2024
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortex
2021
Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations
Nestvogel D, McCormick D. Visual thalamocortical mechanisms of waking state-dependent activity and alpha oscillations. Neuron 2021, 110: 120-138.e4. PMID: 34687663, PMCID: PMC8815448, DOI: 10.1016/j.neuron.2021.10.005.Peer-Reviewed Original ResearchConceptsState-dependent activityAlpha-like rhythmVisual thalamusAwake animalsMovement-related activationHz oscillationsPrimary visual cortexLow-threshold CaThalamic neuronsMovement-related signalsIntracellular recordingsThalamocortical cellsThalamocortical mechanismsCell-intrinsic propertiesVisual cortexThalamocortical interactionsBehavioral statesThalamusNeural mechanismsAlpha oscillationsNeuronsDistinct patternsV1Movement signalsRhythmVagus nerve stimulation induces widespread cortical and behavioral activation
Collins L, Boddington L, Steffan P, McCormick D. Vagus nerve stimulation induces widespread cortical and behavioral activation. Current Biology 2021, 31: 2088-2098.e3. PMID: 33740425, DOI: 10.1016/j.cub.2021.02.049.Peer-Reviewed Original ResearchConceptsVagus nerve stimulationCalcium imagingNeuromodulatory systemsVagus nerve transectionAuditory cortical regionsWidefield calcium imagingArousal stateDose-dependent activationNerve transectionVNS effectsNerve stimulationExcitatory activityCortical axonsModulatory pathwaysExcitatory neuronsLight anesthesiaNeurological conditionsTherapeutic mechanismMouse modelStimulation inducesArousal state changesCortical activityCortical stateMotor activityCortical regions
2020
Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains
de Gee J, Tsetsos K, Schwabe L, Urai A, McCormick D, McGinley M, Donner T. Pupil-linked phasic arousal predicts a reduction of choice bias across species and decision domains. ELife 2020, 9: e54014. PMID: 32543372, PMCID: PMC7297536, DOI: 10.7554/elife.54014.Peer-Reviewed Original ResearchConceptsPhasic arousalArousal systemMemory-based decisionsSound detection taskDecision-relevant evidenceBrain arousal systemsChoice biasesChoice biasLiberal biasesDecision domainArousalBehavioral effectsBias suppressionBiasesAmbiguous evidenceRapid dilationSuch decisionsMemoryPupilsTaskDecisionsHumansEvidenceGeneral principlesBias
2019
Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance
Neske G, Nestvogel D, Steffan P, McCormick D. Distinct Waking States for Strong Evoked Responses in Primary Visual Cortex and Optimal Visual Detection Performance. Journal Of Neuroscience 2019, 39: 10044-10059. PMID: 31672787, PMCID: PMC6978938, DOI: 10.1523/jneurosci.1226-18.2019.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexSensory processingVisual detection performanceCortical neuronal responsesCortical sensory processingWhole-cell recordingsMouse visual systemSensory cortical activityNeuronal membrane potentialArousal levelNeuronal responsivenessFunction of arousalMice increasesNeuronal responsesCortical activityV1 responsesVisual detection taskCortexSensory stimuliSensory responsesLocomotion periodsVisual stimuliBehavioral performanceMembrane potential
2018
The temporal organization of mouse ultrasonic vocalizations
Castellucci G, Calbick D, McCormick D. The temporal organization of mouse ultrasonic vocalizations. PLOS ONE 2018, 13: e0199929. PMID: 30376572, PMCID: PMC6207298, DOI: 10.1371/journal.pone.0199929.Peer-Reviewed Original ResearchConceptsUltrasonic vocalizationsAdult male C57BL/6J miceMale C57BL/6J miceMouse ultrasonic vocalizationsUSV productionC57BL/6J miceMale miceMouse modelRespiratory patternCommon biological mechanismsMiceMale ultrasonic vocalizationsAdults reliesBiological mechanismsRhythmic seriesTemporal organizationVocalization productionAdult malesHuman diseasesSpectrotemporal featuresFirst reportArticulatory patternsMammalian species
2015
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activitiesCortical Membrane Potential Signature of Optimal States for Sensory Signal Detection
