2005
Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women
Dancheck B, Tang A, Thomas A, Smit E, Vlahov D, Semba R. Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 198-201. PMID: 16186738, DOI: 10.1097/01.qai.0000165909.12333.07.Peer-Reviewed Original ResearchConceptsInjection drug useIron deficiency anemiaHepatitis C virus statusFemale injection drug usersC virus statusInjection drug usersDeficiency anemiaDrug useIron deficiencyRisk factorsVirus statusDrug usersMultivariate analysisInjection drug use historyCD4 lymphocyte countHIV-seronegative womenIndependent risk factorHIV-positive womenCross-sectional studyFurther longitudinal studiesNatural history studiesIntravenous Experience (ALIVE) studyDrug use historyHIV-seropositiveLymphocyte count
2002
Prospective study of infective endocarditis among injection drug users
Wilson L, Thomas D, Astemborski J, Freedman T, Vlahov D. Prospective study of infective endocarditis among injection drug users. The Journal Of Infectious Diseases 2002, 185: 1761-1766. PMID: 12085322, DOI: 10.1086/340827.Peer-Reviewed Original ResearchConceptsInjection drug usersInfective endocarditisHIV-seronegative injection drug usersDrug usersHuman immunodeficiency virus (HIV) infectionCohort of IDUsInjection drug use behaviorsCD4 lymphocyte countImmunodeficiency virus infectionCase-control studyDrug use frequencyDrug use behaviorsHIV immunosuppressionLymphocyte countCase patientsHIV statusAlcohol intakeProspective studyInverse associationRisk factorsVirus infectionMultivariate analysisEndocarditisHIVIncidenceRisk factors and cumulative incidence of anaemia among HIV-infected injection drug users
Semba R, Shah N, Vlahov D. Risk factors and cumulative incidence of anaemia among HIV-infected injection drug users. International Journal Of STD & AIDS 2002, 13: 119-123. PMID: 11839167, DOI: 10.1258/0956462021924758.Peer-Reviewed Original ResearchConceptsInjection drug usersCumulative incidenceRisk factorsDrug usersMycobacterium avium complex infectionHigher body mass indexBody mass indexLongitudinal cohort studyZidovudine useCohort studyLymphocyte countOral thrushMass indexComplex infectionFemale genderHigh riskLower riskAnemiaMicrocytic anemiaIncidenceWeight lossCells/Marijuana useRiskCD4
2001
Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study
Ickovics J, Hamburger M, Vlahov D, Schoenbaum E, Schuman P, Boland R, Moore J, Group F. Mortality, CD4 Cell Count Decline, and Depressive Symptoms Among HIV-Seropositive Women: Longitudinal Analysis From the HIV Epidemiology Research Study. JAMA 2001, 285: 1466-1474. PMID: 11255423, DOI: 10.1001/jama.285.11.1466.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusChronic depressive symptomsCD4 cell countHIV-seropositive womenTreatment of depressionDepressive symptomsCell countDisease progressionBaseline CD4 cell countCD4 cell count declineHIV Epidemiologic Research StudyCell count declineCD4 lymphocyte countBaseline viral loadEpidemiologic Studies Depression ScaleHIV disease progressionHIV Epidemiology Research StudyLongitudinal cohort studyEpidemiologic research studiesImpact of depressionAcademic medical centerSelf-reported CenterCohort studyLymphocyte countCount declineInitial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men
Sterling T, Vlahov D, Astemborski J, Hoover D, Margolick J, Quinn T. Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men. New England Journal Of Medicine 2001, 344: 720-725. PMID: 11236775, DOI: 10.1056/nejm200103083441003.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsCD4 Lymphocyte CountDisease ProgressionDisease-Free SurvivalEligibility DeterminationFemaleHIV AntibodiesHIV InfectionsHIV-1HumansLongitudinal StudiesMalePractice Guidelines as TopicRegression AnalysisReverse Transcriptase Polymerase Chain ReactionRiskRNA, ViralSex FactorsViral LoadConceptsInitial viral loadMedian initial viral loadHIV-1 RNAViral loadLymphocyte countHuman immunodeficiency virus type 1 (HIV-1) infectionPlasma HIV-1 RNA levelsHIV-1 RNA levelsHIV-1 RNA copiesFemale injection drug usersVirus type 1 infectionHIV-1 seroconversionMedian initial CD4Risk of progressionHIV-1 infectionType 1 infectionInjection drug usersLikelihood of progressionRate of progressionAntiretroviral therapyInitial CD4Hazard ratioAntiretroviral treatmentTreatment guidelinesImmunodeficiency syndrome
1999
The effect of immunodeficiency on cutaneous delayed-type hypersensitivity testing in HIV-infected women without anergy: implications for tuberculin testing. HER Study Group. HIV Epidemiology Research.
