2003
Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret
Monckton J, McCormick D. Comparative physiological and serotoninergic properties of pulvinar neurons in the monkey, cat and ferret. Thalamus & Related Systems 2003, 2: 239-252. DOI: 10.1016/s1472-9288(03)00022-0.Peer-Reviewed Original ResearchApplication of serotoninThalamocortical neuronsLow-threshold Ca2Pulvinar neuronsThreshold Ca2Hyperpolarization-activated cation currentSingle spike activityBasic electrophysiological propertiesDistinct firing modesProminent hyperpolarizationMembrane potassium conductanceSerotoninergic propertiesSignificant species-dependent differencesSpike activityCation currentMonkey neuronsElectrophysiological propertiesPotassium conductanceNeuronsPharmacological propertiesSerotoninMonkeysCatsPulvinarSpecies-dependent differences
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactionsFunctional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro
Kim U, Mccormick D. Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro. Journal Of Neurophysiology 1998, 80: 1222-1235. PMID: 9744934, DOI: 10.1152/jn.1998.80.3.1222.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthetics, LocalAnimalsApaminBicucullineCalciumCalcium Channel BlockersExcitatory Postsynaptic PotentialsFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesLidocaineMaleNeuronsOmega-Conotoxin GVIAPeptidesPeriodicityPotassiumPotassium ChannelsSodiumTetraethylammoniumTetrodotoxinConceptsApplication of apaminSlow afterhyperpolarizationLow-threshold Ca2Perigeniculate neuronsPlateau potentialsBlock of Ca2Spindle wave generationMedium-duration afterhyperpolarizationGABAergic neuronsTonic dischargeFast afterhyperpolarizationPerigeniculate nucleusIntracellular recordingsAfterhyperpolarizationAction potentialsRefractory periodLocal applicationProlonged depolarizationRepetitive Ca2Spindle wavesReversal potentialNeuronsApaminMembrane conductanceActivation
1997
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
Sanchez-Vives M, McCormick D. Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro. Journal Of Neuroscience 1997, 17: 8880-8893. PMID: 9348355, PMCID: PMC6573089, DOI: 10.1523/jneurosci.17-22-08880.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAnticonvulsantsBaclofenBicucullineCerebral CortexConvulsantsElectrophysiologyFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesMaleMembrane PotentialsNeural InhibitionNeural PathwaysNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticThalamic NucleiConceptsGABAB receptorsThalamocortical neuronsPGN neuronsGABAA receptorsThalamocortical cellsGABAB receptor-mediated IPSPsLocal applicationDorsal lateral geniculate nucleusReceptor-mediated IPSPsSynchronous slow oscillationsLow-intensity stimulationLow-threshold Ca2Lateral geniculate nucleusStrong activationPerigeniculate nucleusGeniculate nucleusIntracellular recordingsInhibitory influenceAction potentialsIntensity stimulationThreshold Ca2IPSPsNeuronsSpindle wavesPathological conditionsInhibitory Interactions between Perigeniculate GABAergic Neurons
Sanchez-Vives M, Bal T, McCormick D. Inhibitory Interactions between Perigeniculate GABAergic Neurons. Journal Of Neuroscience 1997, 17: 8894-8908. PMID: 9348356, PMCID: PMC6573073, DOI: 10.1523/jneurosci.17-22-08894.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAction PotentialsAnimalsAnticonvulsantsAxonsBaclofenBicucullineCalciumCerebral CortexExcitatory Postsynaptic PotentialsFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesGlutamic AcidMaleMuscimolNeural InhibitionNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticTetrodotoxinThalamic NucleiConceptsPGN neuronsPerigeniculate nucleusGABAB receptorsGABAergic neuronsIntracellular recordingsDorsal lateral geniculate nucleusActivation of inhibitionSpecific agonist muscimolGABAA receptor blockadeLow-threshold Ca2Lateral geniculate nucleusAverage reversal potentialBarrages of EPSPsFunctional GABAAPerigeniculate neuronsReceptor blockadeSlow IPSPBicuculline methiodideTonic dischargeAxon collateralsThalamocortical neuronsAgonist muscimolSubset of cellsGABAA receptorsGeniculate nucleusSynchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h
Bal T, McCormick D. Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h. Journal Of Neurophysiology 1997, 77: 3145-3156. PMID: 9212264, DOI: 10.1152/jn.1997.77.6.3145.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Inferior olive nucleusIO neuronsGuinea pigsHyperpolarization-activated cationic currentLocal applicationDependent action potentialsPresence of apaminMembrane potentialInferior olive neuronsIntracellular recordingsIntracellular injectionPacemaker potentialsRhythmic generationInferior oliveAfterhyperpolarizationAction potentialsCationic currentRemoval of inactivationExtracellular applicationNeuronsHyperpolarizationApaminCa2Pigs
1996
Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus?
