2022
Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
Esencan E, Beroukhim G, Seifer D. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review. Reproductive Biology And Endocrinology 2022, 20: 156. PMID: 36397149, PMCID: PMC9670479, DOI: 10.1186/s12958-022-01033-x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnti-Mullerian HormoneCumulus CellsFemaleFertilityFollicular FluidHumansVascular Endothelial Growth Factor AConceptsInsulin-like growth factor-1Vascular endothelial growth factorAge-related changesAntimullerian hormoneFertility outcomesIndividual studiesGrowth factor-1Endothelial growth factorObstetrical outcomesVitamin DOocyte quantityOvarian agingFollicular depletionFollicular fluidIntraovarian regulatorsRodent studiesHealthy oocytesNarrative reviewReproductive agingPotential modifiersCumulus cellsGrowth factorFactor 1Mitochondrial functionOutcomes
2017
Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial
Irani M, Seifer DB, Grazi RV, Irani S, Rosenwaks Z, Tal R. Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial. Nutrients 2017, 9: 334. PMID: 28350328, PMCID: PMC5409673, DOI: 10.3390/nu9040334.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiomarkersBlood PressureBody Mass IndexDietary SupplementsFemaleHumansPolycystic Ovary SyndromeSingle-Blind MethodTriglyceridesVascular Endothelial Growth Factor AVitamin DVitamin D DeficiencyYoung AdultConceptsPolycystic ovary syndromeVascular endothelial growth factorOvarian hyperstimulation syndromeSerum VEGF levelsVitamin DVEGF levelsVitD supplementationVitD treatmentSeverity of OHSSSerum vascular endothelial growth factorRandomized placebo-controlled trialFerriman-Gallwey hirsutism scoreBeneficial effectsCharacteristic clinical abnormalitiesPlacebo-controlled trialVitamin D levelsVitamin D supplementationMultiple clinical parametersSignificant decreaseEndothelial growth factorD supplementationHirsutism scoreHyperstimulation syndromeVitD groupRandomized Placebo
2015
The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome
Tal R, Seifer DB, Arici A. The Emerging Role of Angiogenic Factor Dysregulation in the Pathogenesis of Polycystic Ovarian Syndrome. Seminars In Reproductive Medicine 2015, 33: 195-207. PMID: 26036901, DOI: 10.1055/s-0035-1552582.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeGrowth factorOvarian syndromePathophysiology of PCOSAngiogenic factor imbalanceOvarian hyperstimulation syndromeCommon endocrine disorderVascular endothelial growth factorPlatelet-derived growth factorBasic fibroblast growth factorMultiple angiogenic factorsEndothelial growth factorFibroblast growth factorHyperstimulation syndromeOvulatory dysfunctionStromal vascularityAnovulatory infertilityPolycystic ovariesEndocrine disordersReproductive ageTreatment strategiesFollicular growthOvarian angiogenesisAngiogenic factorsCorpus luteum
1998
Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential
Friedman C, Seifer D, Kennard E, Arbogast L, Alak B, Danforth D. Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertility And Sterility 1998, 70: 836-839. PMID: 9806563, DOI: 10.1016/s0015-0282(98)00301-x.Peer-Reviewed Original ResearchConceptsFF VEGF concentrationsAmpules of gonadotropinsVEGF concentrationsClinical pregnancyChart reviewFollicular fluid vascular endothelial growth factorFollicular fluid vascular endothelial growth factor concentrationsDay 3 FSH levelsFollicular fluid VEGF concentrationsVascular endothelial growth factor concentrationsClinical pregnancy rateEstradiol serum concentrationsPeak estradiol levelsRetrospective chart reviewUniversity teaching centerVascular endothelial growth factorNumber of oocytesYears of ageEndothelial growth factorGrowth factor concentrationsFF VEGFSingle IVFFSH levelsPatient ageEstradiol levels
1997
Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction
Friedman C, Danforth D, Herbosa-Encarnacion C, Arbogast L, Alak B, Seifer D. Follicular fluid vascular endothelial growth factor concentrations are elevated in women of advanced reproductive age undergoing ovulation induction. Fertility And Sterility 1997, 68: 607-612. PMID: 9341598, DOI: 10.1016/s0015-0282(97)00278-1.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgingCobaltCohort StudiesCorpus LuteumEndothelial Growth FactorsFemaleFollicular FluidGranulosa CellsHumansHypoxiaLymphokinesMaternal AgeMiddle AgedOsmolar ConcentrationOvulation InductionPregnancyPregnancy, High-RiskRetrospective StudiesTime FactorsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsAdvanced reproductive ageVascular endothelial growth factor/vascular permeability factorVascular permeability factorReproductive ageFollicular fluidFactor concentrationsPermeability factorFollicular fluid vascular endothelial growth factor concentrationsGranulosa cellsVascular endothelial growth factor concentrationsYoung womenRetrospective cohort studyReproductive-age womenUniversity Teaching HospitalPg/mLGrowth factor concentrationsCohort studyIVF-ETOvulation inductionHCG administrationAge womenCobalt chlorideTeaching hospitalMAIN OUTCOMEFollicular aspiration