2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance