2015
The Cost-effectiveness and Budget Impact of 2-Drug Dolutegravir-Lamivudine Regimens for the Treatment of HIV Infection in the United States
Girouard MP, Sax PE, Parker RA, Taiwo B, Freedberg KA, Gulick RM, Weinstein MC, Paltiel AD, Walensky RP. The Cost-effectiveness and Budget Impact of 2-Drug Dolutegravir-Lamivudine Regimens for the Treatment of HIV Infection in the United States. Clinical Infectious Diseases 2015, 62: 784-791. PMID: 26658053, PMCID: PMC4772845, DOI: 10.1093/cid/civ981.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioStandard of careVirologic suppressionART costsBudget impactHuman immunodeficiency virus (HIV) treatmentART-naive patientsDTG/ABC/3TCVirologic suppression ratesSubsequent virologic failureCost-effectiveness ratioPerson/yearInitial regimenAntiretroviral therapyInduction regimenNaive patientsVirologic failureAntiretroviral agentsDual therapyHIV infectionTwo-drugDolutegravirVirus treatmentRegimenSurvival rate
2014
Cost-effectiveness of canine vaccination to prevent human rabies in rural Tanzania.
Fitzpatrick MC, Hampson K, Cleaveland S, Mzimbiri I, Lankester F, Lembo T, Meyers LA, Paltiel AD, Galvani AP. Cost-effectiveness of canine vaccination to prevent human rabies in rural Tanzania. Annals Of Internal Medicine 2014, 160: 91-100. PMID: 24592494, PMCID: PMC4084874, DOI: 10.7326/m13-0542.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBites and StingsCost-Benefit AnalysisDog DiseasesDogsHumansModels, StatisticalRabiesRabies VaccinesRural PopulationTanzaniaVaccinationConceptsVaccination campaignCanine vaccinationPrompt postexposure prophylaxisBase-case analysisVaccination coverageHuman rabiesSocietal willingnessProbability-based evaluationU.S. dollarsEconomic outcomesContact-tracing studiesEmpirical uncertaintyRural AfricaRural TanzaniaOptimal vaccination coverageOngoing vaccination campaignRabies vaccination campaignsGreat uncertaintyAnnual mortality ratePostexposure prophylaxisEpidemiologic variablesTransmission of rabiesHealth burdenWillingnessMortality rate
2012
Model Parameter Estimation and Uncertainty: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6
Briggs AH, Weinstein MC, Fenwick EA, Karnon J, Sculpher MJ, Paltiel AD, Force I. Model Parameter Estimation and Uncertainty: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-6. Value In Health 2012, 15: 835-842. PMID: 22999133, DOI: 10.1016/j.jval.2012.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdvisory CommitteesComparative Effectiveness ResearchDecision MakingHealth Care RationingModels, StatisticalModels, TheoreticalUncertaintyConceptsDecision uncertaintyCost-effectiveness acceptability curvesHealth care resource allocationEconomic evidence basePoint estimatesReporting of uncertaintyAcceptability curvesLevel of uncertaintyPolicy perspectivePerfect informationPrecise point estimatesPresentational techniquesDecision makersDecision modelingResource allocationParameter uncertaintiesBetter decisionsStructural uncertaintyDecisionsModel purposeUncertaintyInformation analysisModel-based analysisExtensive recommendationsStochastic uncertainty
2011
Medical Device Innovation — Is “Better” Good Enough?
