2010
A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules
Zhang AX, Murelli RP, Barinka C, Michel J, Cocleaza A, Jorgensen WL, Lubkowski J, Spiegel DA. A Remote Arene-Binding Site on Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules. Journal Of The American Chemical Society 2010, 132: 12711-12716. PMID: 20726553, PMCID: PMC2965167, DOI: 10.1021/ja104591m.Peer-Reviewed Original ResearchMeSH KeywordsAntibodiesAntigen-Antibody ReactionsBinding SitesHumansMaleModels, MolecularMolecular StructureMolecular WeightProstate-Specific AntigenProstatic NeoplasmsSensitivity and Specificity
2009
An Antibody-Recruiting Small Molecule That Targets HIV gp120
Parker CG, Domaoal RA, Anderson KS, Spiegel DA. An Antibody-Recruiting Small Molecule That Targets HIV gp120. Journal Of The American Chemical Society 2009, 131: 16392-16394. PMID: 19839582, PMCID: PMC2783809, DOI: 10.1021/ja9057647.Peer-Reviewed Original ResearchConceptsVirus entryComplement-mediated destructionNew treatment strategiesAntibody-recruiting small moleculeAnti-HIV activityHIV/AIDSViral glycoprotein gp120Env-expressing cellsHuman immune systemHuman T cellsSurface viral glycoproteinsHIV treatmentTreatment strategiesHIV survivalT cellsNovel small moleculesHIV gp120Glycoprotein gp120Immune systemGp120Virus replicationAntibodiesGlobal pandemicViral glycoproteinsVirus particles