2001
Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS
Gao X, Nelson G, Karacki P, Martin M, Phair J, Kaslow R, Goedert J, Buchbinder S, Hoots K, Vlahov D, O'Brien S, Carrington M. Effect of a Single Amino Acid Change in MHC Class I Molecules on the Rate of Progression to AIDS. New England Journal Of Medicine 2001, 344: 1668-1675. PMID: 11386265, DOI: 10.1056/nejm200105313442203.Peer-Reviewed Original ResearchConceptsRate of progressionHIV-1 infectionClass IHuman immunodeficiency virus type 1 (HIV-1) infectionDifferent peptide-binding specificitiesVirus type 1 infectionRisk of progressionT lymphocyte responsesInfluence of HLAType 1 infectionHIV-1 epitopesSubtypes of HLAHLA class IPeptide-binding specificityMHC class I moleculesAmino acid changesComplex class ISingle amino acid changeClass I moleculesReactive HLAImmunodeficiency syndromeRelated HLAPx groupCommon HLAHIV-1Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men
Sterling T, Vlahov D, Astemborski J, Hoover D, Margolick J, Quinn T. Initial Plasma HIV-1 RNA Levels and Progression to AIDS in Women and Men. New England Journal Of Medicine 2001, 344: 720-725. PMID: 11236775, DOI: 10.1056/nejm200103083441003.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnti-HIV AgentsCD4 Lymphocyte CountDisease ProgressionDisease-Free SurvivalEligibility DeterminationFemaleHIV AntibodiesHIV InfectionsHIV-1HumansLongitudinal StudiesMalePractice Guidelines as TopicRegression AnalysisReverse Transcriptase Polymerase Chain ReactionRiskRNA, ViralSex FactorsViral LoadConceptsInitial viral loadMedian initial viral loadHIV-1 RNAViral loadLymphocyte countHuman immunodeficiency virus type 1 (HIV-1) infectionPlasma HIV-1 RNA levelsHIV-1 RNA levelsHIV-1 RNA copiesFemale injection drug usersVirus type 1 infectionHIV-1 seroconversionMedian initial CD4Risk of progressionHIV-1 infectionType 1 infectionInjection drug usersLikelihood of progressionRate of progressionAntiretroviral therapyInitial CD4Hazard ratioAntiretroviral treatmentTreatment guidelinesImmunodeficiency syndrome
1998
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin M, Dean M, Smith M, Winkler C, Gerrard B, Michael N, Lee B, Doms R, Margolick J, Buchbinder S, Goedert J, O'Brien T, Hilgartner M, Vlahov D, O'Brien S, Carrington M. Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5. Science 1998, 282: 1907-1911. PMID: 9836644, DOI: 10.1126/science.282.5395.1907.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAllelesChemokine CXCL12Chemokines, CXCCohort StudiesDisease ProgressionGenes, DominantGenes, RecessiveGenetic Predisposition to DiseaseGenotypeHaplotypesHeterozygoteHIV InfectionsHIV-1HomozygoteHumansPromoter Regions, GeneticProportional Hazards ModelsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CytokineRisk FactorsSurvival RateConceptsAIDS progressionCell-surface chemokine receptor moleculeCCR5 regulatory regionsChemokine receptor moleculesPercent of patientsAIDS disease progressionHIV-1 infectionCohort of peopleMacrophage-tropic strainsAIDS restriction genesDistinct regulatory influencesCCR2-64IPrincipal coreceptorImmunodeficiency syndromeCCR5-Delta32Genetic epidemiologic analysisDisease progressionHuman immunodeficiencySDF1-3'APromoter genotypeCCR5 geneInfected individualsEpidemiologic analysisHost factorsProgressionThe role of needle exchange programs in HIV prevention.
Vlahov D, Junge B. The role of needle exchange programs in HIV prevention. Public Health Reports 1998, 113 Suppl 1: 75-80. PMID: 9722812, PMCID: PMC1307729.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusNeedle exchange programsCase-control studyNeedle exchangeHIV preventionMultiperson useNew Haven's needle exchange programDrug usersDrug useBlood-borne viral infectionsHepatitis C virus infectionSyringe-sharing behaviorsC virus infectionBlood-borne infectionsInjection drug useBlood-borne pathogensPossession of syringesSyringe trackingHCV infectionHepatitis BHIV seroincidenceHIV infectionImmunodeficiency syndromeHIV transmissionImmunodeficiency virusGenetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant
Winkler C, Modi W, Smith M, Nelson G, Wu X, Carrington M, Dean M, Honjo T, Tashiro K, Yabe D, Buchbinder S, Vittinghoff E, Goedert J, O'Brien T, Jacobson L, Detels R, Donfield S, Willoughby A, Gomperts E, Vlahov D, Phair J, Study A, Study H, Study M, Study M, Cohort S, O'Brien S. Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant. Science 1998, 279: 389-393. PMID: 9430590, DOI: 10.1126/science.279.5349.389.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChemokine CXCL12ChemokinesChemokines, CXCCohort StudiesDisease ProgressionGenesGenetic VariationGenotypeHeterozygoteHIV InfectionsHIV-1HumansMaleMolecular Sequence DataOdds RatioPolymorphism, GeneticRacial GroupsReceptors, CCR2Receptors, CCR5Receptors, ChemokineReceptors, CXCR4Survival AnalysisT-LymphocytesConceptsSDF1-3'AGenetic restrictionRecessive protective effectOnset of AIDSAIDS Cohort StudyStromal-derived factorCohort studyImmunodeficiency syndromeAIDS pathogenesisHuman immunodeficiencyHIV-1Protective effectCommon polymorphismsReceptor variantsGene variantsPrincipal ligandAIDSHomozygous stateGenetic association analysisOnsetCD4CCR5PatientsGene transcriptsImmunodeficiency
1997
Postcoital Vaginal Bleeding as a Risk Factor for Transmission of the Human Immunodeficiency Virus in a Heterosexual Partner Study in Brazil
Guimarães M, Vlahov D, Castilho E. Postcoital Vaginal Bleeding as a Risk Factor for Transmission of the Human Immunodeficiency Virus in a Heterosexual Partner Study in Brazil. JAMA Internal Medicine 1997, 157: 1362-1368. PMID: 9201011, DOI: 10.1001/archinte.1997.00440330102012.Peer-Reviewed Original ResearchConceptsPostcoital vaginal bleedingHIV infectionVaginal bleedingRisk factorsAnal sexMale partnersPostcoital bleedingFemale partnersCondom useHuman immunodeficiency virus (HIV) transmissionSexual contactAdvanced HIV infectionHuman immunodeficiency virusInconsistent condom useHIV positivityAIDS CenterHIV serostatusImmunodeficiency syndromeImmunodeficiency virusHeterosexual contactBleedingEligibility criteriaVaginal sexPartner studiesInfection
1996
Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md
Comer J, Flynn C, Regnery R, Vlahov D, Childs J. Antibodies to Bartonella Species in Inner-city Intravenous Drug Users in Baltimore, Md. JAMA Internal Medicine 1996, 156: 2491-2495. PMID: 8944742, DOI: 10.1001/archinte.1996.00440200111014.Peer-Reviewed Original ResearchConceptsIntravenous drug usersHuman immunodeficiency virus statusB quintanaRisk factorsDrug usersB henselaeDrug useVirus statusHuman immunodeficiency virus-seropositive individualsHuman immunodeficiency virus (HIV) infectionSerum samplesImmunodeficiency virus infectionAvailable serum samplesSignificant risk factorsBehavioral risk factorsPossible risk factorsSignificant inverse associationIndirect immunofluorescent antibodyFrequency of injectionsUrban transmission cyclesBartonella speciesBartonella organismsMode of transmissionCurrent natural historyImmunodeficiency syndrome
1995
Temporal Trends of Incident Human Immunodeficiency Virus Infection in a Cohort of Injecting Drug Users in Baltimore, Md
Nelson K, Vlahov D, Solomon L, Cohn S, Muñoz A. Temporal Trends of Incident Human Immunodeficiency Virus Infection in a Cohort of Injecting Drug Users in Baltimore, Md. JAMA Internal Medicine 1995, 155: 1305-1311. PMID: 7778962, DOI: 10.1001/archinte.1995.00430120091011.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionHuman immunodeficiency virusDrug usersVirus infectionImmunodeficiency virusEffective human immunodeficiency virus (HIV) vaccineHuman immunodeficiency virus risk factorsIncident human immunodeficiency virus (HIV) infectionsHuman immunodeficiency virus (HIV) seroconversionHuman immunodeficiency virus (HIV) antibodyHuman immunodeficiency virus (HIV) vaccinesIllicit drug injectionInjecting Drug UsersHigh-risk populationImmunodeficiency virus vaccinesIncidence of infectionPrevention of infectionSterile injection equipmentEnzyme-linked immunosorbent assaySeronegative participantsStudy clinicAnnual incidenceImmunodeficiency syndromeOverall incidence
1994
Correlates of attitudes concerning human immunodeficiency virus and acquired immunodeficiency syndrome among hospital workers
Gershon R, Curbow B, Kelen G, Celantano D, Lears K, Vlahov D. Correlates of attitudes concerning human immunodeficiency virus and acquired immunodeficiency syndrome among hospital workers. American Journal Of Infection Control 1994, 22: 293-299. PMID: 7847636, DOI: 10.1016/0196-6553(94)90016-7.Peer-Reviewed Original ResearchConceptsHigher knowledge scoresMode of transmissionGeneral AIDS knowledgeHospital workersKnowledge scoreOccupational riskAIDS knowledgeClinical workersHuman immunodeficiency virusCross-sectional studyInner-city hospitalHIV infectionImmunodeficiency syndromeAcute careImmunodeficiency virusModifiable factorsNonclinical workersHigher scoresResponse rateCorrelates of attitudesHIVAIDSLow levelsHospital employeesScoresDirect Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users
Margolick J, Muñoz A, Vlahov D, Astemborski J, Solomon L, He X, Nelson K, Saah A. Direct Comparison of the Relationship Between Clinical Outcome and Change in CD4+ Lymphocytes in Human Immunodeficiency Virus—Positive Homosexual Men and Injecting Drug Users. JAMA Internal Medicine 1994, 154: 869-875. PMID: 7908795, DOI: 10.1001/archinte.1994.00420080065006.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-positive homosexual menLymphocyte countHomosexual menImmunodeficiency syndromeDrug usersRate of declineStudy entryClinical outcomesHuman immunodeficiency virus (HIV) infectionDevelopment of thrushMore frequent developmentImmunodeficiency virus infectionT cell subsetsInjecting Drug UsersProgression of diseaseRisk group membershipLower absolute numbersLymphocyte numbersClinical progressionClinical symptomsInitial levelDisease progressionVirus infectionStudy groupCD4Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users
Alcabes P, Muñoz A, Vlahov D, Friedland G. Maturity of human immunodeficiency virus infection and incubation period of acquired immunodeficiency syndrome in injecting drug users. Annals Of Epidemiology 1994, 4: 17-26. PMID: 7911376, DOI: 10.1016/1047-2797(94)90038-8.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeBaltimoreCD4-Positive T-LymphocytesCohort StudiesConfidence IntervalsHIV InfectionsHIV SeroprevalenceHomosexualityHumansIncidenceLeukocyte CountLife TablesMaleModels, StatisticalNew York CityPlatelet CountRegression AnalysisSubstance Abuse, IntravenousSurvival RateTime FactorsConceptsHIV infectionDrug usersImmunodeficiency syndromeMedian timeCombined cohortHomosexual menHuman immunodeficiency virus (HIV) infectionHuman immunodeficiency virus (HIV) epidemicPercent of CD4Immunodeficiency virus infectionIncident HIV infectionProduct-limit methodMarkers of maturityHIV incubation distributionsPlatelet countVirus infectionLarge cohortSeroconversionCohortInfectionConfidence intervalsIncubation distributionAIDSVirus epidemicPopulation groups
1993
Bacterial Pneumonia in Adult Populations with Human Immunodeficiency Virus (HIV) Infection
Caiaffa W, Graham N, Vlahov D. Bacterial Pneumonia in Adult Populations with Human Immunodeficiency Virus (HIV) Infection. American Journal Of Epidemiology 1993, 138: 909-922. PMID: 8256779, DOI: 10.1093/oxfordjournals.aje.a116812.Peer-Reviewed Original ResearchConceptsBacterial pneumoniaRisk factorsHuman immunodeficiency virus (HIV) infectionEffectiveness of chemoprophylaxisImmunodeficiency virus infectionRecurrent bacterial pneumoniaHuman immunodeficiency virusEfficacy of interventionsPneumonia ratesImmunodeficiency syndromeImmunodeficiency virusClinical trialsVaccine interventionsVirus infectionEpidemiologic studiesClinical practicePneumoniaAdult populationDiagnostic algorithmFuture interventionsInterventionHIVSuch interventionsPopulationChemoprophylaxisFrequency of left ventricular dysfunction and other echocardiographic abnormalities in human immunodeficiency virus seronegative intravenous drug users
Willoughby S, Vlahov D, Herskowitz A. Frequency of left ventricular dysfunction and other echocardiographic abnormalities in human immunodeficiency virus seronegative intravenous drug users. The American Journal Of Cardiology 1993, 71: 446-447. PMID: 8430637, DOI: 10.1016/0002-9149(93)90451-h.Peer-Reviewed Original ResearchConceptsIntravenous drug usersSeronegative intravenous drug usersIllicit drug useDrug usersDrug useLeft ventricularHIV-seronegative intravenous drug usersHuman immunodeficiency virus (HIV) infectionHIV-seropositive patientsNormal coronary arteriesImmunodeficiency virus infectionLeft ventricular dysfunctionLV ejection fractionGlobal left ventricularDevelopment of cardiomyopathyEchocardiographic abnormalitiesEchocardiographic findingsLV dysfunctionSeropositive patientsVentricular dysfunctionEjection fractionHIV infectionRetrospective reviewImmunodeficiency syndromeCoronary angiogram
1992
Effect of Chronic Substance Abuse on the Neuropsychological Performance of Intravenous Drug Users with a High Prevalence of HIV-1 Seropositivity
Concha M, Graham N, Muñoz A, Vlahov D, Royal W, Updike M, Nance-Sproson T, Seines O, McArthur J. Effect of Chronic Substance Abuse on the Neuropsychological Performance of Intravenous Drug Users with a High Prevalence of HIV-1 Seropositivity. American Journal Of Epidemiology 1992, 136: 1338-1348. PMID: 1362630, DOI: 10.1093/oxfordjournals.aje.a116446.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBaltimoreBlack or African AmericanCD4-Positive T-LymphocytesChronic DiseaseCognition DisordersConfounding Factors, EpidemiologicEducational StatusEmploymentEvaluation Studies as TopicFemaleHIV SeropositivityHIV SeroprevalenceHIV-1HumansLeukocyte CountLinear ModelsMaleMass ScreeningNeuropsychological TestsPopulation SurveillancePredictive Value of TestsPrisonsPsychomotor PerformanceSubstance Abuse, IntravenousConceptsNeuropsychological test performanceHIV-1 seropositivityIntravenous drug usersTest performanceNeuropsychological performancePractice effectsHuman immunodeficiency virus type 1 (HIV-1) infectionDrug usersVirus type 1 infectionSubstance abuseSignificant practice effectsHIV-1 serostatusType 1 infectionIntravenous Experience (ALIVE) studyFrequency of drugChronic substance abuseNeuropsychological functioningCognitive performanceImmunodeficiency syndromeAsymptomatic stageHigh prevalenceOutcome measuresDrug useIntoxicated individualsMultivariate analysisHIV INFECTION AND AIDS AMONG U.S. PRISON INMATES
Behrendt C, Vlahov D, Clark J, Kendig N. HIV INFECTION AND AIDS AMONG U.S. PRISON INMATES. Journal Of Crime And Justice 1992, 15: 173-186. DOI: 10.1080/0735648x.1992.9721458.Peer-Reviewed Original ResearchHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionIntravenous drug useVoluntary HIV testingOnset of AIDSCause of deathRisk reduction programsHIV infectionHIV testingHIV-positiveImmunodeficiency syndromeHigh prevalenceVirus infectionHigh riskGeneral populationElevated incidenceDrug usePrison inmatesTesting treatmentsHealth careAIDSState prison systemInfectionTreatmentMore research
1991
The Alive Study: A Longitudinal Study of HIV-1 Infection in Intravenous Drug Users: Description of Methods
Vlahov D, Anthony J, Muñoz A, Margolick J, Nelson K, Celentano D, Solomon L, Polk B. The Alive Study: A Longitudinal Study of HIV-1 Infection in Intravenous Drug Users: Description of Methods. Journal Of Drug Issues 1991, 21: 759-776. DOI: 10.1177/002204269102100406.Peer-Reviewed Original ResearchIntravenous drug usersHuman immunodeficiency virusDrug usersConfidential HIV testingHIV-1 infectionMonths of recruitmentALIVE studyHIV testingImmunodeficiency syndromeImmunodeficiency virusRisk factorsExtensive community outreachLongitudinal studyInfectionCommunity outreachBaltimore MarylandPercentSyndromeCohortRecruitmentProgressionMonths
1990
Occupationally Acquired Human Immunodeficiency Virus-1 Infection in Health Care Workers: A Review
Gershon R, Vlahov D. Occupationally Acquired Human Immunodeficiency Virus-1 Infection in Health Care Workers: A Review. 1990, 131-146. DOI: 10.1007/978-1-4684-5724-7_9.Peer-Reviewed Original ResearchHealth care workersCare workersHuman immunodeficiency virus-1 (HIV-1) infectionHIV-1-positive individualsHuman immunodeficiency virusVirus-1 infectionPublic health servicesHealth care systemImmunodeficiency syndromeImmunodeficiency virusPositive individualsHIV-1Health servicesInfected individualsType 1Care systemYear 20IndividualsSyndromeInfectionAIDS
1989
Immunological effects of HIV-1 infection on the humoral response to malaria in an African population.
Wabwire-Mangen F, Shiff C, Vlahov D, Kline R, Serwadda D, Sewankambo N, Mugerwa R, Quinn T. Immunological effects of HIV-1 infection on the humoral response to malaria in an African population. American Journal Of Tropical Medicine And Hygiene 1989, 41: 504-11. PMID: 2683820, DOI: 10.4269/ajtmh.1989.41.504.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnimalsAntibodies, ProtozoanAntigens, ProtozoanAntigens, SurfaceCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHIV SeropositivityHIV-1HumansMalariaMaleMiddle AgedPlasmodiumPlasmodium falciparumPlasmodium malariaeProtozoan ProteinsUgandaConceptsHIV-1 infectionTrauma patientsClinical AIDSSeronegative patientsAntibody levelsHIV-1HIV-1-seronegative patientsHIV-1 seropositive patientsPolyclonal B cell activationCross-sectional studyHigh malaria transmissionB cell stimulationB cell activationSeropositive patientsImmunodeficiency syndromeMalaria antibodiesHumoral responseImmunological effectsSerological responseStudy groupPatientsCell activationMalaria transmissionControl populationLess antibody