2007
Identifying injection drug users at risk of nonfatal overdose.
Coffin P, Tracy M, Bucciarelli A, Ompad D, Vlahov D, Galea S. Identifying injection drug users at risk of nonfatal overdose. Academic Emergency Medicine 2007, 14: 616-23. PMID: 17554010, DOI: 10.1197/j.aem.2007.04.005.Peer-Reviewed Original ResearchConceptsDrug usersHabitual drug usersNonfatal overdoseAggressive prevention effortsAgonist maintenance treatmentSerious withdrawal symptomsInjection drug usersFurther longitudinal studiesIndividual-level risk factorsTake-home naloxoneOverdose prevention interventionsFuture overdosesMaintenance treatmentWithdrawal symptomsRisk factorsDrug overdoseRecent overdoseEmergency physiciansOverdose riskPrevention interventionsHigh riskOverdoseMedical careYounger ageU.S. adultsEarly immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users
Mehta S, Lucas G, Astemborski J, Kirk G, Vlahov D, Galai N. Early immunologic and virologic responses to highly active antiretroviral therapy and subsequent disease progression among HIV-infected injection drug users. AIDS Care 2007, 19: 637-645. PMID: 17505924, DOI: 10.1080/09540120701235644.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyRisk of progressionVirologic responseTreatment interruptionImmunologic responseAntiretroviral therapyCommunity-based injection drug usersDrug usersMultiple Cox regression analysisRecent outpatient visitYears of HAARTCox regression analysisInjection drug useNew AIDS diagnosesSubsequent disease progressionEarly responseHAART initiationHAART initiatorsHIV careOutpatient visitsCox regressionPrognostic valueAIDS diagnosisPoor response
2006
Physical activity in a cohort of HIV-positive and HIV-negative injection drug users
Smit E, Crespo C, Semba R, Jaworowicz D, Vlahov D, Ricketts E, Ramirez-Marrero F, Tang A. Physical activity in a cohort of HIV-positive and HIV-negative injection drug users. AIDS Care 2006, 18: 1040-1045. PMID: 17012097, DOI: 10.1080/09540120600580926.Peer-Reviewed Original ResearchConceptsInjection drug usersHIV-positive participantsHIV-positive injection drug usersInjection drug useHIV-negativeVigorous activityPhysical activityDrug usersDrug usePaffenbarger Physical Activity QuestionnaireRecent injection drug usersHIV-negative injection drug usersIntravenous Experience cohortActive antiretroviral therapyCohort of HIVHIV-negative participantsPhysical Activity QuestionnairePhysical activity levelsAntiretroviral therapyHIV infectionViral loadHIV treatmentActivity QuestionnaireAnthropometric measurementsEnergy expenditureThe Nonimpact of the Expanded Syringe Access Program upon Heroin Use, Injection Behaviours, and Crime Indicators in New York City and State
Johnson B, Golub A, Deren S, Jarlais D, Fuller C, Vlahov D. The Nonimpact of the Expanded Syringe Access Program upon Heroin Use, Injection Behaviours, and Crime Indicators in New York City and State. Justice Research And Policy 2006, 8: 27-49. DOI: 10.3818/jrp.8.1.2006.27.Peer-Reviewed Original ResearchSyringe access programsHeroin useDrug usersAccess programInjection drug usersBlood-borne diseasesHealth care providersIllicit drug usersExpanded Syringe Access ProgramHepatitis C.Drug injectionDrug treatmentCare providersClean syringesSyringe accessSubstance abuseNew York StateLarger evaluationSyringesInjection behaviorNew York CityHIVYork CityDisease
2005
Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women
Dancheck B, Tang A, Thomas A, Smit E, Vlahov D, Semba R. Injection Drug Use Is an Independent Risk Factor for Iron Deficiency and Iron Deficiency Anemia Among HIV-Seropositive and HIV-Seronegative Women. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 40: 198-201. PMID: 16186738, DOI: 10.1097/01.qai.0000165909.12333.07.Peer-Reviewed Original ResearchConceptsInjection drug useIron deficiency anemiaHepatitis C virus statusFemale injection drug usersC virus statusInjection drug usersDeficiency anemiaDrug useIron deficiencyRisk factorsVirus statusDrug usersMultivariate analysisInjection drug use historyCD4 lymphocyte countHIV-seronegative womenIndependent risk factorHIV-positive womenCross-sectional studyFurther longitudinal studiesNatural history studiesIntravenous Experience (ALIVE) studyDrug use historyHIV-seropositiveLymphocyte countLiver enzyme values in injection drug users with chronic hepatitis C
Mehta S, Netski D, Sulkowski M, Strathdee S, Vlahov D, Thomas D. Liver enzyme values in injection drug users with chronic hepatitis C. Digestive And Liver Disease 2005, 37: 674-680. PMID: 15951255, DOI: 10.1016/j.dld.2005.03.009.Peer-Reviewed Original ResearchConceptsHepatitis C virusHepatitis C virus-infected personsAcute viral hepatitisLiver enzyme valuesVirus-infected personsC virusAminotransferase levelsViral hepatitisAlanine aminotransferaseAlanine aminotransferase/aspartate aminotransferase ratioChronic hepatitis C virus (HCV) infectionEnzyme valuesHepatitis C virus infectionAspartate aminotransferase ratioC virus infectionChronic hepatitis CHigher alanine aminotransferaseInjection drug usersHepatitis CAminotransferase ratioSerologic testingLiver enzymesULNVirus infectionDrug usersSexual Risk Behavior Among Injection Drug Users Before Widespread Availability of Highly Active Antiretroviral Therapy
Rusch M, Farzadegan H, Tarwater P, Safaeian M, Vlahov D, Strathdee S. Sexual Risk Behavior Among Injection Drug Users Before Widespread Availability of Highly Active Antiretroviral Therapy. AIDS And Behavior 2005, 9: 289-299. PMID: 16133905, DOI: 10.1007/s10461-005-9003-4.Peer-Reviewed Original ResearchConceptsInjection drug usersCondom useAntiretroviral therapyHIV testingDrug usersEligible injection drug usersRisk behaviorsActive antiretroviral therapyInconsistent condom useSexual risk behaviorsIDU cohortHIV transmissionRetrospective analysisLower riskStudy exposureSexual riskLong-term studiesTherapySignificant changesCounselingRiskExposureLogistic modelWidespread availabilityCohort556-S: Factors Associated with the use of ‘Street Methadone’ by HIV-Seropositive Injection Drug users in Four Us Cities
Gern R, Eldred L, Gourevitch M, Metsch L, Latkin C, Gomez C, Vlahov D. 556-S: Factors Associated with the use of ‘Street Methadone’ by HIV-Seropositive Injection Drug users in Four Us Cities. American Journal Of Epidemiology 2005, 161: s139-s139. DOI: 10.1093/aje/161.supplement_1.s139c.Peer-Reviewed Original Research
2004
Comparison of HIV infection risk behaviors among injection drug users from East and West Coast US cities
Garfein R, Monterroso E, Tong T, Vlahov D, Des Jarlais D, Selwyn P, Kerndt P, Word C, Fernando M, Ouellet L, Holmberg S. Comparison of HIV infection risk behaviors among injection drug users from East and West Coast US cities. Journal Of Urban Health 2004, 81: 260-267. PMID: 15136659, PMCID: PMC3456450, DOI: 10.1093/jurban/jth112.Peer-Reviewed Original ResearchConceptsInjection drug usersRisk behaviorsHIV seroprevalenceHigh human immunodeficiency virus (HIV) seroprevalenceDrug usersHIV infection risk behaviorsHuman immunodeficiency virus (HIV) seroprevalenceInfection risk behaviorsPotential risk factorsHIV risk behaviorsHIV incidenceHIV statusRisk factorsVirus seroprevalenceSexual partnersPrevention effortsSeroprevalenceBaseline dataHIVFace interviewsInjectionNew York CityFurther effortsNew HavenParticipantsIncrease in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users
Tun W, Gange S, Vlahov D, Strathdee S, Celentano D. Increase in Sexual Risk Behavior Associated with Immunologic Response to Highly Active Antiretroviral Therapy among HIV-Infected Injection Drug Users. Clinical Infectious Diseases 2004, 38: 1167-1174. PMID: 15095224, DOI: 10.1086/383033.Peer-Reviewed Original ResearchConceptsInjection drug usersActive antiretroviral therapyHAART initiationCell countAntiretroviral therapyDrug usersSexual intercourseRisk reduction counselingHuman immunodeficiency virusLarge cohort studyDrug injection behaviorInjection of drugsUnprotected sexual intercourseSemiannual visitsReduction counselingCohort studyHIV infectionHIV serostatusImmunodeficiency virusImmunologic responseNeedle sharingBlood samplesSurvival analysisRisk behaviorsCD4Hepatitis C incidence—a comparison between injection and noninjection drug users in New York City
