2004
Glutamate Excitotoxicity in Multiple Sclerosis
Pitt D, Raine C. Glutamate Excitotoxicity in Multiple Sclerosis. 2004, 285-303. DOI: 10.1007/978-1-4419-8959-8_16.Peer-Reviewed Original ResearchGlutamate excitotoxicityMultiple sclerosisWhite matter injuryCentral white matterProminent demyelinationMS pathogenesisOligodendrocyte damageInflammatory demyelinationOligodendrocyte lossExtracellular glutamateGlutamate homeostasisAnimal modelsExcitotoxicityWhite matterCell targetsClearance pathwaysCommon pathwayDisease mechanismsCell culture studiesDemyelinationSclerosisRecent dataOligodendrocytesCulture studiesPathogenesis
2001
Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
Werner P, Pitt D, Raine C. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Annals Of Neurology 2001, 50: 169-180. PMID: 11506399, DOI: 10.1002/ana.1077.Peer-Reviewed Original ResearchConceptsMultiple sclerosisAxonal damageWhite matterGlutamate excitotoxicityGlutamate homeostasisMS lesionsGlutaminase expressionMS white matterInflammatory neurologic diseasesActive MS lesionsCNS cell typesOligodendroglial pathologyNoninflammatory conditionsDystrophic axonsNeurologic diseaseGLT-1Low-level expressionAnimal modelsGlutamate transportersHomeostasis contributesLesion correlatesGlutamate transportLesionsOligodendrocytesTherapeutic import