1997
Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h
Bal T, McCormick D. Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h. Journal Of Neurophysiology 1997, 77: 3145-3156. PMID: 9212264, DOI: 10.1152/jn.1997.77.6.3145.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Inferior olive nucleusIO neuronsGuinea pigsHyperpolarization-activated cationic currentLocal applicationDependent action potentialsPresence of apaminMembrane potentialInferior olive neuronsIntracellular recordingsIntracellular injectionPacemaker potentialsRhythmic generationInferior oliveAfterhyperpolarizationAction potentialsCationic currentRemoval of inactivationExtracellular applicationNeuronsHyperpolarizationApaminCa2Pigs
1991
Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal
McCormick D, Williamson A. Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal. Journal Of Neuroscience 1991, 11: 3188-3199. PMID: 1658246, PMCID: PMC6575455, DOI: 10.1523/jneurosci.11-10-03188.1991.Peer-Reviewed Original ResearchConceptsSlow depolarizing responseApplication of histamineSingle spike activityDepolarizing responseSlow depolarizationIntracellular recordingsPotassium currentGuinea pigsLateral geniculate relay neuronsCat LGNdHyperpolarization-activated cation current IhEnhancement of IhGeniculate relay neuronsH2 antagonist cimetidineThalamic neuronal activityRhythmic burst dischargesH1-receptor antagonistAction of histamineH1 antagonist pyrilamineVoltage-clamp recordingsPossible cellular mechanismsApparent membrane conductanceHistaminergic controlHistaminergic projectionsMembrane conductance
1988
Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro
McCormick D, Prince D. Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro. Journal Of Neurophysiology 1988, 59: 978-996. PMID: 3367206, DOI: 10.1152/jn.1988.59.3.978.Peer-Reviewed Original ResearchConceptsSlow depolarizationElectrophysiological actionsPT neuronsGuinea pigsSlow membrane timeSpike frequency accommodationApplication of norepinephrineSingle spike activityMedial geniculate nucleusExtracellular potassium concentrationCat thalamic neuronsLarge afterhyperpolarizationSlow afterdepolarizationSlow afterhyperpolarizationAnteroventral nucleusCerebral cortexFrequency accommodationThalamic neuronsThalamocortical rhythmsThalamic nucleiGeniculate nucleusIntracellular recordingsNoradrenergic modulationSynaptic transmissionThalamic slices
1985
Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick D, Connors B, Lighthall J, Prince D. Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. Journal Of Neurophysiology 1985, 54: 782-806. PMID: 2999347, DOI: 10.1152/jn.1985.54.4.782.Peer-Reviewed Original ResearchConceptsRegular-spiking cellsAction potentialsSpiny stellate neuronsIntracellular recording techniquesAnterior cingulate areaDistinct neuronal classesAnterior cingulate cortexProminent afterhyperpolarizationTonic currentsStellate neuronsMean durationTrain of spikesCingulate areasFluorescent dye Lucifer Yellow CHDye Lucifer Yellow CHSynaptic pathwaysIntracellular injectionSpike frequencyCingulate cortexFast spikingSpike riseElectrophysiological propertiesNeuronal classesGuinea pigsComparative electrophysiology