Klein R, Flanigan T, Schuman P, Smith D, Vlahov D. The effect of immunodeficiency on cutaneous delayed-type hypersensitivity testing in HIV-infected women without anergy: implications for tuberculin testing. HER Study Group. HIV Epidemiology Research. The International Journal Of Tuberculosis And Lung Disease 1999, 3: 681-8. PMID: 10460100.Peer-Reviewed Original ResearchConceptsCell countSeronegative womenHigh-risk seronegative womenHuman immunodeficiency virus (HIV) infectionDelayed-type hypersensitivity testingDegree of immunodeficiencyHIV antibody testingImmunodeficiency virus infectionType hypersensitivity responseEffects of immunodeficiencyUrban medical centerDTH antigensDTH testingHIV seropositivesHIV-seronegativesPPD sizeSeropositive womenLymphocyte countHIV infectionAntibody testingHypersensitivity responseTuberculin antigenCutaneous responseHypersensitivity testingTetanus toxoid
1998
Vitamin A Supplementation and Human Immunodeficiency Virus Load in Injection Drug Users
Semba R, Lyles C, Margolick J, Caiaffa W, Farzadegan H, Cohn S, Vlahov D. Vitamin A Supplementation and Human Immunodeficiency Virus Load in Injection Drug Users. The Journal Of Infectious Diseases 1998, 177: 611-616. PMID: 9498439, DOI: 10.1086/514235.Peer-Reviewed Original ResearchConceptsCD4 lymphocyte countHigh-dose vitaminHIV loadInjection drug usersLymphocyte countDrug usersVitamin AHuman immunodeficiency virus (HIV) infectionPlacebo-controlled clinical trialHuman immunodeficiency virus loadImmunodeficiency virus infectionUse of vitaminsPlasma vitaminHIV replicationVirus loadClinical trialsVirus infectionClinical investigationRetinol equivalentsSupplementationRetinoic acid response elementVitaminWeeksAcid response elementCount
1997
The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users
Lyles C, Margolick J, Astemborski J, Graham N, Anthony J, Hoover D, Vlahov D. The influence of drug use patterns on the rate of CD4+ lymphocyte decline among HIV-1-infected injecting drug users. AIDS 1997, 11: 1255-1262. PMID: 9256944, DOI: 10.1097/00002030-199710000-00009.Peer-Reviewed Original ResearchConceptsRate of CD4Lymphocyte countLymphocyte declineDrug use patternsDrug usersRate of declineDrug useMedian initial CD4Episodes of withdrawalSpecific drug typesDrug use variablesDrug use practicesPrevious CD4Initial CD4Mean changeOutcome measuresCD4Animal studiesDrug AdministrationEast BaltimoreDrug typeCells xLymphocytesInjection frequencyOutreach techniques
1994
Drug smoking, Pneumocystis carinii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users.
