2024
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortex
2010
P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons
Yu Y, Maureira C, Liu X, McCormick D. P/Q and N Channels Control Baseline and Spike-Triggered Calcium Levels in Neocortical Axons and Synaptic Boutons. Journal Of Neuroscience 2010, 30: 11858-11869. PMID: 20810905, PMCID: PMC2947942, DOI: 10.1523/jneurosci.2651-10.2010.Peer-Reviewed Original ResearchConceptsAxon initial segmentNeuronal excitabilityPyramidal cellsCalcium concentrationPresynaptic terminalsWhole-cell patch-clamp recordingsPrefrontal cortical pyramidal cellsOmega-agatoxin IVAOmega-conotoxin GVIACortical pyramidal cellsPatch-clamp recordingsBaseline calcium concentrationAction potential repolarizationAction potential generationNeocortical axonsVoltage-activated ion channelsCalcium currentCortical axonsSynaptic terminalsCalcium levelsCalcium channelsSynaptic boutonsSuprathreshold depolarizationElectrophysiological propertiesSubthreshold depolarizationEndogenous Electric Fields May Guide Neocortical Network Activity
Fröhlich F, McCormick DA. Endogenous Electric Fields May Guide Neocortical Network Activity. Neuron 2010, 67: 129-143. PMID: 20624597, PMCID: PMC3139922, DOI: 10.1016/j.neuron.2010.06.005.Peer-Reviewed Original Research
2009
Rapid Neocortical Dynamics: Cellular and Network Mechanisms
Haider B, McCormick DA. Rapid Neocortical Dynamics: Cellular and Network Mechanisms. Neuron 2009, 62: 171-189. PMID: 19409263, PMCID: PMC3132648, DOI: 10.1016/j.neuron.2009.04.008.Peer-Reviewed Original Research
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barragesNeocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibition