1997
Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro
Lee K, McCormick D. Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro. Neuroscience 1997, 77: 335-350. PMID: 9472394, DOI: 10.1016/s0306-4522(96)00481-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationInhibitory postsynaptic potentialsThalamocortical neuronsLocal applicationTonic dischargeSpindle wavesPostsynaptic potentialsPerigeniculate nucleusGlutamate metabotropic receptor agonistMetabotropic receptor agonistMembrane depolarizationEffects of neurotransmittersSlow-wave sleepPerigeniculate neuronsLeak potassium currentGABAergic cellsGABAergic neuronsLateral geniculateReceptor agonistTonic activityWave sleepPotassium currentThalamic networkACPDNeurons
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance
1989
Convergence and divergence of neurotransmitter action in human cerebral cortex.
McCormick D, Williamson A. Convergence and divergence of neurotransmitter action in human cerebral cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 8098-8102. PMID: 2573061, PMCID: PMC298222, DOI: 10.1073/pnas.86.20.8098.Peer-Reviewed Original ResearchConceptsHuman cerebral cortexPostsynaptic actionsCerebral cortexPutative neurotransmittersMuscarinic receptor agonistApplication of acetylcholineCortical pyramidal cellsGamma-aminobutyric acidDistinct potassium currentsSpecific anatomical connectionsSpike frequency adaptationPostsynaptic receptorsReceptor agonistPyramidal cellsNeurotransmitter systemsM-currentNeuronal firingNeurotransmitter actionPotassium currentCortical activityAnatomical connectionsSerotoninNeurotransmittersNorepinephrineAcetylcholineCholinergic and noradrenergic modulation of thalamocortical processing
McCormick D. Cholinergic and noradrenergic modulation of thalamocortical processing. Trends In Neurosciences 1989, 12: 215-221. PMID: 2473557, DOI: 10.1016/0166-2236(89)90125-2.Peer-Reviewed Original ResearchConceptsThalamocortical processingPeriods of drowsinessState of excitabilityModulatory neurotransmitter systemsNeuronal responsivenessNoradrenergic componentThalamocortical rhythmsCortical neuronsNeurotransmitter systemsNoradrenergic modulationSynaptic inputsNeuronal activityPotassium currentSynchronized sleepMarked increaseRhythmic oscillationsRhythmNorepinephrineAcetylcholineExcitabilitySleepNeuronsDrowsiness