Featured Publications
Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42
Seifer D, Wang S, Frankfurter D. Cumulative live birth rates with autologous oocytes plateau with fewer number of cycles for each year of age > 42. Reproductive Biology And Endocrinology 2023, 21: 94. PMID: 37872609, PMCID: PMC10591412, DOI: 10.1186/s12958-023-01144-z.Peer-Reviewed Original ResearchConceptsCumulative live birth rateLive birth rateART cyclesBirth rateDesignRetrospective cohort studyPrior ART cyclesUse of ICSIEtiology of infertilityNumber of oocytesAge categoriesSART CORS databaseYears of ageTreatment cycle numberRace/ethnicityAutologous cyclesResultsBetween 2014Ovarian reserveCohort studyBlastocyst transferWomen 46Women 42Age 45Live birthsMAIN OUTCOMEPhysician expectations
2021
Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review
Kotlyar AM, Seifer DB. Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review. Frontiers In Endocrinology 2021, 11: 593216. PMID: 33633682, PMCID: PMC7900163, DOI: 10.3389/fendo.2020.593216.Peer-Reviewed Original Research
2018
Temporal Differences in Utilization of Intracytoplasmic Sperm Injection Among U.S. Regions
Zagadailov P, Hsu A, Stern JE, Seifer DB. Temporal Differences in Utilization of Intracytoplasmic Sperm Injection Among U.S. Regions. Obstetrics And Gynecology 2018, 132: 310-320. PMID: 29995722, DOI: 10.1097/aog.0000000000002730.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCohort StudiesFemaleFertilization in VitroHumansInfertility, FemaleInfertility, MaleLive BirthMalePregnancyPregnancy RateRetrospective StudiesSperm Injections, IntracytoplasmicTreatment OutcomeUnited StatesUnited States Dept. of Health and Human ServicesYoung AdultConceptsLive birth rateUse of ICSIICSI rateICSI utilizationBirth rateRetrospective cohort studyMale factor infertilityHuman Services (HHS) regionsIntracytoplasmic sperm injectionYears of agePreimplantation genetic testingMale factor diagnosisDepartment of HealthNondonor cyclesCohort studyFertilization cyclesFactor infertilityMale factorSperm injectionMedical indicationsMagnitude of increaseClinicGenetic testingDisease controlICSI
2014
Putting ‘family’ back in family planning
Seifer DB, Minkoff H, Merhi Z. Putting ‘family’ back in family planning. Human Reproduction 2014, 30: 16-19. PMID: 25406182, DOI: 10.1093/humrep/deu304.Peer-Reviewed Original Research
2012
High frequency of discordance between antimüllerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers
Leader B, Hegde A, Baca Q, Stone K, Lannon B, Seifer DB, Broekmans F, Baker VL. High frequency of discordance between antimüllerian hormone and follicle-stimulating hormone levels in serum from estradiol-confirmed days 2 to 4 of the menstrual cycle from 5,354 women in U.S. fertility centers. Fertility And Sterility 2012, 98: 1037-1042. PMID: 22771028, DOI: 10.1016/j.fertnstert.2012.06.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnti-Mullerian HormoneChemistry, ClinicalEstradiolFemaleFertilityFollicle Stimulating Hormone, HumanHumansMenstrual CycleMiddle AgedOocytesOvulation InductionPredictive Value of TestsPrognosisReference StandardsReproductive MedicineRetrospective StudiesUnited StatesYoung AdultConceptsYears of ageFSH valuesSerum AMHAntimüllerian hormoneAMH valuesFertility centerCut pointsDay 2Clinical discordanceMenstrual cycle day 2Follicle-stimulating hormone levelsCycle day 2Reference laboratoryFollicle-stimulating hormoneLarger patient populationSingle reference laboratoryFrequency of discordanceAge-dependent fashionClinical cut pointsSame serum samplesOvarian stimulationPatient populationAMH testingMenstrual cycleHormone levels
2010
Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States
Seifer DB, Baker VL, Leader B. Age-specific serum anti-Müllerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertility And Sterility 2010, 95: 747-750. PMID: 21074758, DOI: 10.1016/j.fertnstert.2010.10.011.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormone valuesAMH valuesHormone valuesAge 35Mean AMH valueSerum AMH valuesAverage yearly decreaseYears of ageU.S. fertility clinicsSpecific medianAMH levelsClinical reference laboratoryRetrospective studyFertility centerReproductive ageMAIN OUTCOMEAge 40Rate of declineFertility clinicsReference laboratoryWomenAgeReproductive optionsYearly decreaseSD values
