2001
Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data.
Ioannidis J, Rosenberg P, Goedert J, Ashton L, Benfield T, Buchbinder S, Coutinho R, Eugen-Olsen J, Gallart T, Katzenstein T, Kostrikis L, Kuipers H, Louie L, Mallal S, Margolick J, Martinez O, Meyer L, Michael N, Operskalski E, Pantaleo G, Rizzardi G, Schuitemaker H, Sheppard H, Stewart G, Theodorou I, Ullum H, Vicenzi E, Vlahov D, Wilkinson D, Workman C, Zagury J, O'Brien T. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Annals Of Internal Medicine 2001, 135: 782-95. PMID: 11694103, DOI: 10.7326/0003-4819-135-9-200111060-00008.Peer-Reviewed Original ResearchConceptsHIV-1 infectionCCR2-64I alleleHIV-1 RNA levelsHIV-1 disease progressionDevelopment of AIDSIndividual patient dataCCR5-Delta32Decreased riskDisease progressionProtective effectLower HIV-1 RNA levelsRNA levelsProspective cohort studyCase-control studyClear protective effectStrong protective effectChemokine receptor genesRandom-effects modelCCR2-64ICohort studyStudy entryCertain chemokinesAIDSInfectionProgression
1999
Relationship between HIV‐1 viral load and continued drug use in untreated infected injection drug users
CARRIERI M, TAMALET C, VLAHOV D, YAHI N, CHESNEY M, MOATTI J. Relationship between HIV‐1 viral load and continued drug use in untreated infected injection drug users. Addiction Biology 1999, 4: 197-202. PMID: 20575786, DOI: 10.1080/13556219971704.Peer-Reviewed Original ResearchRecent heroin injectionViral loadDrug useHeroin injectionHIV-1 plasma viral loadInfected injection drug usersHIV-1 viral loadHIV viral loadPlasma viral loadDevelopment of AIDSContinued drug useInjection drug usersLong-term progressionSelf-administered questionnaireAntiretroviral treatmentClinical stageClinical examinationMedical recordsOutpatient carePatientsDrug usersSerological assaysHospital departmentsLaboratory informationRisk practices
1992
Prognostic indicators for development of AIDS among intravenous drug users.
Muñoz A, Vlahov D, Solomon L, Margolick J, Bareta J, Cohn S, Astemborski J, Nelson K. Prognostic indicators for development of AIDS among intravenous drug users. JAIDS Journal Of Acquired Immune Deficiency Syndromes 1992, 5: 694-700. PMID: 1613668.Peer-Reviewed Original ResearchConceptsCD4 cell countIntravenous drug usersClinical symptomsDrug usersCell countHigher CD4 cell countsHIV-1-related symptomsSeropositive intravenous drug usersPneumocystis carinii prophylaxisIntravenous drug useDevelopment of AIDSDose-response relationshipYear of enrollmentSerum neopterinLaboratory markersSerum betaPrognostic indicatorClinical evaluationAntiviral agentsRelative hazardDrug useSurvival analysisMultivariate analysisSignificant associationAIDS