Caiaffa W, Vlahov D, Graham N, Astemborski J, Solomon L, Nelson K, Muñoz A. Drug smoking, Pneumocystis carinii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users. American Journal Of Respiratory And Critical Care Medicine 1994, 150: 1493-1498. PMID: 7952605, DOI: 10.1164/ajrccm.150.6.7952605.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsCocaineCohort StudiesCrack CocaineFemaleHIV SeronegativityHIV SeropositivityHIV-1HumansImmunocompromised HostIncidenceMaleMarijuana SmokingOdds RatioPneumoniaPneumonia, PneumocystisRisk FactorsSmokingSubstance Abuse, IntravenousSubstance-Related DisordersConceptsInjection drug usersPneumocystis carinii pneumoniaHIV-seropositive injection drug usersBacterial pneumoniaOdds ratioCarinii pneumoniaCigarette smokingFirst episodeDrug usersIllicit drugsSeropositive injection drug usersCD4 lymphocyte countHIV-seronegative subjectsMedical record reviewHuman immunodeficiency virusCells/Conditional logistic regressionSeronegative subjectsCohort studyLymphocyte countRecord reviewImmunodeficiency virusControl subjectsRisk factorsUnivariate analysisComparison of clinical manifestations of HIV infection between male and female injecting drug users
Vlahov D, Muñoz A, Solomon L, Astemborski J, Lindsay A, Anderson J, Galai N, Nelson K. Comparison of clinical manifestations of HIV infection between male and female injecting drug users. AIDS 1994, 8: 819-824. PMID: 7916193, DOI: 10.1097/00002030-199406000-00015.Peer-Reviewed Original ResearchConceptsCD4 cell countHIV infectionCell countDrug usersMedian CD4 cell countPosterior cervical lymph nodesAIDS-free HIVHIV-seropositive menCervical lymph nodesHIV-seronegative controlsDiagnosis of AIDSShortness of breathPhysical examination findingsHIV-seropositive participantsSymptoms of diarrheaHIV serologyGenital herpesLymphocyte countLymph nodesMedian ageSimilar CD4Examination findingsClinical manifestationsClinical symptomsConstitutional signsDirect Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users
Margolick J, Muñoz A, Vlahov D, Astemborski J, Solomon L, He X, Nelson K, Saah A. Direct Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users. JAMA Internal Medicine 1994, 154: 869-875. PMID: 7908795, DOI: 10.1001/archinte.1994.00420080065006.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-positive homosexual menLymphocyte countHomosexual menImmunodeficiency syndromeDrug usersRate of declineStudy entryClinical outcomesHuman immunodeficiency virus (HIV) infectionDevelopment of thrushMore frequent developmentImmunodeficiency virus infectionT cell subsetsInjecting Drug UsersProgression of diseaseRisk group membershipLower absolute numbersLymphocyte numbersClinical progressionClinical symptomsInitial levelDisease progressionVirus infectionStudy groupCD4
1992
Prevalence of Tuberculin Positivity and Skin Test Anergy in HIV-1—Seropositive and —Seronegative Intravenous Drug Users
Graham N, Nelson K, Solomon L, Bonds M, Rizzo R, Scavotto J, Astemborski J, Vlahov D. Prevalence of Tuberculin Positivity and Skin Test Anergy in HIV-1—Seropositive and —Seronegative Intravenous Drug Users. JAMA 1992, 267: 369-373. PMID: 1727959, DOI: 10.1001/jama.1992.03480030047035.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHIV-1 seropositivesSkin test anergyHIV-1 seropositive groupSeronegative intravenous drug usersTuberculin positivityLymphocyte countPPD positivityHIV-1-seropositive intravenous drug usersPPD tuberculinDrug usersHuman immunodeficiency virus serostatusSeropositive intravenous drug usersHIV-1 seropositive patientsTuberculin skin test resultsHIV-1 seronegativeHIV-1 seronegativesPPD test resultsHIV-1 seropositivityDelayed-type hypersensitivityCommunity-based cohortSkin test resultsYears of agePositive test resultsInverse linear trend