2007
Relationship of bariatric surgery to Müllerian-inhibiting substance levels
Merhi ZO, Minkoff H, Feldman J, Macura J, Rodriguez C, Seifer DB. Relationship of bariatric surgery to Müllerian-inhibiting substance levels. Fertility And Sterility 2007, 90: 221-224. PMID: 17727846, DOI: 10.1016/j.fertnstert.2007.05.073.Peer-Reviewed Original Research
2004
Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol
Hazout A, Bouchard P, Seifer DB, Aussage P, Junca AM, Cohen-Bacrie P. Serum antimüllerian hormone/müllerian-inhibiting substance appears to be a more discriminatory marker of assisted reproductive technology outcome than follicle-stimulating hormone, inhibin B, or estradiol. Fertility And Sterility 2004, 82: 1323-1329. PMID: 15533354, DOI: 10.1016/j.fertnstert.2004.03.061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Mullerian HormoneBiomarkersEstradiolFemaleFertilization in VitroFollicle Stimulating HormoneGlycoproteinsHumansInhibinsMultivariate AnalysisOsmolar ConcentrationOvulation InductionPredictive Value of TestsPregnancyPregnancy RateRetrospective StudiesTesticular HormonesTime FactorsTreatment OutcomeConceptsReproductive technology outcomesMullerian-inhibiting substanceYears of ageMultivariate regression analysisInhibin BPregnancy outcomesIVF outcomesAntimullerian hormoneHigher clinical pregnancy rateSerum samplesAvailable serum markersDay 3 FSHSerum antimullerian hormoneClinical pregnancy rateClinical pregnancy outcomesInhibin B levelsFollicle-stimulating hormoneConsecutive serum samplesMüllerian-inhibiting substanceGreater prognostic valueTechnology outcomesRegression analysisClinical pregnancyOvarian stimulationOvulation induction
1998
Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes
Whitacre K, Seifer D, Friedman C, Coskun S, Kennard E, Kim M, Alak B. Effects of ovarian source, patient age, and menstrual cycle phase on in vitro maturation of immature human oocytes. Fertility And Sterility 1998, 70: 1015-1021. PMID: 9848288, DOI: 10.1016/s0015-0282(98)00339-2.Peer-Reviewed Original ResearchConceptsGerminal vesicle breakdownOvarian sourceNuclear maturationPatient ageGynecologic surgeryFollicular phaseLuteal phaseImmature human oocytesFinal meiotic maturationMenstrual cycle phaseYears of agePercentage of oocytesCycle phaseMetaphase II stageIVF programMenstrual cyclePatient criteriaMAIN OUTCOMEVitro maturationPatientsHuman oocytesOocyte maturationMII stageOocyte's abilityVesicle breakdownElevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential
Friedman C, Seifer D, Kennard E, Arbogast L, Alak B, Danforth D. Elevated level of follicular fluid vascular endothelial growth factor is a marker of diminished pregnancy potential. Fertility And Sterility 1998, 70: 836-839. PMID: 9806563, DOI: 10.1016/s0015-0282(98)00301-x.Peer-Reviewed Original ResearchConceptsFF VEGF concentrationsAmpules of gonadotropinsVEGF concentrationsClinical pregnancyChart reviewFollicular fluid vascular endothelial growth factorFollicular fluid vascular endothelial growth factor concentrationsDay 3 FSH levelsFollicular fluid VEGF concentrationsVascular endothelial growth factor concentrationsClinical pregnancy rateEstradiol serum concentrationsPeak estradiol levelsRetrospective chart reviewUniversity teaching centerVascular endothelial growth factorNumber of oocytesYears of ageEndothelial growth factorGrowth factor concentrationsFF VEGFSingle IVFFSH levelsPatient ageEstradiol levelsDimeric inhibin: a direct marker of ovarian aging
Danforth D, Arbogast L, Mroueh J, Kim M, Kennard E, Seifer D, Friedman C. Dimeric inhibin: a direct marker of ovarian aging. Fertility And Sterility 1998, 70: 119-123. PMID: 9660432, DOI: 10.1016/s0015-0282(98)00127-7.Peer-Reviewed Original ResearchConceptsInhibin B levelsPerimenopausal transitionOvarian reserveRegular menstrual cyclesPituitary FSH secretionDaily urine samplesSubsequent follicular phaseCorpus luteum functionYears of ageDay of ovulationWomen 39FSH levelsInhibin secretionFSH secretionPerimenopausal womenSerum levelsLH surgeProspective studyOvarian functionFollicular phaseMenstrual cycleFifth decadeMAIN OUTCOMEBlood samplesLuteal secretion