Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab
Boster AL, Nicholas JA, Topalli I, Kisanuki YY, Pei W, Morgan-Followell B, Kirsch CF, Racke MK, Pitt D. Lessons Learned From Fatal Progressive Multifocal Leukoencephalopathy in a Patient With Multiple Sclerosis Treated With Natalizumab. JAMA Neurology 2013, 70: 398-402. PMID: 23338729, DOI: 10.1001/jamaneurol.2013.1960.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathyBrain magnetic resonance imagingMagnetic resonance imagingMultiple sclerosisResonance imagingMultifocal leukoencephalopathyPolymerase chain reaction testingFatal progressive multifocal leukoencephalopathyBenefits of natalizumabInfusions of natalizumabPML risk stratificationAntibody-positive patientsHigh-dose corticosteroidsCerebrospinal fluid studiesHigh clinical suspicionCerebrospinal fluid analysisBrain magnetic resonanceNegative test resultsPolymerase chain reaction resultsSubacute onsetBilateral blindnessClinical suspicionClinical vigilanceCortical demyelinationTherapy duration