2003
In vitro fertilization in the older patient.
Derman SG, Seifer DB. In vitro fertilization in the older patient. Current Women'S Health Reports 2003, 3: 375-83. PMID: 12959695.Peer-Reviewed Original ResearchConceptsOlder patientsClomiphene citrate challenge testBasal follicle-stimulating hormoneAntral follicle countDiminished ovarian reserveLower oocyte yieldFollicle-stimulating hormoneHigher miscarriage rateMüllerian-inhibiting substanceHigher cancellation rateIVF success ratesLower pregnancy ratesFlare protocolInhibin BIVF patientsMiscarriage rateOvarian reserveOvarian volumeFollicle countGnRH antagonistOocyte yieldEstradiol levelsPregnancy rateAgonist doseStimulation protocol
2002
DNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve
Chin KV, Seifer DB, Feng B, Lin Y, Shih WC. DNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve. Fertility And Sterility 2002, 77: 1214-1218. PMID: 12057731, DOI: 10.1016/s0015-0282(02)03114-x.Peer-Reviewed Original ResearchConceptsLuteinized granulosa cellsOvarian reserveDNA microarray analysisGranulosa cellsExpression profilesMicroarray analysisSequence tagsFertilization-embryo transferUniversity-based fertility clinicExpression profilingComplementary DNA microarray analysisGonadotropin stimulationFollicular aspirationMAIN OUTCOMEFertility clinicsWomenDNA microarraysGene expressionCellsGenesProfilingPatientsIVFClinicSignature patterns
1997
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction
Friedman C, Danforth D, Herbosa-Encarnacion C, Arbogast L, Alak B, Seifer D. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertility And Sterility 1997, 68: 607-612. PMID: 9341598, DOI: 10.1016/s0015-0282(97)00278-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCobaltCohort StudiesCorpus LuteumEndothelial Growth FactorsFemaleFollicular FluidGranulosa CellsHumansHypoxiaLymphokinesMaternal AgeMiddle AgedOsmolar ConcentrationOvulation InductionPregnancyPregnancy, High-RiskRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAdvanced reproductive ageVascular endothelial growth factor/vascular permeability factorVascular permeability factorReproductive ageFollicular fluidFactor concentrationsPermeability factorFollicular fluid vascular endothelial growth factor concentrationsGranulosa cellsVascular endothelial growth factor concentrationsYoung womenRetrospective cohort studyReproductive-age womenUniversity Teaching HospitalPg/mLGrowth factor concentrationsCohort studyIVF-ETOvulation inductionHCG administrationAge womenCobalt chlorideTeaching hospitalMAIN OUTCOMEFollicular aspiration