2003
Effects of CCR5-Δ32 and CCR2-64I alleles on HIV-1 disease progression
Mulherin S, O'Brien T, Ioannidis J, Goedert J, Buchbinder S, Coutinho R, Jamieson B, Meyer L, Michael N, Pantaleo G, Rizzardi G, Schuitemaker H, Sheppard H, Theodorou I, Vlahov D, Rosenberg P. Effects of CCR5-Δ32 and CCR2-64I alleles on HIV-1 disease progression. AIDS 2003, 17: 377-387. PMID: 12556692, DOI: 10.1097/00002030-200302140-00012.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionHIV-1 seroconvertersCCR5-Delta32CCR2-64ICourse of infectionDisease progressionLower riskChemokine receptor gene polymorphismsCox proportional hazards modelHIV-1 infectionIndividual patient dataCCR2-64I alleleProportional hazards modelReceptor gene polymorphismsCCR2-64I.Disease courseSurvival benefitHazards modelGene polymorphismsCCR5-Δ32Significant protectionAIDSPatient dataInfectionSeroconverters
1999
Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters
Sterling T, Lyles C, Vlahov D, Astemborski J, Margolick J, Quinn T. Sex Differences in Longitudinal Human Immunodeficiency Virus Type 1 RNA Levels among Seroconverters. The Journal Of Infectious Diseases 1999, 180: 666-672. PMID: 10438353, DOI: 10.1086/314967.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus type 1 RNA levelsHIV-1 seroconvertersSex differencesCopies/mLHIV-1 pathogenesisInjection drug usersCase-control studyTime of seroconversionCross-sectional studyCourse of infectionMale patientsRapid progressorsFemale patientsCopies/Drug usersMale controlsVirus levelsPatientsRNA levelsSeroconvertersWomenMenNonprogressorsSeroconversionProgressors
1995
Identification of Human Immunodeficiency Virus Primary Isolates Resistant to Interferon-α and Correlation of Prevalence to Disease Progression
Kiinzi M, Farzadegan H, Margolick J, Vlahov D, Pitha P. Identification of Human Immunodeficiency Virus Primary Isolates Resistant to Interferon-α and Correlation of Prevalence to Disease Progression. The Journal Of Infectious Diseases 1995, 171: 822-828. PMID: 7706808, DOI: 10.1093/infdis/171.4.822.Peer-Reviewed Original ResearchConceptsCD4 cell numbersHIV infectionIFN-alphaLow CD4 cell numbersSerum IFN-alpha levelsHuman immunodeficiency virusIFN-alpha levelsEndogenous IFN-alphaAbsence of AIDSCourse of infectionCell numberCorrelation of prevalenceIFN-alpha 2Immunodeficiency virusDisease progressionPrimary isolatesCell tropismResistant variantsAlpha 2InfectionAIDSPrevalenceFavor survivalSequential analysisIsolates