Featured Publications
Tissue Age Affects Antigenicity and Scoring for the 22C3 Immunohistochemistry Companion Diagnostic Test
Fernandez A, Gaule P, Rimm D. Tissue Age Affects Antigenicity and Scoring for the 22C3 Immunohistochemistry Companion Diagnostic Test. Modern Pathology 2023, 36: 100159. PMID: 36925070, PMCID: PMC10502188, DOI: 10.1016/j.modpat.2023.100159.Peer-Reviewed Original ResearchConceptsPD-L1 signalTumor proportion scoreTissue microarray cohortCell lung cancerPrevious clinical diagnosisWhole tissue sectionsCompanion diagnostic testsMultiple cancer typesMicroarray cohortTMA cohortLaboratory-developed testsPD-L1NSCLC casesLung cancerProportion scorePositive stainingAntibody 22C3Immunohistochemistry testsClinical diagnosisExtracellular domainCancer typesDiagnostic testsArchival tissueDomain antigenAntibodies
2000
Validation of Tissue Microarray Technology in Breast Carcinoma
Camp R, Charette L, Rimm D. Validation of Tissue Microarray Technology in Breast Carcinoma. Laboratory Investigation 2000, 80: 1943-1949. PMID: 11140706, DOI: 10.1038/labinvest.3780204.Peer-Reviewed Original ResearchConceptsWhole tissue sectionsInvasive breast carcinomaBreast carcinomaTissue microarray technologyLarge-scale retrospective cohort studyTissue sectionsArchival tissueRetrospective cohort studyHER2/neu oncogeneTissue microarray techniqueCohort studyBreast cancer microarrayProgesterone receptorArchival cohortEstrogen receptorAmount of tissueCommon antigenNeu oncogeneEntire tumorCarcinomaProtein expressionProtein expression patternsArchival formalinTissueReceptors