Sanchez-Vives M, Bal T, Kim U, von Krosigk M, McCormick D. Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus? Journal Of Neuroscience 1996, 16: 5923-5941. PMID: 8815875, PMCID: PMC6579195, DOI: 10.1523/jneurosci.16-19-05923.1996.Peer-Reviewed Original ResearchConceptsInterlaminar zonesThalamocortical cellsDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret LGNdLow-threshold Ca2Calbindin-positive cellsLateral geniculate nucleusCalbindin stainingPerigeniculate neuronsPGN cellsContralateral eyeA-laminaeAxon collateralsC laminaePGN neuronsPerigeniculate nucleusGeniculate nucleusIntracellular injectionLamina AElectrophysiological propertiesLocal applicationProlonged depolarizationProlonged hyperpolarizationNeurons
1995
Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
McCormick D, Trent F, Ramoa A. Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei. Journal Of Neuroscience 1995, 15: 5739-5752. PMID: 7643215, PMCID: PMC6577643, DOI: 10.1523/jneurosci.15-08-05739.1995.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLow-threshold Ca2PGN neuronsIntracellular recordingsAction potentialsSpindle wavesPostnatal developmentGABAA receptorsRelay cellsElectrophysiological propertiesGABAA antagonist bicuculline methiodideHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusSpindle wave generationNetwork oscillationsDorsal lateral geniculateAction potential firingLateral geniculate nucleusThalamocortical relay cellsSynchronized network oscillationsBarrages of EPSPsLGNd relay cellsHigh-frequency burstsAcetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors
Lee K, McCormick D. Acetylcholine excites GABAergic neurons of the ferret perigeniculate nucleus through nicotinic receptors. Journal Of Neurophysiology 1995, 73: 2123-2128. PMID: 7623105, DOI: 10.1152/jn.1995.73.5.2123.Peer-Reviewed Original ResearchConceptsAction of acetylcholineSingle spike activityPerigeniculate nucleusPGN cellsGABAergic neuronsSpike activityLocal applicationDirect postsynaptic actionFerret thalamic slicesNicotinic antagonist hexamethoniumIntracellular recording techniquesAction potential firingLow-threshold Ca2Slow hyperpolarizing responseVitro. 2Antagonist hexamethoniumMembrane conductancePostsynaptic actionsGABAergic cellsMuscarinic antagonistMuscarinic receptorsDepolarizing responsePGN neuronsHyperpolarizing responseSynaptic transmissionRole of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro.
Bal T, von Krosigk M, McCormick D. Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. The Journal Of Physiology 1995, 483: 665-685. PMID: 7776250, PMCID: PMC1157809, DOI: 10.1113/jphysiol.1995.sp020613.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsPGN cellsSpindle wave generationLow-threshold Ca2Perigeniculate nucleusSpindle wavesPGN neuronsPostsynaptic potentialsRelay neuronsGABAA receptorsRelay cellsHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusNon-NMDA receptorsShort-duration inhibitory postsynaptic potentialMarked increaseLateral geniculate nucleusExtracellular recording techniquesVitro. 2GABAergic neuronsGABAergic receptorsGABAB receptorsProgressive hyperpolarizationSynaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide
1993
Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
Bal T, McCormick D. Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. The Journal Of Physiology 1993, 468: 669-691. PMID: 8254530, PMCID: PMC1143849, DOI: 10.1113/jphysiol.1993.sp019794.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Nucleus reticularis thalamiRhythmic burst firingThreshold Ca2Reticularis thalamiBurst firingExtracellular Ca2Action potentialsOscillatory activityShort-latency burstsSingle spike activityVitro. 2Fast action potentialsNon-selective cationSlow ADPThalamic afferentsTonic dischargeNRT cellsIntracellular recordingsIntracellular injectionSpike AHPsSpike activitySingle neuronesExtracellular applicationReversal potential
1992
A model of the electrophysiological properties of thalamocortical relay neurons
McCormick D, Huguenard J. A model of the electrophysiological properties of thalamocortical relay neurons. Journal Of Neurophysiology 1992, 68: 1384-1400. PMID: 1331356, DOI: 10.1152/jn.1992.68.4.1384.Peer-Reviewed Original Research
1990
Functional implications of burst firing and single spike activity in lateral geniculate relay neurons
McCormick D, Feeser H. Functional implications of burst firing and single spike activity in lateral geniculate relay neurons. Neuroscience 1990, 39: 103-113. PMID: 2089273, DOI: 10.1016/0306-4522(90)90225-s.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic potentialsAction potentialsSingle-spike modeThalamic neuronsPostsynaptic potentialsRelay neuronsRhythmic burstsExcitatory inputsLateral geniculate relay neuronsGeniculate relay neuronsPhasic excitatory inputPeripheral receptive fieldsSingle spike activityPeriods of drowsinessLow-threshold Ca2Slow-wave sleepThalamocortical relay neuronsIncoming excitatory inputsHigh-frequency burstsFiring modesNeuronal activityWave sleepSpike activityThreshold Ca2Neurons