Fuller C, Ompad D, Galea S, Wu Y, Koblin B, Vlahov D. Hepatitis C incidence—a comparison between injection and noninjection drug users in New York City. Journal Of Urban Health 2004, 81: 20-24. PMID: 15047780, PMCID: PMC3456148, DOI: 10.1093/jurban/jth084.Peer-Reviewed Original ResearchConceptsHepatitis C virusInjection drug usersNoninjection drug usersDrug usersHCV seropositiveRisk of HCVNew injection drug usersPerson-time analysisAnnual incidence rateHepatitis C incidenceAnnual incident rateHigh-risk practicesHCV incidenceHCV seroconvertersNon-IDUsHCV serologyHCV preventionC virusRisk factorsIncidence ratePrevention servicesOnset of injectionEarly preventionNew York CityRisk Survey
2003
Retinoids and Drugs of Abuse: Implications for Neurological Disease Risk in Human Immunodeficiency Virus Type 1 Infection
Royal W, Vlahov D, Lyles C, Gajewski C. Retinoids and Drugs of Abuse: Implications for Neurological Disease Risk in Human Immunodeficiency Virus Type 1 Infection. Clinical Infectious Diseases 2003, 37: s427-s432. PMID: 14648459, DOI: 10.1086/377554.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 (HIV-1) infectionVirus type 1 infectionType 1 infectionDrug usersSeronegative control subjectsRetinoic acidDevelopment of HIVInjection drug usersTumor necrosis factorNervous system diseasesLevels of retinolMononuclear cell lineNeurological disease riskTrans retinoic acidDrugs of abuseRetinoid administrationClinical outcomesRetinol-binding proteinImmunomodulatory effectsControl subjectsNecrosis factorSystem diseasesNeurological diseasesHIVDisease riskLongitudinal Patterns of Drug Injection Behavior in the ALIVE Study Cohort,1988–2000: Description and Determinants
Galai N, Safaeian M, Vlahov D, Bolotin A, Celentano D. Longitudinal Patterns of Drug Injection Behavior in the ALIVE Study Cohort,1988–2000: Description and Determinants. American Journal Of Epidemiology 2003, 158: 695-704. PMID: 14507606, DOI: 10.1093/aje/kwg209.Peer-Reviewed Original ResearchConceptsInjection drug usersDrug injection behaviorDrug usersIntravenous Experience (ALIVE) studyDrug treatment programsHistory of incarcerationLogistic regression modelsALIVE studySemiannual visitsMultinomial logistic regression modelsBaseline factorsChronic diseasesDrug injectionRecent overdoseCessation attemptsDrug use transitionsDrug injectorsCommunity outreach effortsLongitudinal patternsHigh mortalityEarly determinantsYounger ageTreatment programInjection behaviorStudy periodSocial Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users
Fuller C, Vlahov D, Latkin C, Ompad D, Celentano D, Strathdee S. Social Circumstances of Initiation of Injection Drug Use and Early Shooting Gallery Attendance: Implications for HIV Intervention Among Adolescent and Young Adult Injection Drug Users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 32: 86. PMID: 12514419, DOI: 10.1097/00126334-200301010-00013.Peer-Reviewed Original ResearchConceptsInjection drug usersNew injection drug usersOlder injection drug usersYoung adult injection drug usersDrug usersHigh-risk injection drug usersStreet-recruited injection drug usersAdult injection drug usersYoung injection drug usersGallery attendanceProspective cohort studyInjection drug useMultiple logistic regressionHigh-risk practicesCohort studyMedian ageHIV incidenceHIV prevalenceInnovative intervention strategiesHIV interventionsDrug useLogistic regressionHIVBaseline dataMost participants
2002
Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users?
