Featured Publications
Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42
Seifer D, Wang S, Frankfurter D. Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42. Reproductive Biology And Endocrinology 2023, 21: 94. PMID: 37872609, PMCID: PMC10591412, DOI: 10.1186/s12958-023-01144-z.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth RateEmbryo TransferFemaleFertilization in VitroHumansLive BirthMiddle AgedOocytesPregnancyPregnancy RateReproductive Techniques, AssistedRetrospective StudiesConceptsCumulative live birth rateLive birth rateART cyclesBirth rateDesignRetrospective cohort studyPrior ART cyclesUse of ICSIEtiology of infertilityNumber of oocytesAge categoriesSART CORS databaseYears of ageTreatment cycle numberRace/ethnicityAutologous cyclesResultsBetween 2014Ovarian reserveCohort studyBlastocyst transferWomen 46Women 42Age 45Live birthsMAIN OUTCOMEPhysician expectationsState insurance mandates are necessary but not sufficient for closing the racial and ethnic disparity gap in assisted reproductive technology
Volovsky M, Seifer D. State insurance mandates are necessary but not sufficient for closing the racial and ethnic disparity gap in assisted reproductive technology. Fertility And Sterility 2023, 121: 46-47. PMID: 37816429, DOI: 10.1016/j.fertnstert.2023.10.003.Peer-Reviewed Original ResearchHealthcare DisparitiesHumansInsurance CoverageInsurance, HealthRacial GroupsReproductive Techniques, AssistedUnited StatesRacial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States
Beroukhim G, Seifer D. Racial and Ethnic Disparities in Access to and Outcomes of Infertility Treatment and Assisted Reproductive Technology in the United States. Endocrinology And Metabolism Clinics Of North America 2023, 52: 659-675. PMID: 37865480, DOI: 10.1016/j.ecl.2023.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Indian or Alaska NativeAsianBlack or African AmericanEthnicityFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansInfertilityInfertility, FemalePregnancyPregnancy OutcomeReproductive Techniques, AssistedSocial Determinants of HealthUnited StatesWhiteConceptsEthnic disparitiesInfertility treatmentIntrauterine insemination pregnancy ratesHigh infertility rateAmerican Indian womenAssisted Reproductive TechnologyClinical pregnancyObstetrical complicationsFertility carePregnancy lossFavorable outcomePregnancy rateInfertility rateLive birthsHigher oddsART outcomesHispanic womenWhite womenRobust studiesWomenIndian womenReproductive technologiesBlack womenOutcomesCare
2024
Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates
Wang S, Seifer D. Assessment of a Decade of Change in U.S. Assisted Reproductive Technology Cumulative Live-Birth Rates. Obstetrics And Gynecology 2024, 143: 839-848. PMID: 38696814, DOI: 10.1097/aog.0000000000005598.Peer-Reviewed Original ResearchMeSH KeywordsAdultBirth RateFemaleHumansInfertilityLive BirthMalePregnancyReproductive Techniques, AssistedRetrospective StudiesUnited StatesConceptsCumulative live birth rateLive birth rateAssisted reproductive technologyPreimplantation genetic testingInfertility diagnosisLive birthsOvulatory disordersGenetic testingReproductive technologyOdds of live birthMale factor infertilityFrozen embryo transferDiminished ovarian reserveClinical practiceRetrospective cohort studyAssociated with decreased oddsSART CORS databaseField of assisted reproductive technologyDemographic shiftsSART CORSOvarian reserveInfertility causeEmbryo transferCounseling patientsCohort studyAge-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT
Wang S, Seifer D. Age-related increase in live-birth rates of first frozen thaw embryo versus first fresh transfer in initial assisted reproductive technology cycles without PGT. Reproductive Biology And Endocrinology 2024, 22: 42. PMID: 38615016, PMCID: PMC11015537, DOI: 10.1186/s12958-024-01210-0.Peer-Reviewed Original ResearchMeSH KeywordsAgedBirth RateEmbryo TransferFemaleGenetic TestingHumansInfertility, MaleMaleOvarian DiseasesReproductive Techniques, AssistedRetrospective StudiesConceptsFrozen-thawed embryo transferCumulative live birth rateLive birth rateDiminished ovarian reservePreimplantation genetic testingMultivariate logistic regressionFresh transferLive birth outcomesLive birthsEmbryo transferAssisted reproductive technologyART cyclesEndometrial receptivityBirth outcomesFrozen-thawed embryo transfer cyclesOdds of live birthAssisted reproductive technology cyclesChance of live birthFresh embryo transferFrozen-thawed cyclesFrozen-thawed embryosMale factor infertilityRetrospective cohort studyEmbryo transfer methodsAge groups
2023
Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies
Liao C, Kotlyar A, Seifer D. Effect of state insurance mandates on racial/ethnic disparities in the utilization and outcomes of donor oocyte–assisted reproductive technologies. Fertility And Sterility 2023, 120: 111-122. PMID: 36871857, DOI: 10.1016/j.fertnstert.2023.02.037.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInfertilityInsurancePregnancyPregnancy OutcomeReproductive Techniques, AssistedRetrospective StudiesUnited StatesConceptsBody mass indexUterine factor infertilityBlack recipientsART cyclesHispanic recipientsWhite recipientsEthnic disparitiesState insurance mandatesFactor infertilityMass indexAsian recipientsOocyte recipientsDonor oocytesLive birthsAssisted Reproductive Technology Clinic Outcome Reporting SystemRetrospective cohort studyCumulative probabilityRecurrent pregnancy lossMultivariable Poisson regressionFrozen-thawed transfersReproductive technologiesHigher median agePreimplantation genetic testingNon-Hispanic whitesInsurance mandates
2021
AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*
Tal R, Seifer DB, Tal R, Granger E, Wantman E, Tal O. AMH Highly Correlates With Cumulative Live Birth Rate in Women with Diminished Ovarian Reserve Independent of Age*. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: 2754-2766. PMID: 33729496, DOI: 10.1210/clinem/dgab168.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnti-Mullerian HormoneBirth RateFemaleHumansLive BirthOvarian ReservePregnancyReproductive Techniques, AssistedConceptsCumulative live birth rateDiminished ovarian reserveLive birth rateSerum AMHLive birthsAge strataRetrieval cycleAntimüllerian hormone levelsReproductive technology cyclesCumulative live birthMain outcome measuresMultiple logistic regressionNumber of oocytesBirth rateRegression analysisPreimplantation genetic testingAddition of AMHPercentage of cyclesOvarian reserveIndependent predictorsOvarian responseHormone levelsRetrospective analysisOutcome measuresEmbryo transfer
2020
Status of racial disparities between black and white women undergoing assisted reproductive technology in the US
Seifer D, Simsek B, Wantman E, Kotlyar A. Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reproductive Biology And Endocrinology 2020, 18: 113. PMID: 33213467, PMCID: PMC7677830, DOI: 10.1186/s12958-020-00662-4.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateReproductive technology outcomesWhite non-Hispanic womenBody mass indexEtiology of infertilityNon-Hispanic womenMass indexBirth rateBlack womenWhite non-Hispanic patientsTechnology outcomesLogistic regressionWhite womenRetrospective cohort studyNon-Hispanic patientsIndependent prognostic factorIntra-cytoplasmic sperm injectionProportion of cyclesMultivariate logistic regressionMultiple logistic regressionReproductive technologiesNumber of embryosCycle cancellationOvarian reserveDo state insurance mandates alter ICSI utilization?
Zagadailov P, Seifer DB, Shan H, Zarek SM, Hsu AL. Do state insurance mandates alter ICSI utilization? Reproductive Biology And Endocrinology 2020, 18: 33. PMID: 32334609, PMCID: PMC7183130, DOI: 10.1186/s12958-020-00589-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleHumansInfant, NewbornInsuranceInsurance CoverageMalePopulation SurveillancePregnancyPregnancy OutcomePregnancy RateReproductive Techniques, AssistedRetrospective StudiesSperm Injections, IntracytoplasmicConceptsIntracytoplasmic sperm injectionElective single embryo transferClinical pregnancyICSI usePreimplantation genetic testingESET rateState insurance mandatesTwin rateInsurance mandatesRetrospective cohort studyLive birth rateLower clinical pregnancyMale factor infertilitySingle embryo transferBirth rateTwin birth rateT-testICSI rateLower LBRStrength of associationCohort studyFactor infertilityART cyclesResultsFrom 2000ART coverage
2019
A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed
Seifer DB, Kallen AN. A counterintuitive lesson in family planning? Patience first: taking a “gap year” after live birth from assisted reproductive technology before frozen embryo transfer is performed. Fertility And Sterility 2019, 111: 1109-1110. PMID: 31056317, DOI: 10.1016/j.fertnstert.2019.03.017.Peer-Reviewed Original ResearchBirth IntervalsEmbryo TransferFamily Planning ServicesFemaleHumansLive BirthPregnancyPregnancy OutcomeReproductive Techniques, Assisted
2018
Relevance of International Committee for Monitoring Assisted Reproductive Technology (ICMART) Registry report 2011
Seifer DB. Relevance of International Committee for Monitoring Assisted Reproductive Technology (ICMART) Registry report 2011. Fertility And Sterility 2018, 110: 1032-1033. PMID: 30396542, DOI: 10.1016/j.fertnstert.2018.07.011.Peer-Reviewed Original ResearchNational survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies
Seifer DB, Wantman E, Sparks AE, Luke B, Doody KJ, Toner JP, van Voorhis BJ, Lin PC, Reindollar RH. National survey of the Society for Assisted Reproductive Technology membership regarding insurance coverage for assisted reproductive technologies. Fertility And Sterility 2018, 110: 1081-1088.e1. PMID: 30396552, DOI: 10.1016/j.fertnstert.2018.07.016.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInsurance CoverageMalePregnancyPregnancy OutcomeReproductive Techniques, AssistedSocieties, MedicalSurveys and QuestionnairesUnited StatesConceptsElective single embryo transferHigh annual volumeInsurance coverageInfertility insurance coverageVulnerable populationsMultivariable logistic regressionOverall response rateSingle embryo transferReproductive technologiesSignificant predictive valueFertility preservationCancer patientsOdds ratioTransgender patientsMAIN OUTCOMEPredictive valueResponse rateNumber of casesPatientsPractice settingsLogistic regressionUninsured populationAnnual volumeMajority of respondentsGenetic disorders
2016
Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update
Toner JP, Coddington CC, Doody K, Van Voorhis B, Seifer DB, Ball GD, Luke B, Wantman E. Society for Assisted Reproductive Technology and assisted reproductive technology in the United States: a 2016 update. Fertility And Sterility 2016, 106: 541-546. PMID: 27301796, DOI: 10.1016/j.fertnstert.2016.05.026.Peer-Reviewed Original Research
2015
Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013
Seifer DB, Tal O, Wantman E, Edul P, Baker VL. Prognostic indicators of assisted reproduction technology outcomes of cycles with ultralow serum antimüllerian hormone: a multivariate analysis of over 5,000 autologous cycles from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System database for 2012–2013. Fertility And Sterility 2015, 105: 385-393.e3. PMID: 26515380, DOI: 10.1016/j.fertnstert.2015.10.004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersCryopreservationDatabases, FactualEmbryo TransferFemaleFertilityFertilization in VitroHumansInfertilityLinear ModelsLive BirthLogistic ModelsMiddle AgedMultivariate AnalysisOocyte RetrievalPatient SelectionPregnancyPregnancy RatePregnancy, MultipleReproductive Techniques, AssistedRetrospective StudiesRisk AssessmentRisk FactorsTreatment OutcomeYoung AdultConceptsLive birth rateAntimüllerian hormoneCancellation rateAMH levelsAssisted Reproductive Technology Clinic Outcome Reporting System databaseAssisted reproduction technology (ART) outcomesEmbryo cryopreservation ratesSerum antimüllerian hormoneTotal cancellation rateMultiple birth ratesReporting System databaseCycle startAutologous cyclesClinical pregnancyCycle cancellationPrognostic factorsAMH valuesFresh cyclesCycle outcomePrognostic indicatorAMH concentrationsRetrospective analysisMAIN OUTCOMEEmbryo transferMultivariate analysis
2013
Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimüllerian hormone
Toner JP, Seifer DB. Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimüllerian hormone. Fertility And Sterility 2013, 99: 1825-1830. PMID: 23548941, DOI: 10.1016/j.fertnstert.2013.03.001.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Mullerian HormoneBiomarkersFemaleFollicle Stimulating Hormone, HumanHumansInfertility, FemaleOvaryPatient SelectionPredictive Value of TestsPrognosisReproductive Techniques, Assisted
2012
Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates
Butts SF, Ratcliffe S, Dokras A, Seifer DB. Diagnosis and treatment of diminished ovarian reserve in assisted reproductive technology cycles of women up to age 40 years: the role of insurance mandates. Fertility And Sterility 2012, 99: 382-388.e7. PMID: 23102859, PMCID: PMC3561490, DOI: 10.1016/j.fertnstert.2012.09.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityFemaleHumansInfertility, FemaleInsurance CoverageMaternal AgePennsylvaniaPregnancyPregnancy RatePrevalencePrimary Ovarian InsufficiencyReproductive Techniques, AssistedYoung AdultConceptsLive birth rateAge 40 yearsART cyclesART coverageElevated FSHOvarian reserveTreatment outcomesReproductive technology treatment outcomesSpecific infertility diagnosisState insurance coverageReproductive technology cyclesDiminished ovarian reserveProportion of cyclesCross-sectional studyBirth rateReporting System databaseInsurance mandatesMix of patientsProvider factorsInfertility diagnosisMAIN OUTCOMEFSHSignificant associationTreatment prognosisAdditional studies
2011
Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve
Buyuk E, Seifer DB, Illions E, Grazi RV, Lieman H. Elevated body mass index is associated with lower serum anti-mullerian hormone levels in infertile women with diminished ovarian reserve but not with normal ovarian reserve. Fertility And Sterility 2011, 95: 2364-2368. PMID: 21529798, DOI: 10.1016/j.fertnstert.2011.03.081.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersBody Mass IndexCross-Sectional StudiesDown-RegulationFemaleFollicle Stimulating Hormone, HumanHumansInfertility, FemaleLinear ModelsNew YorkOocyte RetrievalOverweightOvulationOvulation InductionReproductive Techniques, AssistedRisk AssessmentRisk FactorsConceptsElevated body mass indexNormal ovarian reserveBody mass indexSerum AMH levelsOvarian reserveNumber of oocytesAMH levelsObese womenInfertile womenMass indexHormone levelsDay 3 serum FSH levelsSerum anti-Mullerian hormone (AMH) levelsAnti-Mullerian hormone levelsLow serum AMH levelsSerum antimullerian hormone (AMH) levelsNormal body mass indexAntimullerian hormone levelsReproductive technology cyclesSerum FSH levelsDiminished ovarian reserveIU/L.Cross-sectional studyOvarian hyperstimulationIVF cyclesCultural factors contributing to health care disparities among patients with infertility in Midwestern United States
Missmer SA, Seifer DB, Jain T. Cultural factors contributing to health care disparities among patients with infertility in Midwestern United States. Fertility And Sterility 2011, 95: 1943-1949. PMID: 21420677, DOI: 10.1016/j.fertnstert.2011.02.039.Peer-Reviewed Original ResearchConceptsInfertility careHospital-based fertility centerUniversity hospital-based fertility centerHealth care accessHealth care disparitiesAfrican American womenHealth care systemPercent of respondentsConsecutive womenMedian ageFertility centerPatient raceMAIN OUTCOMECare accessHispanic womenCare disparitiesSelf-administered surveyTreatment opinionsInfertilityWhite womenCare systemStigma of infertilityWomenDemographic characteristicsCare
2010
Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States
Seifer DB, Baker VL, Leader B. Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertility And Sterility 2010, 95: 747-750. PMID: 21074758, DOI: 10.1016/j.fertnstert.2010.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgingAmbulatory Care FacilitiesAnti-Mullerian HormoneCohort StudiesFemaleHumansInfertilityMiddle AgedReference ValuesReproductive Techniques, AssistedRetrospective StudiesUnited StatesYoung AdultConceptsAnti-Müllerian hormone valuesAMH valuesHormone valuesAge 35Mean AMH valueSerum AMH valuesAverage yearly decreaseYears of ageU.S. fertility clinicsSpecific medianAMH levelsClinical reference laboratoryRetrospective studyFertility centerReproductive ageMAIN OUTCOMEAge 40Rate of declineFertility clinicsReference laboratoryWomenAgeReproductive optionsYearly decreaseSD values
2009
Racial and ethnic differences in reproductive potential across the life cycle
Butts SF, Seifer DB. Racial and ethnic differences in reproductive potential across the life cycle. Fertility And Sterility 2009, 93: 681-690. PMID: 19939362, DOI: 10.1016/j.fertnstert.2009.10.047.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansInfertility, FemaleMenopausePubertyRacial GroupsReproductionReproductive Techniques, AssistedConceptsRacial disparitiesLive birth rateReproductive health outcomesEthnic groupsRace/ethnicityMenopausal symptomsClinical endpointsMenopausal transitionMEDLINE searchHispanic womenPotential confoundingHealth outcomesReproductive healthReproductive life cycleNumber of reportsPubertal onsetEarly pubertySmall sample sizeEthnic differencesIndependent effectsReproductive technologiesOutcomesBirth rateContinuum of eventsReproductive life span