2024
Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning
Martin K, Papadoyannis E, Schiavo J, Fadaei S, Issa H, Song S, Valencia S, Temiz N, McGinley M, McCormick D, Froemke R. Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning. Nature Neuroscience 2024, 1-15. PMID: 39284963, DOI: 10.1038/s41593-024-01767-4.Peer-Reviewed Original ResearchVagus nerve stimulationCentral cholinergic systemNerve stimulationEfficacy of vagus nerve stimulationCholinergic systemVagus nerve stimulation electrodesExperience-dependent plasticityAuditory cortical responsesPeripheral nerve stimulationCholinergic modulationAuditory discrimination taskClinical conditionsTwo-photon imagingCortical responsesCentral mechanismsCholinergic axonsStimulationEnhance task performanceNeural activityOptogenetic experimentsDiscrimination taskDiscrimination abilityEnhances perceptual learningPerceptual learningTask performancePan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13: rp94167. PMID: 38808733, PMCID: PMC11136495, DOI: 10.7554/elife.94167.Peer-Reviewed Original ResearchConceptsTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsSensory discriminationMouse dorsalCortical areasBehavior primitivesMesoscopic imagingPopulations of neuronsNeural ensemblesLateral neocortexSimultaneous accessImage dataInternal stateNeuron resolutionNeocortexMiceActivation motifNeuronsSpontaneous changesArousalCortexPan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice
Vickers E, McCormick D. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice. ELife 2024, 13 DOI: 10.7554/elife.94167.3.Peer-Reviewed Original ResearchTask-specific cognitive demandsNeural activityFlow of neural activityTask-dependent behaviorsRegions of cortexCognitive demandsIn vivo preparationsSensory discriminationMouse dorsalCortical areasPopulations of neuronsBehavior primitivesNeural ensemblesLateral neocortexMesoscopic imagingSimultaneous accessInternal stateNeuron resolutionImage dataNeocortexMiceActivation motifNeuronsSpontaneous changesArousal
2020
Neuromodulation of Brain State and Behavior
McCormick D, Nestvogel D, He B. Neuromodulation of Brain State and Behavior. Annual Review Of Neuroscience 2020, 43: 1-25. PMID: 32250724, DOI: 10.1146/annurev-neuro-100219-105424.Peer-Reviewed Original Research
2019
Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task
Salkoff D, Zagha E, McCarthy E, McCormick D. Movement and Performance Explain Widespread Cortical Activity in a Visual Detection Task. Cerebral Cortex 2019, 30: 421-437. PMID: 31711133, PMCID: PMC7029483, DOI: 10.1093/cercor/bhz206.Peer-Reviewed Original ResearchConceptsVisual detection taskSecondary motor cortexTask performanceTask-related movementsCortical activityMotor cortexDetection taskTask-independent processesOptimal task performanceWidespread cortical activityTask-related changesHead-fixed miceResponse choicesDorsal cortexOrofacial movementsNeural activityTrial variationLick responsesArousal stateTrial variabilityTarget trialsLick rateCortexCortical signalsTrials
2015
Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha E, Ge X, McCormick DA. Competing Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output. Neuron 2015, 88: 565-577. PMID: 26593093, PMCID: PMC4660255, DOI: 10.1016/j.neuron.2015.09.044.Peer-Reviewed Original ResearchConceptsPopulations of neuronsAnticipation of movementMotor cortexCortical neuronsCortical circuitsIntracellular techniquesUnit recordingsNeural ensemblesMotor outputNeuronsSensory stimuliNeural activityMotor representationsSensory detection taskMotor commandsFuture studiesTask-related neural dynamicsCortexMiceCellular activities
1984
Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses
Clark G, McCormick D, Lavond D, Thompson R. Effects of lesions of cerebellar nuclei on conditioned behavioral and hippocampal neuronal responses. Brain Research 1984, 291: 125-136. PMID: 6697177, DOI: 10.1016/0006-8993(84)90658-9.Peer-Reviewed Original ResearchConceptsCerebellar nucleiNeuronal responsesUnilateral electrolytic lesionsHippocampal neuronal responsesEffects of lesionsIpsilateral sideContralateral sideControl animalsElectrolytic lesionsHippocampal responsesDeep nucleiLesionsLearning deficitsLeft sideRight sideNeural activityTrials of trainingComplete abolition
1981
The engram found? Role of the cerebellum in classical conditioning of nictitating membrane and eyelid responses
Mccormick D, Lavond D, Clark G, Kettner R, Rising C, Thompson R. The engram found? Role of the cerebellum in classical conditioning of nictitating membrane and eyelid responses. Psychonomic Bulletin & Review 1981, 18: 103-105. DOI: 10.3758/bf03333573.Peer-Reviewed Original ResearchIpsilateral cerebellumEye contralateralEyelid responsesReflex responsesStereotaxic lesionsNeural unit activityUnconditioned reflex responseNeuronal plasticityCerebellar lesionsElectrophysiological recordingsUnit activityCerebellumLesionsNeural activityClassical conditioningLarger ablationsTraining trialsBehavioral responses