McGinley MJ, David SV, McCormick DA. Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection. Neuron 2015, 87: 179-192. PMID: 26074005, PMCID: PMC4631312, DOI: 10.1016/j.neuron.2015.05.038.Peer-Reviewed Original ResearchConceptsCortical neuronsAuditory cortical neuronsSound-evoked responsesSensory-evoked responsesBackground synaptic activityMembrane potentialTonic periodsSignal detection behaviorSynaptic activityStable hyperpolarizationMembrane potential activitySlow oscillationsHippocampal recordingsNeural correlatesNeuronsTask performanceArousalPotential activityDetection behaviorPhysiological signaturesNoise detection taskArousal measuresMiceActivity
2013
Motor Cortex Feedback Influences Sensory Processing by Modulating Network State
Zagha E, Casale AE, Sachdev RN, McGinley MJ, McCormick DA. Motor Cortex Feedback Influences Sensory Processing by Modulating Network State. Neuron 2013, 79: 567-578. PMID: 23850595, PMCID: PMC3742632, DOI: 10.1016/j.neuron.2013.06.008.Peer-Reviewed Original Research
2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2011
Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites
Casale A, McCormick D. Active Action Potential Propagation But Not Initiation in Thalamic Interneuron Dendrites. Journal Of Neuroscience 2011, 31: 18289-18302. PMID: 22171033, PMCID: PMC3269759, DOI: 10.1523/jneurosci.4417-11.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusSomatic current injectionAction potentialsDendritic arborsGeniculate nucleusSynaptic stimulationThalamic interneuronsMouse dorsal lateral geniculate nucleusDendritic neurotransmitter releaseEntire dendritic arborSingle action potentialAxon initial segmentVoltage-gated sodiumProximal dendritesDendritic appendagesInhibitory neurotransmitterExcitatory inputsInhibitory interneuronsVoltage-sensitive dyeSynaptic inputsThalamocortical cellsCalcium transientsCalcium imagingNeurotransmitter release
2004
Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body
Bergsman JB, De Camilli P, McCormick DA. Multiple Large Inputs to Principal Cells in the Mouse Medial Nucleus of the Trapezoid Body. Journal Of Neurophysiology 2004, 92: 545-552. PMID: 15212444, DOI: 10.1152/jn.00927.2003.Peer-Reviewed Original ResearchConceptsPrincipal cellsTrapezoid bodyElectrophysiological criteriaMedial nucleusNerve terminalsMammalian auditory brain stemExcitatory postsynaptic current amplitudeCalyceal nerve terminalsMouse medial nucleusAuditory brain stemPostsynaptic current amplitudeStrong excitatory inputGiant nerve terminalCalyx of HeldPrincipal neuronsBrain stemExcitatory inputsSynaptic transmissionCentral synapseAnatomical studySynapseSound localizationTransmitter typeCellsCurrent amplitude
2001
Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons
Lüthi A, Di Paolo G, Cremona O, Daniell L, De Camilli P, McCormick D. Synaptojanin 1 Contributes to Maintaining the Stability of GABAergic Transmission in Primary Cultures of Cortical Neurons. Journal Of Neuroscience 2001, 21: 9101-9111. PMID: 11717343, PMCID: PMC6763888, DOI: 10.1523/jneurosci.21-23-09101.2001.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornCells, CulturedCerebral CortexElectric StimulationExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGABA AntagonistsGamma-Aminobutyric AcidMiceNerve Tissue ProteinsNeural InhibitionNeuronsPatch-Clamp TechniquesPhosphatidylinositolsPhosphoric Monoester HydrolasesSodium Channel BlockersSynapsesSynaptic TransmissionSynaptic VesiclesConceptsPaired-pulse depressionHalf-maximal depressionSteady-state depressionSynaptic depressionWhole-cell patch-clamp recordingsSlow depressionInhibitory synaptic responsesPaired-pulse protocolPrimary cortical culturesHigh-frequency stimulationPatch-clamp recordingsBi-exponential time courseUnitary IPSCsGABA releaseGABAergic transmissionCortical culturesPostsynaptic responsesCortical neuronsInhibitory synapsesSynaptic responsesSynaptojanin 1Presynaptic stimulationInhibitory neuronsRelease probabilityStimulation frequency
1999
Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling
Cremona O, Di Paolo G, Wenk M, Lüthi A, Kim W, Takei K, Daniell L, Nemoto Y, Shears S, Flavell R, McCormick D, De Camilli P. Essential Role of Phosphoinositide Metabolism in Synaptic Vesicle Recycling. Cell 1999, 99: 179-188. PMID: 10535736, DOI: 10.1016/s0092-8674(00)81649-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell-Free SystemCerebral CortexCoated Pits, Cell-MembraneEndocytosisEnzyme InhibitorsExonsHippocampusIn Vitro TechniquesMembrane PotentialsMiceMice, KnockoutMicroscopy, ElectronNerve EndingsNerve Tissue ProteinsNeuronsPhosphatidylinositolsPhosphoric Monoester HydrolasesSynaptic Vesicles