progressionRate of progressionAntiretroviral therapyInitial CD4Hazard ratioAntiretroviral treatmentTreatment guidelinesImmunodeficiency syndrome
1997
The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users
Lyles C, Margolick J, Astemborski J, Graham N, Anthony J, Hoover D, Vlahov D. The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users. AIDS 1997, 11: 1255-1262. PMID: 9256944, DOI: 10.1097/00002030-199710000-00009.Peer-Reviewed Original ResearchConceptsRate of CD4Lymphocyte countLymphocyte declineDrug use patternsDrug usersRate of declineDrug useMedian initial CD4Episodes of withdrawalSpecific drug typesDrug use variablesDrug use practicesPrevious CD4Initial CD4Mean changeOutcome measuresCD4Animal studiesDrug AdministrationEast BaltimoreDrug typeCells xLymphocytesInjection frequencyOutreach techniques