Suter LG, Paltiel AD, Rome BN, Solomon DH, Golovaty I, Gerlovin H, Katz JN, Losina E. Medical Device Innovation — Is “Better” Good Enough? New England Journal Of Medicine 2011, 365: 1464-1466. PMID: 22010911, PMCID: PMC3570242, DOI: 10.1056/nejmp1109285.Peer-Reviewed Original ResearchProjected Survival Gains from Revising State Laws Requiring Written Opt-in Consent for HIV Testing
April MD, Chiosi JJ, Paltiel AD, Sax PE, Walensky RP. Projected Survival Gains from Revising State Laws Requiring Written Opt-in Consent for HIV Testing. Journal Of General Internal Medicine 2011, 26: 661-667. PMID: 21286837, PMCID: PMC3101973, DOI: 10.1007/s11606-011-1637-5.Peer-Reviewed Original ResearchConceptsPotential survival gainsSurvival gainHIV testingDiagnosis rateAnnual HIV incidenceProportion of HIVUndiagnosed HIV prevalenceAnnual HIV diagnosis ratesHIV diagnosis ratesHIV incidenceHIV prevalenceEarly diagnosisHIVDisease controlLYGSurveillance dataAdult personsConsentConsent methodsPersonsPatientsConsent lawsBackgroundAlthoughDesignWeObjectiveTo
2006
Cost-Effectiveness of an Intervention to Improve Adherence to Antiretroviral Therapy in HIV-Infected Patients
Freedberg KA, Hirschhorn LR, Schackman BR, Wolf LL, Martin LA, Weinstein MC, Goldin S, Paltiel AD, Katz C, Goldie SJ, Losina E. Cost-Effectiveness of an Intervention to Improve Adherence to Antiretroviral Therapy in HIV-Infected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2006, 43: s113-s118. PMID: 17133193, DOI: 10.1097/01.qai.0000248334.52072.25.Peer-Reviewed Original ResearchConceptsStandard careNursing interventionsClinical trialsLong-term survival benefitIncremental cost-effectiveness ratioCohort of HIVQuality-adjusted life yearsLifetime medical costsCost-effectiveness ratioVirologic suppressionAntiretroviral therapyViral suppressionAntiretroviral medicationsHIV diseaseSurvival benefitClinical outcomesAdherence interventionsAntiretroviral adherenceMedical costsLife yearsModest effectivenessPatientsInterventionAdherenceHIV
2005
Optimal Allocation of Testing Dollars: The Example of HIV Counseling, Testing, and Referral
Walensky RP, Weinstein MC, Smith HE, Freedberg KA, Paltiel AD. Optimal Allocation of Testing Dollars: The Example of HIV Counseling, Testing, and Referral. Medical Decision Making 2005, 25: 321-329. PMID: 15951459, DOI: 10.1177/0272989x05276955.Peer-Reviewed Original ResearchMeSH KeywordsAIDS SerodiagnosisComputer SimulationContinuity of Patient CareCost-Benefit AnalysisCounselingDecision Support TechniquesHIV InfectionsHumansInvestmentsMass ScreeningModels, StatisticalPatient Acceptance of Health CarePrevalenceProbabilityQuality-Adjusted Life YearsReferral and ConsultationResource AllocationSensitivity and SpecificityUnited StatesConceptsCost-effectiveness ratioScreening programUndiagnosed HIV prevalenceHealth screening programHIV testing servicesHIV testingHIV counselingHIV prevalenceLimited screening resourcesClinical impactAppropriate careQALYTesting pathwayTesting servicesScreening resourcesPathway outcomesOptimal targetingCarePathwayEarly stagesHIVReferralAdditional peopleFollowLater stages
2001
Use of Health Services by Insurance Status Among Children With Asthma
Ortega A, Belanger K, Paltiel A, Horwitz S, Bracken M, Leaderer B. Use of Health Services by Insurance Status Among Children With Asthma. Medical Care 2001, 39: 1065-1074. PMID: 11567169, DOI: 10.1097/00005650-200110000-00004.Peer-Reviewed Original ResearchConceptsPrimary care visitsHealth care useEmergency departmentInsurance statusCare visitsAsthmatic childrenMedication useCare useAsthma-related risk factorsRoutine primary care visitsProspective cohort studyHealth care visitsHealth care utilizationChildhood asthma severityPatient-provider communicationWhite childrenMedical DictionaryNew England hospitalsRace/ethnicityAsthma specialistCohort studyMedicaid childrenAsthma severityIndependent predictorsCare utilization