2014
Auditory cortex membrane potential dynamics in mice during challenging and ethologically relevant natural soundscapes
McGinley M, Castellucci G, McCormick D. Auditory cortex membrane potential dynamics in mice during challenging and ethologically relevant natural soundscapes. The Journal Of The Acoustical Society Of America 2014, 135: 2416-2416. DOI: 10.1121/1.4878018.Peer-Reviewed Original Research
2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2010
Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation
Haider B, Krause MR, Duque A, Yu Y, Touryan J, Mazer JA, McCormick DA. Synaptic and Network Mechanisms of Sparse and Reliable Visual Cortical Activity during Nonclassical Receptive Field Stimulation. Neuron 2010, 65: 107-121. PMID: 20152117, PMCID: PMC3110675, DOI: 10.1016/j.neuron.2009.12.005.Peer-Reviewed Original ResearchConceptsClassical receptive fieldCat primary visual cortexReceptive field stimulationVisual cortical activityPrimary visual cortexReceptive fieldsNonclassical receptive fieldPyramidal neuronsField stimulationSynaptic potentialsEntire visual fieldMembrane potential responsesNeuronal subtypesCortical activityVisual cortexRecurrent excitationVisual fieldVisual responsesIncreased activityStimulationInhibitory barragesNeuron spikingNetwork mechanismsVisual system studiesNatural vision
2006
Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings
Shu Y, Duque A, Yu Y, Haider B, McCormick D. Properties of Action-Potential Initiation in Neocortical Pyramidal Cells: Evidence From Whole Cell Axon Recordings. Journal Of Neurophysiology 2006, 97: 746-760. PMID: 17093120, DOI: 10.1152/jn.00922.2006.Peer-Reviewed Original ResearchConceptsCortical pyramidal cellsAction potential initiationAxon initial segmentPyramidal cellsAction potentialsSynaptic activityLayer 5 pyramidal neuronsSimultaneous whole-cell recordingsWhole-cell recordingsNeocortical pyramidal cellsRecurrent network activityAction potential generationInitial segmentIntradendritic injectionPyramidal neuronsApical dendritesEpileptiform activityCortical neuronsEpileptiform dischargesIntracortical axonsEpileptic seizuresSynaptic bombardmentCell recordingsDistal axonsSynaptic barrages
2001
ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES
McCormick D, Contreras D. ON THE CELLULAR AND NETWORK BASES OF EPILEPTIC SEIZURES. Annual Review Of Physiology 2001, 63: 815-846. PMID: 11181977, DOI: 10.1146/annurev.physiol.63.1.815.Peer-Reviewed Original ResearchConceptsCerebral cortexEpileptic seizuresSynchronized burstsRhythmic burst dischargesSpike-wave activityIntrinsic membrane propertiesForm of seizuresPeriod of hyperpolarizationLoss of balanceRecurrent excitatory connectionsEpileptic syndromesSeizure dischargesPyramidal neuronsTonic depolarizationEpileptiform activitySeizure generationBurst dischargesInhibitory neuronsInhibitory influenceInterictal spikesNormal brain rhythmsSynaptic plasticityAction potentialsSeizuresMammalian forebrain
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanismsIonic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spiking
1996
Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex
Gray C, McCormick D. Chattering Cells: Superficial Pyramidal Neurons Contributing to the Generation of Synchronous Oscillations in the Visual Cortex. Science 1996, 274: 109-113. PMID: 8810245, DOI: 10.1126/science.274.5284.109.Peer-Reviewed Original ResearchConceptsPyramidal neuronsVisual stimulationSuperficial pyramidal neuronsSubset of neuronsIntracellular recordingsSpontaneous activityGamma frequency bandRhythmic firingGamma-band activityVisual cortexCortical oscillationsNeuronsRepetitive burstsCortexIntracortical contributionsSuperficial layersStimulationMembrane potentialFunctional significanceCellsLarge populationSynchronous oscillationsResponse
1987
Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones.
McCormick D, Prince D. Post‐natal development of electrophysiological properties of rat cerebral cortical pyramidal neurones. The Journal Of Physiology 1987, 393: 743-762. PMID: 2895811, PMCID: PMC1192421, DOI: 10.1113/jphysiol.1987.sp016851.Peer-Reviewed Original ResearchConceptsCortical pyramidal neuronesPost-natal developmentImmature neuronesAction potentialsPyramidal neuronesCortical layer V pyramidal neuronsElectrophysiological propertiesRat sensorimotor cortical slicesLayer V pyramidal neuronsDependent action potentialsApparent input resistanceSensorimotor cortical slicesThird week postPyramidal neuronsCortical slicesIntracellular recordingsWeek postCortical neuronesNeuronesInput resistanceAdult neuronesLonger durationSpecific membrane resistanceInward rectificationAge
1985
Two types of muscarinic response to acetylcholine in mammalian cortical neurons.
McCormick D, Prince D. Two types of muscarinic response to acetylcholine in mammalian cortical neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 6344-6348. PMID: 3862134, PMCID: PMC391050, DOI: 10.1073/pnas.82.18.6344.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidInput resistanceMuscarinic responsesPyramidal neuronsPyramidal cellsInhibitory neurotransmitter gamma-aminobutyric acidNeurotransmitter gamma-aminobutyric acidShort-latency depolarizationsShort-latency inhibitionMammalian cortical neuronsNeuronal input resistanceSlow excitatory responsesApplication of acetylcholineVoltage-dependent depolarizationCholinergic inhibitionExcitatory responsesCholinergic receptorsVoltage-dependent increaseCortical slicesGABAergic interneuronsNicotinic antagonistsCholinergic agonistsCortical neuronsSlow depolarizationNeocortical neurons