2024
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning
Martin K, Papadoyannis E, Schiavo J, Fadaei S, Issa H, Song S, Valencia S, Temiz N, McGinley M, McCormick D, Froemke R. Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning. Nature Neuroscience 2024, 1-15. PMID: 39284963, DOI: 10.1038/s41593-024-01767-4.Peer-Reviewed Original ResearchVagus nerve stimulationCentral cholinergic systemNerve stimulationEfficacy of vagus nerve stimulationCholinergic systemVagus nerve stimulation electrodesExperience-dependent plasticityAuditory cortical responsesPeripheral nerve stimulationCholinergic modulationAuditory discrimination taskClinical conditionsTwo-photon imagingCortical responsesCentral mechanismsCholinergic axonsStimulationEnhance task performanceNeural activityOptogenetic experimentsDiscrimination taskDiscrimination abilityEnhances perceptual learningPerceptual learningTask performanceDecision-making dynamics are predicted by arousal and uninstructed movements
Hulsey D, Zumwalt K, Mazzucato L, McCormick D, Jaramillo S. Decision-making dynamics are predicted by arousal and uninstructed movements. Cell Reports 2024, 43: 113709. PMID: 38280196, PMCID: PMC11016285, DOI: 10.1016/j.celrep.2024.113709.Peer-Reviewed Original ResearchUninstructed movementsStimulus-reward contingenciesTask-performance statesSensory discrimination taskSensory-guided behaviorOptimal performance statesTask performance dataDiscrimination taskTask performanceObservational measuresArousalBehavioral choicesDecision-making dynamicsMarkov modelOptimal performancePupil diameterPerformance stateSub-optimalTaskExternalitiesComputational modelPerformance
2019
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff D, Zagha E, McCarthy E, McCormick D. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex 2019, 30: 421-437. PMID: 31711133, PMCID: PMC7029483, DOI: 10.1093/cercor/bhz206.Peer-Reviewed Original ResearchConceptsVisual detection taskSecondary motor cortexTask performanceTask-related movementsCortical activityMotor cortexDetection taskTask-independent processesOptimal task performanceWidespread cortical activityTask-related changesHead-fixed miceResponse choicesDorsal cortexOrofacial movementsNeural activityTrial variationLick responsesArousal stateTrial variabilityTarget trialsLick rateCortexCortical signalsTrials
2015
Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection
McGinley MJ, David SV, McCormick DA. Cortical Membrane Potential Signature of Optimal States for Sensory Signal Detection. Neuron 2015, 87: 179-192. PMID: 26074005, PMCID: PMC4631312, DOI: 10.1016/j.neuron.2015.05.038.Peer-Reviewed Original ResearchConceptsCortical neuronsAuditory cortical neuronsSound-evoked responsesSensory-evoked responsesBackground synaptic activityMembrane potentialTonic periodsSignal detection behaviorSynaptic activityStable hyperpolarizationMembrane potential activitySlow oscillationsHippocampal recordingsNeural correlatesNeuronsTask performanceArousalPotential activityDetection behaviorPhysiological signaturesNoise detection taskArousal measuresMiceActivity