Inference of Surface Membrane Factors of HIV-1 Infection through Functional Interaction Networks
Jaeger S, Ertaylan G, van Dijk D, Leser U, Sloot P. Inference of Surface Membrane Factors of HIV-1 Infection through Functional Interaction Networks. PLOS ONE 2010, 5: e13139. PMID: 20967291, PMCID: PMC2953485, DOI: 10.1371/journal.pone.0013139.Peer-Reviewed Original ResearchConceptsSurface membrane proteinsMembrane factorsBioinformatics techniquesNovel cell surface proteinCell/tissue typesSurface proteinsFunctional interaction networkDifferent cell/tissue typesSimilar cellular processesCell surface proteinsCellular surface proteinsCellular processesMembrane proteinsInteraction networksFunctional similarityCell typesCommon functionPatient-specific disease progressionDirect interactionProteinSpecific disease progressionTissue typesExcellent targetNetwork centrality analysisComprehensive networkIdentifying potential survival strategies of HIV-1 through virus-host protein interaction networks
van Dijk D, Ertaylan G, Boucher CA, Sloot PM. Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks. BMC Systems Biology 2010, 4: 96. PMID: 20633292, PMCID: PMC2913931, DOI: 10.1186/1752-0509-4-96.Peer-Reviewed Original ResearchConceptsProtein interaction networksHuman protein interaction networkHuman proteinsInteraction networksCellular processesRNA polymerase II transcriptionVirus-host protein interaction networksPolymerase II transcriptionHuman Protein Interaction DatabaseSet of proteinsNetwork motifsPotential survival strategiesVirus-host dynamicsProtein interaction databasesCentral human proteinsVirus-host systemsTranscriptional machineryProteasomal proteinsMotif analysisImportant proteinsNetwork motif analysisInteraction databasesViral strategiesProteinSurvival strategies