2004
Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons
Lee K, Broberger C, Kim U, McCormick D. Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6716-6721. PMID: 15096604, PMCID: PMC404111, DOI: 10.1073/pnas.0400817101.Peer-Reviewed Original ResearchConceptsApplication of histamineGamma-aminobutyric acidPerigeniculate nucleusGABAergic neuronsSingle spike activityMammalian central nervous systemCentral nervous systemHistaminergic actionPerigeniculate neuronsHistaminergic fibersHistaminergic systemHistaminergic receptorsTuberomammillary nucleusIontophoretic applicationPostsynaptic factorsThalamocortical activityInhibitory responsesNeuronal activityThalamic oscillationsNervous systemHistamineMembrane hyperpolarizationSpindle wavesIonotropic receptorsReversal potential
2002
Inhibitory Interactions Between Ferret Thalamic Reticular Neurons
Shu Y, McCormick D. Inhibitory Interactions Between Ferret Thalamic Reticular Neurons. Journal Of Neurophysiology 2002, 87: 2571-2576. PMID: 11976393, DOI: 10.1152/jn.00850.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsNRT neuronsPostsynaptic potentialsThalamocortical activityReceptor-mediated inhibitory postsynaptic potentialsSpontaneous inhibitory postsynaptic potentialsImportant inhibitory inputThalamic excitatory inputsThalamic reticular nucleusInhibitory interactionsThalamic reticular neuronsThalamic relay nucleiAverage reversal potentialLocal inhibitory interactionsThalamocortical functionNRT cellsReceptor antagonistReticular neuronsReticular nucleusExcitatory inputsIntracellular recordingsInhibitory inputsRelay nucleiExtracellular recordingsNeurons
1999
Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulation
1997
SLEEP AND AROUSAL: Thalamocortical Mechanisms
McCormick D, Bal T. SLEEP AND AROUSAL: Thalamocortical Mechanisms. Annual Review Of Neuroscience 1997, 20: 185-215. PMID: 9056712, DOI: 10.1146/annurev.neuro.20.1.185.Peer-Reviewed Original ResearchConceptsThalamic reticular neuronsReticular neuronsCerebral cortex resultsCortical pyramidal cellsIntrinsic membrane propertiesBasal forebrainEnhanced excitabilityBrain stemMovement sleepAbsence seizuresTonic activityPyramidal cellsThalamocortical activitySleep rhythmsAnatomical interconnectionsCortex resultsThalamocortical mechanismsDifferent neurotransmittersParoxysmal eventsSpindle wavesRhythmic activitySpecific alterationsSleepSensory processingSlow waves
1994
Sensory gating mechanisms of the thalamus
McCormick D, Bal T. Sensory gating mechanisms of the thalamus. Current Opinion In Neurobiology 1994, 4: 550-556. PMID: 7812144, DOI: 10.1016/0959-4388(94)90056-6.Peer-Reviewed Original ResearchConceptsCerebral cortexThalamocortical circuitsRole of GABAASleep-wake cycleGABAB receptorsNeurotransmitter systemsThalamocortical activityAbnormal functionThalamusSensory-motor informationDense projectionsCortexAbnormal patternsCellular mechanismsVivo investigationsSensory informationGABAABrainstemReceptors
1992
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
McCormick D. Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Progress In Neurobiology 1992, 39: 337-388. PMID: 1354387, DOI: 10.1016/0301-0082(92)90012-4.Peer-Reviewed Original ResearchNeurotransmitter Actions in the Thalamus and Cerebral Cortex
McCormick D. Neurotransmitter Actions in the Thalamus and Cerebral Cortex. Journal Of Clinical Neurophysiology 1992, 9: 212-223. PMID: 1350591, DOI: 10.1097/00004691-199204010-00004.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral cortexThalamocortical activityInhibitory amino acidsSleep-wake cyclePostsynaptic actionsCortical neuronsNeurotransmitter actionEpileptic seizuresSynaptic informationTransmitter actionThalamusNorepinephrineAcetylcholineCortexNeurotransmittersSeizuresExcitabilityNeocortexHistamineExcitatoryState of activityNeuronsActivity