Featured Publications
Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview
Han E, Seifer D. Oocyte Cryopreservation for Medical and Planned Indications: A Practical Guide and Overview. Journal Of Clinical Medicine 2023, 12: 3542. PMID: 37240648, PMCID: PMC10218997, DOI: 10.3390/jcm12103542.Peer-Reviewed Original ResearchOocyte cryopreservationAge-related fertility declineOvarian follicular lossFirst successful pregnancyElective oocyte cryopreservationFollicular lossGonadotoxic therapySuccessful pregnancyTreatment of cancerBiologic childrenFollicular fluidOvarian folliclesNarrative reviewMature oocytesOocytesPregnancyPatientsTherapyCancerFollicles
2020
Anti-Müllerian hormone as a qualitative marker - or just quantity?
Kotlyar A, Seifer DB. Anti-Müllerian hormone as a qualitative marker - or just quantity? Current Opinion In Obstetrics & Gynecology 2020, 32: 219-226. PMID: 32205525, DOI: 10.1097/gco.0000000000000623.Peer-Reviewed Original ResearchConceptsAnti-Müllerian hormoneOvarian reserve testingClinical pregnancy rateLive birth rateOnset of menopausePremature ovarian insufficiencyNumber of oocytesSignificant predictive valueAMH levelsFertilization cyclesPregnancy rateOvarian insufficiencyIntracycle variabilityOocyte qualityPredictive valueEarly folliclesFetal trisomiesHormoneReproductive technologiesRiskQualitative markersSmall interMenopauseInsufficiencyFollicles
2000
NEW TREATMENTS OF HYPERANDROGENISM AND HIRSUTISM
Hock DL, Seifer DB. NEW TREATMENTS OF HYPERANDROGENISM AND HIRSUTISM. Obstetrics And Gynecology Clinics Of North America 2000, 27: 567-581. PMID: 10958004, DOI: 10.1016/s0889-8545(05)70156-x.Peer-Reviewed Original ResearchConceptsAndrogen effectsAdministration of antiandrogensForm of hirsutismMost patientsMedical therapyHormonal suppressionAndrogen productionPhysical therapyNew treatmentsFemale populationHair folliclesBody hairHirsutismTherapyHair removalTreatment methodsHyperandrogenismAntiandrogensPatientsFolliclesAdministration
1996
Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†
Seifer D, Gardiner A, Ferreira K, Peluso J. Apoptosis as a function of ovarian reserve in women undergoing in vitro fertilization*†. Fertility And Sterility 1996, 66: 593-598. PMID: 8816622, DOI: 10.1016/s0015-0282(16)58573-2.Peer-Reviewed Original ResearchConceptsDay 3 serum FSHFSH levelsOvarian reserveSerum FSHMIU/Granulosa cellsCell countDiminished ovarian reserveMIU/mLAcademic clinical practiceLuteinized granulosa cellsApoptotic granulosa cellsIVF-ETFollicular aspiratesPreovulatory folliclesClinical practiceFlow cytometryWomenMean numberApoptotic cellsFSHGreater percentageFolliclesCellsViable cells
1995
Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*
Seifer DB, Giudice LC, Dsupin BA, Haning RV, Frishman GN, Burger HG. Endocrinology: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone*. Human Reproduction 1995, 10: 804-806. PMID: 7650124, DOI: 10.1093/oxfordjournals.humrep.a136042.Peer-Reviewed Original ResearchConceptsDay 3 serum follicleInsulin-like growth factorFollicular fluid concentrationsFSH groupSerum follicleIGF-IIGrowth factorFollicular fluid insulin-like growth factorMean IGF-II concentrationsFluid concentrationsMean IGF-I concentrationInsulin-like growth factor II concentrationsDay 3 FSHFollicular fluid IGFIGF-II concentrationsIGF-I concentrationsFactor II concentrationsFollicular fluid aspirationInhibin concentrationsFluid aspirationEmbryo transferFolliclesIGFHormoneGroup
1993
Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content
Seifer DB, MacLaughlin DT, Penzias AS, Behrman HR, Asmundson L, Donahoe PK, Haning RV, Flynn SD. Gonadotropin-releasing hormone agonist-induced differences in granulosa cell cycle kinetics are associated with alterations in follicular fluid müllerian-inhibiting substance and androgen content. The Journal Of Clinical Endocrinology & Metabolism 1993, 76: 711-714. PMID: 8445031, DOI: 10.1210/jcem.76.3.8445031.Peer-Reviewed Original ResearchConceptsHuman menopausal gonadotropinCell cycle kineticsProliferative indexGranulosa cellsFollicular fluidControl groupCycle kineticsGnRH analogue leuprolideOvulation induction regimensFollicular fluid contentMüllerian-inhibiting substanceHuman granulosa cellsLuteinized granulosa cellsCI (3.2-3.6) PInduction regimensMenopausal gonadotropinOocyte retrievalAndrogen contentGnRHSpecific growth factorsFlow cytometryGrowth factorFolliclesFluid contentOne-way analysis