Kapadia F, Vlahov D, Jarlais D, Strathdee S, Ouellet L, Kerndt P, E E, Williams I, Garfein R. Does Bleach Disinfection of Syringes Protect Against Hepatitis C Infection Among Young Adult Injection Drug Users? Epidemiology 2002, 13: 738-741. PMID: 12410020, DOI: 10.1097/00001648-200211000-00023.Peer-Reviewed Original ResearchConceptsInjection drug usersAnti-HCV seroconversionHepatitis C virusDrug usersOdds ratioBleach useYoung adult injection drug usersSeronegative injection drug usersMajor public health problemAdult injection drug usersBleach disinfectionHepatitis C infectionProspective cohort studyCase-control studyConditional logistic regressionPublic health problemCessation of injectionsC infectionHCV infectionCohort studyC virusProtective effectHealth problemsSeroconversionLogistic regressionFactors Associated with HIV Seroprevalence among Participants Enrolling at a Needle Exchange Program
Vertefeuille J, Strathdee S, Huettner S, Brown M, Vlahov D. Factors Associated with HIV Seroprevalence among Participants Enrolling at a Needle Exchange Program. Journal Of Drug Issues 2002, 32: 1125-1138. DOI: 10.1177/002204260203200408.Peer-Reviewed Original ResearchInjection drug usersHIV seroprevalenceHIV-seronegative counterpartsHIV-seropositive individualsHIV risk factorsDaily cocaine injectionsDaily heroin injectionDrug use characteristicsHarms of drugsHIV seropositive statusNeedle exchange programsLogistic regression modelsSpeedball injectionHIV antibodiesHIV infectionHeroin injectionProspective studyRisk factorsCocaine injectionFactors AssociatedDrug usersMultivariate modelProgram entryHIVSeroprevalenceDrug Dependence among Young Recently Initiated Injection Drug Users
Arria A, Fuller C, Strathdee S, Latkin C, Vlahov D. Drug Dependence among Young Recently Initiated Injection Drug Users. Journal Of Drug Issues 2002, 32: 1089-1102. DOI: 10.1177/002204260203200405.Peer-Reviewed Original ResearchInjection drug usersDrug usersDrug dependenceYoung injection drug usersCurrent drug dependenceDSM-IV criteriaDrug treatmentDrug useSignificant associationSociodemographic characteristicsCommunity settingsMeet criteriaDrug abuseNational Household SurveyHeroinCocaineHigher proportionMalesAssociationHousehold surveyPrevalenceProportionProspective study of infective endocarditis among injection drug users
Wilson L, Thomas D, Astemborski J, Freedman T, Vlahov D. Prospective study of infective endocarditis among injection drug users. The Journal Of Infectious Diseases 2002, 185: 1761-1766. PMID: 12085322, DOI: 10.1086/340827.Peer-Reviewed Original ResearchConceptsInjection drug usersInfective endocarditisHIV-seronegative injection drug usersDrug usersHuman immunodeficiency virus (HIV) infectionCohort of IDUsInjection drug use behaviorsCD4 lymphocyte countImmunodeficiency virus infectionCase-control studyDrug use frequencyDrug use behaviorsHIV immunosuppressionLymphocyte countCase patientsHIV statusAlcohol intakeProspective studyInverse associationRisk factorsVirus infectionMultivariate analysisEndocarditisHIVIncidenceHigh-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study
Fuller C, Vlahov D, Ompad D, Shah N, Arria A, Strathdee S. High-risk behaviors associated with transition from illicit non-injection to injection drug use among adolescent and young adult drug users: a case-control study. Drug And Alcohol Dependence 2002, 66: 189-198. PMID: 11906806, DOI: 10.1016/s0376-8716(01)00200-9.Peer-Reviewed Original ResearchConceptsInjection drug usersInjection drug useAge-matched case-control analysisDrug usersDrug useBlood-borne infectionsAge-matched personsCase-control studyConditional logistic regressionCase-control analysisHigh-risk behaviorsNon-injection heroinCharacteristics of personsHIV seroprevalenceCohort studyInjection useAdult drug usersLogistic regressionPrevention effortsSame calendar timeYoung adult drug usersCalendar timePrior yearAfrican AmericansBaselineHigh Prevalence of Iron Deficiency and Anemia Among Female Injection Drug Users With and Without HIV Infection.
Semba R, Shah N, Strathdee S, Vlahov D. High Prevalence of Iron Deficiency and Anemia Among Female Injection Drug Users With and Without HIV Infection. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 29: 142. PMID: 11832682, DOI: 10.1097/00042560-200202010-00005.Peer-Reviewed Original ResearchConceptsFemale injection drug usersInjection drug usersIron deficiency anemiaHIV infectionDeficiency anemiaIron deficiencyIron supplementationDrug usersHigh mortalityHepatitis C virus infectionC virus infectionHIV-negative womenHepatitis C infectionPrevalence of anemiaHepatitis C virusCross-sectional studyProgression of diseaseC infectionPlasma ferritinC virusOverall prevalenceHigh prevalenceVirus infectionAnemia patientsAnemia