2011
Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites
Casale A, McCormick D. Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites. Journal Of Neuroscience 2011, 31: 18289-18302. PMID: 22171033, PMCID: PMC3269759, DOI: 10.1523/jneurosci.4417-11.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusSomatic current injectionAction potentialsDendritic arborsGeniculate nucleusSynaptic stimulationThalamic interneuronsMouse dorsal lateral geniculate nucleusDendritic neurotransmitter releaseEntire dendritic arborSingle action potentialAxon initial segmentVoltage-gated sodiumProximal dendritesDendritic appendagesInhibitory neurotransmitterExcitatory inputsInhibitory interneuronsVoltage-sensitive dyeSynaptic inputsThalamocortical cellsCalcium transientsCalcium imagingNeurotransmitter release
2010
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2009
Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17
Nowak L, Sanchez-Vives M, McCormick D. Spatial and Temporal Features of Synaptic to Discharge Receptive Field Transformation in Cat Area 17. Journal Of Neurophysiology 2009, 103: 677-697. PMID: 19906874, PMCID: PMC2822677, DOI: 10.1152/jn.90946.2008.Peer-Reviewed Original Research
2007
Selective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesNeocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibitionModulation of intracortical synaptic potentials by presynaptic somatic membrane potential
Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick D. Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 2006, 441: 761-765. PMID: 16625207, DOI: 10.1038/nature04720.Peer-Reviewed Original ResearchConceptsIntracortical synaptic potentialsSomatic membrane potentialCerebral cortexMembrane potentialPostsynaptic potentialsSynaptic potentialsSynaptic activityEpileptic seizuresAction potentialsSensory stimulationNeuronal communicationMembrane potential changesNeuronal signalsRecording pointsSole formPossible alternative mechanismSeizuresCortexAxonsNeurons
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2003
Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons
Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick D. Barrages of Synaptic Activity Control the Gain and Sensitivity of Cortical Neurons. Journal Of Neuroscience 2003, 23: 10388-10401. PMID: 14614098, PMCID: PMC6741011, DOI: 10.1523/jneurosci.23-32-10388.2003.Peer-Reviewed Original ResearchConceptsSynaptic activityCortical neuronsLayer 5 pyramidal cellsVisual cortical slicesInhibitory synaptic activityOngoing synaptic activityEnhancement of responsivenessAction potential activationBackground synaptic activityExcitatory postsynaptic conductancesSpike-timing precisionInput-output curvesProbability of responseNeuronal responsivenessCortical slicesPyramidal cellsIntracellular recordingsSynaptic inputsSpontaneous periodSynaptic bombardmentSynaptic barragesPostsynaptic conductanceMembrane depolarizationNeuronal processingCortical cells
2001
Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons
Lüthi A, Di Paolo G, Cremona O, Daniell L, De Camilli P, McCormick D. Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons. Journal Of Neuroscience 2001, 21: 9101-9111. PMID: 11717343, PMCID: PMC6763888, DOI: 10.1523/jneurosci.21-23-09101.2001.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornCells, CulturedCerebral CortexElectric StimulationExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidMiceNerve Tissue ProteinsNeural InhibitionNeuronsPatch-Clamp TechniquesPhosphatidylinositolsPhosphoric Monoester HydrolasesSodium Channel BlockersSynapsesSynaptic TransmissionSynaptic VesiclesConceptsPaired-pulse depressionHalf-maximal depressionSteady-state depressionSynaptic depressionWhole-cell patch-clamp recordingsSlow depressionInhibitory synaptic responsesPaired-pulse protocolPrimary cortical culturesHigh-frequency stimulationPatch-clamp recordingsBi-exponential time courseUnitary IPSCsGABA releaseGABAergic transmissionCortical culturesPostsynaptic responsesCortical neuronsInhibitory synapsesSynaptic responsesSynaptojanin 1Presynaptic stimulationInhibitory neuronsRelease probabilityStimulation frequency
1997
Functional Dynamics of GABAergic Inhibition in the Thalamus
Kim U, Sanchez-Vives M, McCormick D. Functional Dynamics of GABAergic Inhibition in the Thalamus. Science 1997, 278: 130-134. PMID: 9311919, DOI: 10.1126/science.278.5335.130.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsBicucullineDendritesFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidIn Vitro TechniquesLysineNeuronsOrganophosphorus CompoundsPatch-Clamp TechniquesPresynaptic TerminalsReceptors, GABA-AReceptors, GABA-BSynaptic TransmissionThalamic NucleiConceptsInhibitory postsynaptic potentialsGABAergic inhibitionThalamic reticularThalamocortical networkLow-frequency tonic dischargeGABAergic inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusPatterns of activityLateral geniculate nucleusSlow-wave sleepPerigeniculate neuronsTonic dischargeGABAB receptorsThalamocortical neuronsPerigeniculate cellsPostsynaptic potentialsGABAA receptorsGeniculate nucleusThalamocortical cellsNeuronsGeneration of activityReceptorsReticularDistinct patternsInhibitionInfluence of low and high frequency inputs on spike timing in visual cortical neurons.
Nowak L, Sanchez-Vives M, McCormick D. Influence of low and high frequency inputs on spike timing in visual cortical neurons. Cerebral Cortex 1997, 7: 487-501. PMID: 9276174, DOI: 10.1093/cercor/7.6.487.Peer-Reviewed Original ResearchConceptsCortical neuronsAction potentialsFerret visual cortexAction potential dischargeVisual cortical neuronsInterspike intervalsAction potential generationAction potential timingTemporal precisionPostsynaptic potentialsGamma frequency rangeIntracellular recordingsIntracellular injectionVisual cortexPotential dischargeNeuronsVisual stimulationCortical networksRegular spikingSensory stimuliSingle trialHigh temporal precisionPotential timingHigh frequencyPotential generationSynchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h
Bal T, McCormick D. Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h. Journal Of Neurophysiology 1997, 77: 3145-3156. PMID: 9212264, DOI: 10.1152/jn.1997.77.6.3145.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Inferior olive nucleusIO neuronsGuinea pigsHyperpolarization-activated cationic currentLocal applicationDependent action potentialsPresence of apaminMembrane potentialInferior olive neuronsIntracellular recordingsIntracellular injectionPacemaker potentialsRhythmic generationInferior oliveAfterhyperpolarizationAction potentialsCationic currentRemoval of inactivationExtracellular applicationNeuronsHyperpolarizationApaminCa2Pigs
1995
Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro
Kim U, Bal T, McCormick D. Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro. Journal Of Neurophysiology 1995, 74: 1301-1323. PMID: 7500152, DOI: 10.1152/jn.1995.74.3.1301.Peer-Reviewed Original Research
1994
Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse
Ramoa A, McCormick D. Enhanced activation of NMDA receptor responses at the immature retinogeniculate synapse. Journal Of Neuroscience 1994, 14: 2098-2105. PMID: 7908957, PMCID: PMC6577156, DOI: 10.1523/jneurosci.14-04-02098.1994.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAfferent PathwaysAgingAnimalsBicucullineElectric StimulationEvoked PotentialsFerretsGeniculate BodiesIn Vitro TechniquesKineticsNeuronsQuinoxalinesReceptors, N-Methyl-D-AspartateRetinaSynapsesSynaptic TransmissionTime FactorsVisual PathwaysConceptsNMDA receptorsBicuculline methiodideNMDA-EPSCsPostnatal monthPostnatal weekGABAA receptor-mediated IPSPsAMPA/kainate receptorsOptic tract stimulationReceptor-mediated IPSPsExcitatory postsynaptic currentsNMDA receptor responsesFirst postnatal monthSecond postnatal weekVoltage-clamp recordingsDorsal LGNEPSC durationRetinogeniculate transmissionD-APVSlow EPSPTract stimulationExcitatory transmissionGABAergic inhibitionNeonatal ageRetinogeniculate synapsePostsynaptic currents
1993
A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons
Destexhe A, McCormick D, Sejnowski T. A model for 8–10 Hz spindling in interconnected thalamic relay and reticularis neurons. Biophysical Journal 1993, 65: 2473-2477. PMID: 8312485, PMCID: PMC1225988, DOI: 10.1016/s0006-3495(93)81297-9.Peer-Reviewed Original ResearchConceptsReticular cellsReticular thalamic cellsInhibitory postsynaptic potentialsIntrinsic oscillatory propertiesReticularis neuronsSpindle rhythmicityPostsynaptic potentialsInhibitory synapsesThalamic cellsThalamic relayThalamocortical cellsSilent periodSynaptic interactionsSpindle oscillationsRhythmic oscillationsCellsControl of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang Z, McCormick D. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD. Journal Of Neuroscience 1993, 13: 2199-2216. PMID: 8386756, PMCID: PMC6576582, DOI: 10.1523/jneurosci.13-05-02199.1993.Peer-Reviewed Original ResearchConceptsIntracellular recordingsMetabotropic receptorsPyramidal cellsLayer V pyramidal cellsGlutamate metabotropic receptor agonistLayer V cellsMetabotropic receptor agonistApplication of norepinephrineAlpha-agonist phenylephrineBeta-antagonist propranololSingle spike activityMuscarinic antagonist scopolamineBeta-agonist isoprenalinePrimary visual cortexAction potential generationSingle-spike modeACh effectsMuscarinic subtypesNE responseInterburst frequencyMuscarinic agonistsReceptor agonistBath applicationPostsynaptic responsesAntagonist scopolamine
1992
Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors.
McCormick D, von Krosigk M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 2774-2778. PMID: 1313567, PMCID: PMC48745, DOI: 10.1073/pnas.89.7.2774.Peer-Reviewed Original ResearchConceptsSlow-wave sleepCerebral cortexThalamic neuronsRelay neuronsWave sleepLateral geniculate relay neuronsProlonged excitatory postsynaptic potentialGeniculate relay neuronsLayer VI cellsExcitatory postsynaptic potentialsThalamic relay neuronsSensory informationSingle-spike modeBrainstem inputsPostsynaptic potentialsCorticothalamic fibersSlow depolarizationObligatory relayState-dependent mannerSensory transferThalamusMammalian thalamusPotassium conductanceProlonged enhancementNeuronsNeurotransmitter Actions in the Thalamus and Cerebral Cortex
McCormick D. Neurotransmitter Actions in the Thalamus and Cerebral Cortex. Journal Of Clinical Neurophysiology 1992, 9: 212-223. PMID: 1350591, DOI: 10.1097/00004691-199204010-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArousalCerebral CortexHumansNeural InhibitionNeurotransmitter AgentsReceptors, NeurotransmitterSynaptic TransmissionThalamusConceptsGamma-aminobutyric acidCerebral cortexThalamocortical activityInhibitory amino acidsSleep-wake cyclePostsynaptic actionsCortical neuronsNeurotransmitter actionEpileptic seizuresSynaptic informationTransmitter actionThalamusNorepinephrineAcetylcholineCortexNeurotransmittersSeizuresExcitabilityNeocortexHistamineExcitatoryState of activityNeuronsActivity
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance