2024
An investigation of the role of estradiol in fear reduction during a single session of exposure therapy
Levy H, Mullins J, Tolin D. An investigation of the role of estradiol in fear reduction during a single session of exposure therapy. Cognitive Behaviour Therapy 2024, 53: 364-376. PMID: 38299480, DOI: 10.1080/16506073.2024.2313743.Peer-Reviewed Original ResearchObsessive-compulsive disorderExposure therapyAnxiety disordersPrimary obsessive-compulsive disorderSubjective distress ratingsAnxiety specialty clinicLow estradiol groupFear extinctionSubjective distressFear reductionExposure sessionsBrief delayDistress ratingsRecall delayAnxietyTherapy researchExposure outcomesDisordersSpecialty clinicsHigher estradiolDistressPrimary diagnosisEndogenous estradiolRecallEstradiol group
2022
Mechanisms of Action in Exposure Therapy
Knowles K, Tolin D. Mechanisms of Action in Exposure Therapy. Current Psychiatry Reports 2022, 24: 861-869. PMID: 36399234, DOI: 10.1007/s11920-022-01391-8.Peer-Reviewed Original ResearchConceptsExposure-based interventionsExposure therapyReturn of fearAnxiety-related disordersExtinction learningFear extinctionNeural levelPrefrontal regionsNeurobiological mechanismsSafety behaviorSuch translational researchTherapy workPromising future directionsBehavioral mechanismsPharmacological augmentationMixed resultsBehavioral changesIncreased activationFull symptom reliefMultiple levelsFuture directionsRecent FindingsRecent studiesSymptom improvementMechanism of actionSymptom relief
2021
Low Estradiol May Not Impede Cognitive Restructuring in Women With Anxiety Disorders.
Levy H, Jean A, Ching T, Nett A, Mullins J, Tolin D. Low Estradiol May Not Impede Cognitive Restructuring in Women With Anxiety Disorders. Journal Of Cognitive Psychotherapy 2021, 35: 212-220. PMID: 34362860, DOI: 10.1891/jcpsy-d-20-00038.Peer-Reviewed Original ResearchConceptsCognitive restructuringCognitive reappraisalAnxiety disordersCR taskExtinction-based therapiesSubjective distress ratingsPrimary anxiety disorderSkin conductance responsesLow estradiol groupFear extinctionNegative affectPsychophysiological arousalConductance responsesDistress ratingsCR outcomesCR abilityLow estradiolCR skillsExtinction processPrior researchTaskReappraisalEstradiol groupDisordersAcquisition